GSK
In Vivo Respiratory Principal Scientist
GSK, Collegeville, Pennsylvania, United States, 19426
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In Vivo Respiratory Principal Scientist
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GSK As a lab-based In Vivo Respiratory Principal Scientist in the Complex Models group within the Respiratory, Immunology & Inflammation Biology Unit (RIIBU), you will contribute to the in vivo biology strategy and will lead the design, execution, and reporting of preclinical integrative (in vivo, in vitro and ex vivo) experiments to support therapeutic area teams and drug discovery projects from target validation through to clinical phases. You will have the opportunity to work on targets, in vivo models, and integrative, translational biology relevant to respiratory diseases such as COPD and IPF/ILD. Responsibilities
Contribute to the design and lab/vivarium-based execution of in vivo strategies for the respiratory disease area. Contribute to the delivery of Respiratory preclinical efficacy and mechanistic in vivo studies using respiratory models to enable PK/PD and translational biomarker data generation. Lead discussions to ascertain a robust understanding of scientific rationale, key objectives, endpoints and Go/No-Go decisions for in vivo models and studies, setting clear goals and timelines. Use understanding of PK/PD principles relating to respiratory diseases to drive innovation and independently design, execute, analyze, and present in vivo studies as the In Vivo Leader (IVL) representative on portfolio projects with input from Biology Leader (BL), Project Leader (PL), and Complex Models Leadership Team. Understand and independently apply robust study design (RSD) principles, gain input from Subject Matter Experts and matrix partners prior to seeking endorsement/recommendations for animal studies at ISR forum and PSB. Anticipate potential challenges with experiments and independently resolve technical issues in experimental planning, setup and execution with minimal guidance. Lab/vivarium-based execution to enable sample/tissue acquisition, processing, and analysis to enable integration of PK/PD and translational biomarker data from in vivo studies and where necessary utilize advanced ex vivo assay techniques such as Flow cytometry, ELISA’s, MSD, Luminex and qPCR. Serve as key contact for animal studies, including provision of out of hours procedures as required. Maintain technical expertise/competency in animal handling, dosing, blood and tissue collection, and measurements of biological/physiological function (e.g. lung function, hemodynamics). Be familiar with Federal Laws surrounding animal use in research and the local governance process (IACUC, AUP). Be familiar with severity limits/constraints related to adverse effects and respond as required under IACUC, AUP and GSK Policy on Care, Welfare and Treatment of Animals. Assess animal health and welfare, document findings, and act on them or seek expert advice when necessary. Work effectively with internal matrix partners (e.g. BL, PL, RTech) and lead external animal studies placed externally (e.g. CRO, academic groups) including Study Monitoring responsibilities. Maintain accurate, up to date electronic laboratory records in alignment with data integrity standards and ensure compliance with all relevant SOPs, Risk Assessments and safety guidelines. Foster an enterprise culture of innovation, collaboration, inclusion, and continuous learning. Keep up to date with relevant literature and apply insights to in vivo strategies and studies. Basic Qualifications, Knowledge, Skills, and Experience Required
BSc in a biological science with 5+ years of respiratory in vivo experience, or MSc with 4+ years, or PhD with 2+ years, in industry or academia. Knowledge of respiratory disease mechanisms in COPD and IPF/ILD and use of in vivo systems to interrogate pathophysiological mechanisms. Hands-on experience with animal model systems in the respiratory disease area, including lung function measurement (e.g., Whole-Body Plethysmography, Dynamic Compliance and resistance, FEV and FVC). Experience with in vivo models in the respiratory disease area including animal handling, dosing (intranasal and intratracheal), tissue necropsy (BAL and lung dissection), and blood sampling. Experience with Flow cytometry (processing of respiratory-relevant tissues), ELISAs, MSD, Luminex and qPCR or RNAseq. Experience overseeing external animal studies conducted at CROs or academic groups as study monitor. Experience with writing and critiquing scientific documents and communicating scientific ideas to line and matrix teams. Preferred Requirements
Expertise in biomarker assay development in the respiratory disease area to define PKPD parameters and inform translational research. Experience in drug discovery processes within the pharmaceutical or biotech industry and knowledge of the drug discovery pillars. Familiarity with omics platforms (spatial, bulk and single cell RNA seq) and advanced imaging technologies. Proven ability to balance multiple priorities and meet deadlines. Knowledge of regulatory guidelines relating to the use of animals in research and compliance requirements. Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees. Why GSK? Uniting science, technology and talent to get ahead of disease together. GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people. If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US). GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information, military service or any basis prohibited under federal, state or local law. Important notice to Employment businesses/ Agencies. GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement between the agency and GSK. In the absence of such written authorization, actions undertaken by the employment business/agency shall be deemed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or referrals. Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses incurred on your behalf in the event you are afforded an interview. This capture of applicable transfers of value is necessary to ensure GSK’s compliance with federal and state US transparency requirements. For more information, please visit the CMS Open Payments data site.
