Alnylam Pharmaceuticals
Associate Scientist II, Conjugation Chemistry
Alnylam Pharmaceuticals, Cambridge, Massachusetts, us, 02140
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Associate Scientist II, Conjugation Chemistry
role at
Alnylam Pharmaceuticals
We are seeking an associate scientist-II to join our protein sciences team to contribute to our protein production and conjugation efforts. The candidate must be independent, goal oriented, technically competent, and able to efficiently work across multiple projects. We are searching for enthusiastic, innovative, and highly motivated individuals, with scientific background in protein expression, purification, protein conjugation and analytical techniques, who are comfortable working in a fast‑paced entrepreneurial environment. The successful candidate will be part of cross‑functional teams including biologists, chemists, and pharmacologists and will contribute to advancing research programs across multiple therapeutic modalities.
This lab‑based position is onsite and will be located at 675 W. Kendall St. Cambridge, MA 02142.
Responsibilities
Work closely with the protein sciences team to deliver and validate proteins and protein conjugates at various production scales.
Design, plan, and perform protein conjugation experiments to support in vitro and in vivo evaluations, contributing to project‑related scientific activities with some guidance from team members.
Utilize UV–Vis spectroscopy and HPLC to analyze, purify, quantify, characterize, and formulate protein conjugates.
Contribute to the maintenance of laboratory infrastructure and equipment.
Support group organization, productivity, and expertise through collaboration and idea exchange.
Meet quality, quantity, and timeline expectations for all assigned projects.
Support discovery efforts in protein sciences.
Maintain accurate and complete electronic notebook records.
Communicate experimental plans and data to multiple cross‑functional scientific teams.
Qualifications
BS/MS degree in Chemistry, biochemistry, or a related field, with 0–1 years of relevant laboratory experience in a biopharma or academic setting.
Experience with modern bioconjugation chemistry and analytical techniques.
Experience with instrumentation such as Agilent and ÄKTA HPLC systems, TFF, and UV–Vis spectrometry.
Experience with protein and protein conjugate analysis (e.g., affinity chromatography, SEC, RP‑HPLC, HIC, IEX, SDS‑PAGE, UV–Vis spectroscopy) and label‑free binding techniques (SPR and/or BLI) preferred.
Experience developing new chromatographic methods is a plus.
Knowledge of protein purification using ÄKTA systems preferred.
About Alnylam We are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize‑winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late‑stage programs, and bold vision reflect our core values:
fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people . We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another.
At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E‑Verify Employer.
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Associate Scientist II, Conjugation Chemistry
role at
Alnylam Pharmaceuticals
We are seeking an associate scientist-II to join our protein sciences team to contribute to our protein production and conjugation efforts. The candidate must be independent, goal oriented, technically competent, and able to efficiently work across multiple projects. We are searching for enthusiastic, innovative, and highly motivated individuals, with scientific background in protein expression, purification, protein conjugation and analytical techniques, who are comfortable working in a fast‑paced entrepreneurial environment. The successful candidate will be part of cross‑functional teams including biologists, chemists, and pharmacologists and will contribute to advancing research programs across multiple therapeutic modalities.
This lab‑based position is onsite and will be located at 675 W. Kendall St. Cambridge, MA 02142.
Responsibilities
Work closely with the protein sciences team to deliver and validate proteins and protein conjugates at various production scales.
Design, plan, and perform protein conjugation experiments to support in vitro and in vivo evaluations, contributing to project‑related scientific activities with some guidance from team members.
Utilize UV–Vis spectroscopy and HPLC to analyze, purify, quantify, characterize, and formulate protein conjugates.
Contribute to the maintenance of laboratory infrastructure and equipment.
Support group organization, productivity, and expertise through collaboration and idea exchange.
Meet quality, quantity, and timeline expectations for all assigned projects.
Support discovery efforts in protein sciences.
Maintain accurate and complete electronic notebook records.
Communicate experimental plans and data to multiple cross‑functional scientific teams.
Qualifications
BS/MS degree in Chemistry, biochemistry, or a related field, with 0–1 years of relevant laboratory experience in a biopharma or academic setting.
Experience with modern bioconjugation chemistry and analytical techniques.
Experience with instrumentation such as Agilent and ÄKTA HPLC systems, TFF, and UV–Vis spectrometry.
Experience with protein and protein conjugate analysis (e.g., affinity chromatography, SEC, RP‑HPLC, HIC, IEX, SDS‑PAGE, UV–Vis spectroscopy) and label‑free binding techniques (SPR and/or BLI) preferred.
Experience developing new chromatographic methods is a plus.
Knowledge of protein purification using ÄKTA systems preferred.
About Alnylam We are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize‑winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late‑stage programs, and bold vision reflect our core values:
fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people . We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another.
At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E‑Verify Employer.
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