Z-Alpha Therapeutics
In Vivio Biologist, Radiopharmaceutical Sr. Scientist - Director DURHAM, NC
Z-Alpha Therapeutics, Boston, Massachusetts, us, 02298
In Vivio Biologist, Radiopharmaceutical Sr. Scientist - Director DURHAM, NC
** POSITION REQUIRES COMPANY SPONSORED RELOCATION TO DURHAM, NC **
Z-Alpha Therapeutics is a pharmaceutical company dedicated to the discovery and development of radiotherapeutics targeting key biological pathways for solid tumors. The company has a revolutionary technology platform in the next generation of alpha particle therapy with potential to be a more targeted therapy, increasing efficacy and limiting toxicity compared to competitors in the radiotherapeutics space. The company has a world‑class team of scientists with decades of experience and foundational intellectual property that enables the potential to bring multiple drug candidates into the clinic.
Job Purpose Provide senior‑level scientific, operational, and strategic leadership in radiopharmaceutical oncology drug development. Lead the design and execution of preclinical in vivo studies, radiochemistry applications, and translational strategies that support candidate nomination and early clinical development. The position is located in Durham, NC area and is full‑time on site.
Key Responsibilities
Set up and manage / support activities in a Radiopharma vivarium.
Design and execute biodistribution, dosimetry, PK/PD, tolerability, and efficacy studies in rodent xenograft models.
Analyze tissues, plasma, and blood samples using gamma counting, blood analyzers, and in vitro assays.
Oversee radiolabeling studies with therapeutic and imaging isotopes (e.g., ^225Ac, ^177Lu, ^211At) and ensure high‑quality imaging and data interpretation (SPECT, PET, multimodal imaging).
Prepare high‑quality protocols, data packages, and reports that support IND‑enabling studies, Investigator’s Brochures, and regulatory submissions.
Contribute to the development of preclinical models for radioligand therapy in oncology models.
Manage CRO collaborations, including study design, execution, scheduling, and data/report review.
Lead and mentor a cross‑functional team of scientists and technicians; provide training in rodent handling, surgical techniques, formulation prep, dosing (IV, PO, IP, SQ), and tissue collection.
Establish and maintain SOPs for all in‑vivo and radiopharmaceutical procedures; ensure strict compliance with IACUC, radiation safety, and biohazard regulations.
Collaborate closely with radiochemistry, biology, and clinical teams to align in‑vivo and imaging strategies with program objectives.
Represent the organization at external meetings, author scientific publications, and contribute to the company’s reputation in radiopharmaceutical oncology.
Qualifications
Education:
MS or PhD in Radiochemistry, Pharmacology, Cancer Biology, Molecular Biology, or related field. Equivalent advanced training and experience may be considered.
Experience:
6–10 years of relevant experience in preclinical oncology drug development, with at least 2–3 years of management responsibility.
Regulatory:
Experience contributing to IND/IB filings and regulatory documentation.
Strong project management skills; ability to manage internal/external resources, budgets, and timelines.
What We Offer
Opportunity to lead cutting‑edge radiopharmaceutical oncology programs from discovery through IND.
Hands‑on science combined with strategic leadership and client engagement.
A collaborative, multidisciplinary environment with room for growth into higher leadership roles.
** POSITION REQUIRES COMPANY SPONSORED RELOCATION TO DURHAM, NC **
** PLEASE RESPOND TO THIS POSTING IF INTERESTED - DO NOT CONTACT EMPLOYEES **
#J-18808-Ljbffr
Z-Alpha Therapeutics is a pharmaceutical company dedicated to the discovery and development of radiotherapeutics targeting key biological pathways for solid tumors. The company has a revolutionary technology platform in the next generation of alpha particle therapy with potential to be a more targeted therapy, increasing efficacy and limiting toxicity compared to competitors in the radiotherapeutics space. The company has a world‑class team of scientists with decades of experience and foundational intellectual property that enables the potential to bring multiple drug candidates into the clinic.
Job Purpose Provide senior‑level scientific, operational, and strategic leadership in radiopharmaceutical oncology drug development. Lead the design and execution of preclinical in vivo studies, radiochemistry applications, and translational strategies that support candidate nomination and early clinical development. The position is located in Durham, NC area and is full‑time on site.
Key Responsibilities
Set up and manage / support activities in a Radiopharma vivarium.
Design and execute biodistribution, dosimetry, PK/PD, tolerability, and efficacy studies in rodent xenograft models.
Analyze tissues, plasma, and blood samples using gamma counting, blood analyzers, and in vitro assays.
Oversee radiolabeling studies with therapeutic and imaging isotopes (e.g., ^225Ac, ^177Lu, ^211At) and ensure high‑quality imaging and data interpretation (SPECT, PET, multimodal imaging).
Prepare high‑quality protocols, data packages, and reports that support IND‑enabling studies, Investigator’s Brochures, and regulatory submissions.
Contribute to the development of preclinical models for radioligand therapy in oncology models.
Manage CRO collaborations, including study design, execution, scheduling, and data/report review.
Lead and mentor a cross‑functional team of scientists and technicians; provide training in rodent handling, surgical techniques, formulation prep, dosing (IV, PO, IP, SQ), and tissue collection.
Establish and maintain SOPs for all in‑vivo and radiopharmaceutical procedures; ensure strict compliance with IACUC, radiation safety, and biohazard regulations.
Collaborate closely with radiochemistry, biology, and clinical teams to align in‑vivo and imaging strategies with program objectives.
Represent the organization at external meetings, author scientific publications, and contribute to the company’s reputation in radiopharmaceutical oncology.
Qualifications
Education:
MS or PhD in Radiochemistry, Pharmacology, Cancer Biology, Molecular Biology, or related field. Equivalent advanced training and experience may be considered.
Experience:
6–10 years of relevant experience in preclinical oncology drug development, with at least 2–3 years of management responsibility.
Regulatory:
Experience contributing to IND/IB filings and regulatory documentation.
Strong project management skills; ability to manage internal/external resources, budgets, and timelines.
What We Offer
Opportunity to lead cutting‑edge radiopharmaceutical oncology programs from discovery through IND.
Hands‑on science combined with strategic leadership and client engagement.
A collaborative, multidisciplinary environment with room for growth into higher leadership roles.
** POSITION REQUIRES COMPANY SPONSORED RELOCATION TO DURHAM, NC **
** PLEASE RESPOND TO THIS POSTING IF INTERESTED - DO NOT CONTACT EMPLOYEES **
#J-18808-Ljbffr