Merck
Principal Scientist, Drug Metabolism and Pharmacokinetics (REMOTE)
Merck, Bismarck, North Dakota, us, 58502
Position
Principal Scientist, Drug Metabolism and Pharmacokinetics (DMPK)
Location: West Point, Pennsylvania (remote). The remote position is only applicable for those that are not within commutable distance to primary sites noted in posting. Standard commute is less than 50 miles.
Job Overview The Pharmacokinetics, Dynamics, Metabolism, and Bioanalytics (PDMB) function of our Research & Development Division is seeking a dynamic and collaborative scientist to serve as a key contributor to multi‑disciplinary drug development and discovery efforts, providing an integrated understanding of DMPK properties, pharmacokinetics/pharmacodynamics (PK/PD), and drug interaction (DDI) risk of novel therapeutics.
Responsibilities
Work within cross‑functional teams to contribute to the discovery and clinical development of therapeutics across various modalities.
Guide the design and interpretation of in silico, in vitro, and in vivo analyses to support therapeutics with the desired DMPK profile.
Assess DDI risk using static mechanistic and/or physiologically‑based pharmacokinetic (PBPK) models and guide clinical development teams on DDI strategy.
Author source reports and documents for regulatory filings.
Evaluate and predict potential program risks, and implement appropriate strategies to address liabilities to ensure efficient program progression and decision making.
Qualifications
PhD or Master’s degree in Pharmaceutical Sciences, Pharmacology, Pharmacokinetics, Pharmacodynamics, Chemistry, Biomedical Engineering, Biochemistry, Toxicology, Biology, or relevant STEM fields.
Master’s degree with 10+ years relevant experience or PhD with 7+ years industry/applied drug discovery/development experience in a relevant field.
Experience integrating preclinical DMPK and pharmacology to enable translational modeling and simulation to support dose selection, PK/PD, safety assessment studies, and dose justifications for preclinical and clinical studies.
Experience assessing the impact of various factors on the PK/PD of novel therapeutics and communicating analyses and recommendations to interdisciplinary teams and management.
Experience authoring documents in support of IND, WMA filings, and responses to regulatory inquiries.
Strong leadership, interpersonal, communication, problem‑solving, and collaboration skills, delivering results on firm deadlines.
Demonstrated track record as an effective collaborator on multi-disciplinary discovery and development teams.
Preferred Experience and Skills
Strong publication track record.
Experience representing the DMPK function in evaluation of third‑party assets.
Experience building models and performing analyses using Phoenix, PBPK modeling software (e.g., SimCYP).
Experience mentoring or supervising junior staff.
EEO Statement As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities.
Benefits and Compensation Salary range: $169,700.00 – $267,200.00. Eligible for annual bonus and long‑term incentive, if applicable. Comprehensive benefits include medical, dental, vision, retirement 401(k), paid holidays, vacation, and compassionate and sick days.
Work Arrangements Remote (U.S. Hybrid Work Model: 3 days on‑site per week, Monday–Thursday; Friday remote, unless business critical). Travel requirement: ~10%.
Other Details Domestic relocation available. Visa sponsorship available. Requisition ID: R369246. Job posting end date: 10/23/2025.
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Location: West Point, Pennsylvania (remote). The remote position is only applicable for those that are not within commutable distance to primary sites noted in posting. Standard commute is less than 50 miles.
Job Overview The Pharmacokinetics, Dynamics, Metabolism, and Bioanalytics (PDMB) function of our Research & Development Division is seeking a dynamic and collaborative scientist to serve as a key contributor to multi‑disciplinary drug development and discovery efforts, providing an integrated understanding of DMPK properties, pharmacokinetics/pharmacodynamics (PK/PD), and drug interaction (DDI) risk of novel therapeutics.
Responsibilities
Work within cross‑functional teams to contribute to the discovery and clinical development of therapeutics across various modalities.
Guide the design and interpretation of in silico, in vitro, and in vivo analyses to support therapeutics with the desired DMPK profile.
Assess DDI risk using static mechanistic and/or physiologically‑based pharmacokinetic (PBPK) models and guide clinical development teams on DDI strategy.
Author source reports and documents for regulatory filings.
Evaluate and predict potential program risks, and implement appropriate strategies to address liabilities to ensure efficient program progression and decision making.
Qualifications
PhD or Master’s degree in Pharmaceutical Sciences, Pharmacology, Pharmacokinetics, Pharmacodynamics, Chemistry, Biomedical Engineering, Biochemistry, Toxicology, Biology, or relevant STEM fields.
Master’s degree with 10+ years relevant experience or PhD with 7+ years industry/applied drug discovery/development experience in a relevant field.
Experience integrating preclinical DMPK and pharmacology to enable translational modeling and simulation to support dose selection, PK/PD, safety assessment studies, and dose justifications for preclinical and clinical studies.
Experience assessing the impact of various factors on the PK/PD of novel therapeutics and communicating analyses and recommendations to interdisciplinary teams and management.
Experience authoring documents in support of IND, WMA filings, and responses to regulatory inquiries.
Strong leadership, interpersonal, communication, problem‑solving, and collaboration skills, delivering results on firm deadlines.
Demonstrated track record as an effective collaborator on multi-disciplinary discovery and development teams.
Preferred Experience and Skills
Strong publication track record.
Experience representing the DMPK function in evaluation of third‑party assets.
Experience building models and performing analyses using Phoenix, PBPK modeling software (e.g., SimCYP).
Experience mentoring or supervising junior staff.
EEO Statement As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities.
Benefits and Compensation Salary range: $169,700.00 – $267,200.00. Eligible for annual bonus and long‑term incentive, if applicable. Comprehensive benefits include medical, dental, vision, retirement 401(k), paid holidays, vacation, and compassionate and sick days.
Work Arrangements Remote (U.S. Hybrid Work Model: 3 days on‑site per week, Monday–Thursday; Friday remote, unless business critical). Travel requirement: ~10%.
Other Details Domestic relocation available. Visa sponsorship available. Requisition ID: R369246. Job posting end date: 10/23/2025.
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