Mindlance
Job Overview
The Quantitative, Translational ADME Sciences (QTAS) department at *** is seeking a highly motivated scientist to join the Biologics bioanalysis, characterization, and proteomics group. The main function of this position is to develop and implement LC/MS-based bioanalysis and in vitro characterization assays for Client biologics entities.
The successful candidate will develop, optimize, and implement Client and routine LC/MS-based bioanalytical methods to support in vivo PK, TK and PK/PD studies as well as in vitro stability characterization of therapeutic proteins, peptides, and oligonucleotides. Responsibilities include sample preparation, method development, bioanalytical assay operations, data analysis, report generation, and data presentation.
Key Responsibilities
Operate and maintain LC/MS instruments to generate high-quality experimental data.
Perform affinity purification of therapeutic proteins (including monoclonal and bispecific antibodies, antibody drug conjugates, antibody-siRNA conjugates, and fusion proteins) from biological matrices.
Analyze data and maintain detailed, accurate and comprehensive study documentation in electronic laboratory notebooks.
Facilitate assay optimization and implementation to ensure laboratory capacity and data quality.
Communicate data interpretation internally and externally.
Qualifications
BS or MS in chemistry, pharmacology or related fields with 3+ years (BS) or 2+ years (MS) in a pharmaceutical industry setting focusing on mass spectrometry.
Hands‑on experience with QQQ (SCIEX), qTOF (Agilent, Bruker, SCIEX) and/or Orbitrap (Thermo) mass spectrometers.
Hands‑on experience with automated liquid handling systems.
Hands‑on experience with oligonucleotide analysis.
Prior industry experience in drug discovery/development with in-depth understanding of PK, TK and PK/PD studies and corresponding bioanalytical assays.
Highly motivated, self‑driven and results‑oriented with excellent communication and presentation skills; capable of working both as a team player and individual contributor.
EEO Statement Mindlance is an Equal Opportunity Employer and does not discriminate in employment on the basis of Minority/Gender/Disability/Religion/LGBTQI/Age/Veterans.
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The successful candidate will develop, optimize, and implement Client and routine LC/MS-based bioanalytical methods to support in vivo PK, TK and PK/PD studies as well as in vitro stability characterization of therapeutic proteins, peptides, and oligonucleotides. Responsibilities include sample preparation, method development, bioanalytical assay operations, data analysis, report generation, and data presentation.
Key Responsibilities
Operate and maintain LC/MS instruments to generate high-quality experimental data.
Perform affinity purification of therapeutic proteins (including monoclonal and bispecific antibodies, antibody drug conjugates, antibody-siRNA conjugates, and fusion proteins) from biological matrices.
Analyze data and maintain detailed, accurate and comprehensive study documentation in electronic laboratory notebooks.
Facilitate assay optimization and implementation to ensure laboratory capacity and data quality.
Communicate data interpretation internally and externally.
Qualifications
BS or MS in chemistry, pharmacology or related fields with 3+ years (BS) or 2+ years (MS) in a pharmaceutical industry setting focusing on mass spectrometry.
Hands‑on experience with QQQ (SCIEX), qTOF (Agilent, Bruker, SCIEX) and/or Orbitrap (Thermo) mass spectrometers.
Hands‑on experience with automated liquid handling systems.
Hands‑on experience with oligonucleotide analysis.
Prior industry experience in drug discovery/development with in-depth understanding of PK, TK and PK/PD studies and corresponding bioanalytical assays.
Highly motivated, self‑driven and results‑oriented with excellent communication and presentation skills; capable of working both as a team player and individual contributor.
EEO Statement Mindlance is an Equal Opportunity Employer and does not discriminate in employment on the basis of Minority/Gender/Disability/Religion/LGBTQI/Age/Veterans.
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