GlaxoSmithKline
Director, Quantitative Systems Pharmacology, CPMS Oncology
GlaxoSmithKline, Cambridge, Massachusetts, us, 02140
Site Name:
USA - Pennsylvania - Upper Providence, USA - Massachusetts - Cambridge
Posted Date:
Oct 14 2025
Director, Quantitative Systems Pharmacology- CPMS Oncology At GSK, we combine our understanding of the immune system with cutting‑edge technology to bring new vaccines and medicines to patients and aim to positively impact the health of 2.5 billion people by the decade’s end. We foster a culture ambitious for patients, accountable for impact, and committed to doing the right thing.
**Position Summary** We are seeking a motivated and experienced professional to join GSK as Director, Quantitative Systems Pharmacology (QSP). In this role, you will lead the development and application of QSP models to guide clinical study designs and provide mechanistic insights into study results. You will collaborate across multidisciplinary teams to advance our understanding of disease mechanisms and therapeutic strategies. This is an opportunity to make a meaningful impact on drug development while growing your career in a supportive and innovative environment.
This position requires an on‑site office‑based presence 2 to 3 days a week in either the UK (London or Stevenage), Switzerland (Zug), the US (Upper Providence, PA. or Waltham, MA), or Poland (Warsaw).
Responsibilities
Develop and apply QSP models to inform clinical study designs and interpret study results.
Collaborate with multidisciplinary teams to integrate QSP approaches into drug development strategies.
Build and utilize models of biological and disease processes to evaluate drug candidates and treatment modalities.
Translate QSP analyses into actionable insights and communicate findings effectively to project teams and stakeholders.
Stay current with emerging modeling methodologies and contribute to the scientific community through publications and presentations.
Lead and mentor other QSP modelers, fostering collaboration and innovation.
Basic Qualifications
PhD in Applied Mathematics, Engineering, Pharmaceutical Sciences, or a related field.
Experience in developing and applying QSP approaches in drug discovery and development.
Proficiency in mathematical modeling, including ordinary differential equations and parameter estimation.
Hands‑on experience with modeling tools such as MATLAB, R, SimBiology, or similar platforms.
Knowledge of regulatory guidelines and their application in clinical study design.
Knowledge of pharmacokinetics, pharmacodynamics, and quantitative clinical pharmacology principles.
Strong communication skills and ability to work collaboratively in multidisciplinary teams.
Preferred Qualifications
Experience in oncology drug development.
Familiarity with advanced modeling approaches, such as mechanistic PK/PD modeling or adaptive dosing simulations.
Ability to summarize and present complex modeling outcomes to non‑expert audiences.
Demonstrated ability to innovate and contribute to scientific advancements in QSP.
Strong leadership skills and experience mentoring junior scientists.
We encourage you to apply if you are passionate about advancing science and making a difference in patients’ lives. Join us in uniting science, technology, and talent to get ahead of disease together.
GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.
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USA - Pennsylvania - Upper Providence, USA - Massachusetts - Cambridge
Posted Date:
Oct 14 2025
Director, Quantitative Systems Pharmacology- CPMS Oncology At GSK, we combine our understanding of the immune system with cutting‑edge technology to bring new vaccines and medicines to patients and aim to positively impact the health of 2.5 billion people by the decade’s end. We foster a culture ambitious for patients, accountable for impact, and committed to doing the right thing.
**Position Summary** We are seeking a motivated and experienced professional to join GSK as Director, Quantitative Systems Pharmacology (QSP). In this role, you will lead the development and application of QSP models to guide clinical study designs and provide mechanistic insights into study results. You will collaborate across multidisciplinary teams to advance our understanding of disease mechanisms and therapeutic strategies. This is an opportunity to make a meaningful impact on drug development while growing your career in a supportive and innovative environment.
This position requires an on‑site office‑based presence 2 to 3 days a week in either the UK (London or Stevenage), Switzerland (Zug), the US (Upper Providence, PA. or Waltham, MA), or Poland (Warsaw).
Responsibilities
Develop and apply QSP models to inform clinical study designs and interpret study results.
Collaborate with multidisciplinary teams to integrate QSP approaches into drug development strategies.
Build and utilize models of biological and disease processes to evaluate drug candidates and treatment modalities.
Translate QSP analyses into actionable insights and communicate findings effectively to project teams and stakeholders.
Stay current with emerging modeling methodologies and contribute to the scientific community through publications and presentations.
Lead and mentor other QSP modelers, fostering collaboration and innovation.
Basic Qualifications
PhD in Applied Mathematics, Engineering, Pharmaceutical Sciences, or a related field.
Experience in developing and applying QSP approaches in drug discovery and development.
Proficiency in mathematical modeling, including ordinary differential equations and parameter estimation.
Hands‑on experience with modeling tools such as MATLAB, R, SimBiology, or similar platforms.
Knowledge of regulatory guidelines and their application in clinical study design.
Knowledge of pharmacokinetics, pharmacodynamics, and quantitative clinical pharmacology principles.
Strong communication skills and ability to work collaboratively in multidisciplinary teams.
Preferred Qualifications
Experience in oncology drug development.
Familiarity with advanced modeling approaches, such as mechanistic PK/PD modeling or adaptive dosing simulations.
Ability to summarize and present complex modeling outcomes to non‑expert audiences.
Demonstrated ability to innovate and contribute to scientific advancements in QSP.
Strong leadership skills and experience mentoring junior scientists.
We encourage you to apply if you are passionate about advancing science and making a difference in patients’ lives. Join us in uniting science, technology, and talent to get ahead of disease together.
GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.
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