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In Vivo Respiratory Principal Scientist
role at
GSK As a lab-based In Vivo Respiratory Principal Scientist in the Complex Models group within the Respiratory, Immunology & Inflammation Biology Unit (RIIBU), you will contribute to the in vivo biology strategy and will lead the design, execution, and reporting of preclinical integrative (in vivo, in vitro and ex vivo) experiments to support therapeutic area teams and drug discovery projects from target validation through to clinical phases. You will have the opportunity to work on targets, in vivo models, and integrative, translational biology relevant to respiratory diseases such as COPD and IPF/ILD. Responsibilities
Contribute to the design and lab/vivarium-based execution of in vivo strategies for the respiratory disease area. Contribute to the delivery of Respiratory preclinical efficacy and mechanistic in vivo studies using respiratory models to enable PK/PD and translational biomarker data generation. Lead discussions to ascertain a robust understanding of scientific rationale, key objectives, endpoints and Go/No-Go decisions for in vivo models and studies, setting clear goals and timelines. Use understanding of PK/PD principles relating to respiratory diseases to drive innovation and independently design, execute, analyze, and present in vivo studies as the In Vivo Leader (IVL) representative on portfolio projects with input from Biology Leader (BL), Project Leader (PL), and Complex Models Leadership Team. Understand and independently apply robust study design (RSD) principles, gain input from Subject Matter Experts and matrix partners prior to seeking endorsement/recommendations for animal studies at ISR forum and PSB. Anticipate potential challenges with experiments and independently resolve technical issues in experimental planning, setup and execution with minimal guidance. Lab/vivarium-based execution to enable sample/tissue acquisition, processing, and analysis to enable integration of PK/PD and translational biomarker data from in vivo studies and where necessary utilize advanced ex vivo assay techniques such as Flow cytometry, ELISA’s, MSD, Luminex and qPCR. Serve as key contact for animal studies, including provision of out of hours procedures as required. Maintain technical expertise/competency in animal handling, dosing, blood and tissue collection, and measurements of biological/physiological function (e.g. lung function, hemodynamics). Be familiar with Federal Laws surrounding animal use in research and the local governance process (IACUC, AUP). Be familiar with severity limits/constraints related to adverse effects and respond as required under IACUC, AUP and GSK Policy on Care, Welfare and Treatment of Animals. Assess animal health and welfare, document findings, and act on them or seek expert advice when necessary. Work effectively with internal matrix partners (e.g. BL, PL, RTech) and lead external animal studies placed externally (e.g. CRO, academic groups) including Study Monitoring responsibilities. Maintain accurate, up to date electronic laboratory records in alignment with data integrity standards and ensure compliance with all relevant SOPs, Risk Assessments and safety guidelines. Foster an enterprise culture of innovation, collaboration, inclusion, and continuous learning. Keep up to date with relevant literature and apply insights to in vivo strategies and studies. Basic Qualifications, Knowledge, Skills, and Experience Required
BSc in a biological science with 5+ years of respiratory in vivo experience, or MSc with 4+ years, or PhD with 2+ years, in industry or academia. Knowledge of respiratory disease mechanisms in COPD and IPF/ILD and use of in vivo systems to interrogate pathophysiological mechanisms. Hands-on experience with animal model systems in the respiratory disease area, including lung function measurement (e.g., Whole-Body Plethysmography, Dynamic Compliance and resistance, FEV and FVC). Experience with in vivo models in the respiratory disease area including animal handling, dosing (intranasal and intratracheal), tissue necropsy (BAL and lung dissection), and blood sampling. Experience with Flow cytometry (processing of respiratory-relevant tissues), ELISAs, MSD, Luminex and qPCR or RNAseq. Experience overseeing external animal studies conducted at CROs or academic groups as study monitor. Experience with writing and critiquing scientific documents and communicating scientific ideas to line and matrix teams. Preferred Requirements
Expertise in biomarker assay development in the respiratory disease area to define PKPD parameters and inform translational research. Experience in drug discovery processes within the pharmaceutical or biotech industry and knowledge of the drug discovery pillars. Familiarity with omics platforms (spatial, bulk and single cell RNA seq) and advanced imaging technologies. Proven ability to balance multiple priorities and meet deadlines. Knowledge of regulatory guidelines relating to the use of animals in research and compliance requirements. Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees. Why GSK? Uniting science, technology and talent to get ahead of disease together. GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people. If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US). GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information, military service or any basis prohibited under federal, state or local law. Important notice to Employment businesses/ Agencies. GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement between the agency and GSK. In the absence of such written authorization, actions undertaken by the employment business/agency shall be deemed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or referrals. Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses incurred on your behalf in the event you are afforded an interview. This capture of applicable transfers of value is necessary to ensure GSK’s compliance with federal and state US transparency requirements. For more information, please visit the CMS Open Payments data site.
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