Pfizer, S.A. de C.V
Scientist--ADC Biology (Non-PhD)
Pfizer, S.A. de C.V, Bothell, Washington, United States, 98021
Overview
As a Scientist on our Antibody-Drug Conjugate (ADC) Biology team, you will play a pivotal role in driving the development of next-generation ADCs for cancer therapy. Through collaborative, cross-functional research spanning early discovery to clinical development, you will help shape innovative therapeutic strategies that address unmet medical needs. This role involves designing and implementing robust biological assays and screening strategies to evaluate novel payload chemotypes, identifying cancer indications most susceptible to these payloads, and optimizing their pairing with tumor-associated antigens to enhance therapeutic efficacy. You will analyze, interpret, and clearly communicate experimental data to multidisciplinary teams and key stakeholders, and you may contribute to IND- and BLA-enabling data packages supporting regulatory submissions and clinical advancement. This position offers the opportunity to work at the forefront of ADC innovation, contributing to a dynamic pipeline and translating cutting-edge science into transformative cancer treatments. Key Responsibilities
Apply cellular, proteomic, and molecular biology laboratory techniques to preclinical research projects in the area of cancer biology Execute molecular and cell-based methodologies including flow cytometry, immunohistochemistry, cytotoxicity assays, reporter assays, ELISA, alpha-LISA, western blotting, WES and in vitro PD assays Investigate novel ADC targets, linker payloads, and new MOAs through development, optimization, and execution of complex assays Independently design, execute, analyze and document key experiments to enable clear go/no-go decisions; present findings to large and small audiences Provide leadership within the technical area of expertise; may train others Maintain rigorous records of experimental progress using electronic laboratory notebooks Minimum Requirements
Bachelor's Degree in Biology, Biochemistry, Engineering, Immunology or a related field and 6+ years of relevant industry ADC Biology or small molecule experience OR Master's degree in Biology, Biochemistry, Engineering, Immunology or a related field and 4+ years of relevant industry ADC Biology or small molecule experience Experience with tissue culture and diverse molecular biology techniques Experience with protein quantification methods, e.g., WES, western blotting Proficiency in flow cytometry analysis Experience working in and adapting to a rapidly evolving environment Experience working independently and as part of a team Strong written and verbal communication skills with ability to communicate to a wide range of audiences Excellent organizational and planning skills Preferred Requirements
Knowledge of therapeutic antibodies, protein degraders, and/or ADCs Knowledge of epigenetics, signal transduction, and/or metastasis pathways Experience with cell-based assay development for screening purposes Experience with immunohistochemistry, immunofluorescence, and/or imaging Experience with utilization and analysis of data from 'omics platforms Proficiency with software for data analysis Physical/Environmental Requirements
Lifting, sitting, standing, walking, bending, ability to perform mathematical calculations and complex data analysis Non-Standard Work Schedule, Travel or Environment
Occasional non-standard hours; occasional travel (1-2 times per year). Must adhere to safe work practices and procedures. Position Details
Location: On Premise Relocation assistance may be available based on business needs and eligibility. Equal Opportunity and Accessibility
Pfizer is an equal opportunity employer. Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable laws governing nondiscrimination and employment eligibility verification. If you require accessibility accommodations during the application process, please contact us.
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As a Scientist on our Antibody-Drug Conjugate (ADC) Biology team, you will play a pivotal role in driving the development of next-generation ADCs for cancer therapy. Through collaborative, cross-functional research spanning early discovery to clinical development, you will help shape innovative therapeutic strategies that address unmet medical needs. This role involves designing and implementing robust biological assays and screening strategies to evaluate novel payload chemotypes, identifying cancer indications most susceptible to these payloads, and optimizing their pairing with tumor-associated antigens to enhance therapeutic efficacy. You will analyze, interpret, and clearly communicate experimental data to multidisciplinary teams and key stakeholders, and you may contribute to IND- and BLA-enabling data packages supporting regulatory submissions and clinical advancement. This position offers the opportunity to work at the forefront of ADC innovation, contributing to a dynamic pipeline and translating cutting-edge science into transformative cancer treatments. Key Responsibilities
Apply cellular, proteomic, and molecular biology laboratory techniques to preclinical research projects in the area of cancer biology Execute molecular and cell-based methodologies including flow cytometry, immunohistochemistry, cytotoxicity assays, reporter assays, ELISA, alpha-LISA, western blotting, WES and in vitro PD assays Investigate novel ADC targets, linker payloads, and new MOAs through development, optimization, and execution of complex assays Independently design, execute, analyze and document key experiments to enable clear go/no-go decisions; present findings to large and small audiences Provide leadership within the technical area of expertise; may train others Maintain rigorous records of experimental progress using electronic laboratory notebooks Minimum Requirements
Bachelor's Degree in Biology, Biochemistry, Engineering, Immunology or a related field and 6+ years of relevant industry ADC Biology or small molecule experience OR Master's degree in Biology, Biochemistry, Engineering, Immunology or a related field and 4+ years of relevant industry ADC Biology or small molecule experience Experience with tissue culture and diverse molecular biology techniques Experience with protein quantification methods, e.g., WES, western blotting Proficiency in flow cytometry analysis Experience working in and adapting to a rapidly evolving environment Experience working independently and as part of a team Strong written and verbal communication skills with ability to communicate to a wide range of audiences Excellent organizational and planning skills Preferred Requirements
Knowledge of therapeutic antibodies, protein degraders, and/or ADCs Knowledge of epigenetics, signal transduction, and/or metastasis pathways Experience with cell-based assay development for screening purposes Experience with immunohistochemistry, immunofluorescence, and/or imaging Experience with utilization and analysis of data from 'omics platforms Proficiency with software for data analysis Physical/Environmental Requirements
Lifting, sitting, standing, walking, bending, ability to perform mathematical calculations and complex data analysis Non-Standard Work Schedule, Travel or Environment
Occasional non-standard hours; occasional travel (1-2 times per year). Must adhere to safe work practices and procedures. Position Details
Location: On Premise Relocation assistance may be available based on business needs and eligibility. Equal Opportunity and Accessibility
Pfizer is an equal opportunity employer. Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable laws governing nondiscrimination and employment eligibility verification. If you require accessibility accommodations during the application process, please contact us.
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