Pfizer
Director, Oncology Early-Stage Clinical Scientist
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Director, Oncology Early-Stage Clinical Scientist
role at
Pfizer .
Position Summary You will lead and coordinate the development of multiple studies of novel biological and small molecules for first‑in‑human (FIH), proof of mechanism (POM), early signs of efficacy (ESOE) and proof‑of‑concept (POC) studies in oncology.
You will work closely with the Global Development Lead (GDL) and the development team to establish, lead, coordinate, and execute the early oncology clinical development plan(s).
You will develop the clinical protocol and serve as an individual contributor on clinical teams with Pfizer development operations and the project team to meet enrollment and study‑delivery timelines.
In addition, you will collaborate with other functional disciplines to ensure the full scope and remit of Oncology Early‑Stage Development (OESD) is represented across clinical study teams including research units, biostatistics, clinical pharmacology, precision medicine, and digital medicine.
Position Responsibilities
Partner closely with the Global Development Lead (GDL) to execute the clinical development strategy and plan for the assigned molecule(s)/indication(s).
Provide scientific leadership and execution of clinical studies, delivering high‑quality trial execution, safety assessment, and interpretation of clinical study results.
Support execution for all FIH programs through proof‑of‑concept.
Set the clinical data review strategy, ensure quality data and conduct review of emerging clinical data and trends; present relevant data to appropriate teams, governance bodies, and stakeholders.
Conduct data review, analysis and interpretation of clinical trials data together with the GDL, Clinical Safety, and Biostatistics.
Serve as a technical resource for clinical issues raised by internal and external collaborators, investigators, consultants, and contractors.
Support and assist in the development of publications, abstracts, and presentations.
May sit on project teams to support clinical development implementation and contribution to key development milestones (e.g., start‑up and delivery of early signs of efficacy [ESoE] and POC trials).
Lead the preparation of clinical protocols and support other critical documents including clinical development plans, INDs, annual reports, CSRs, investigator brochures, statistical analysis plans, and regulatory documents.
Foster a transparent environment that builds strong partnerships and mutual trust among teams and therapeutic areas.
Coordinate with other clinical research activities within Oncology Research Development (ORD) and the broader Worldwide Research and Development (WRD) organization.
Develop effective collaborations with key internal and external partners such as research units, biostatistics, regulatory affairs, clinical pharmacology, human genetics, translational oncology, precision medicine, and development operations.
Partner with Translational Oncology and Biomarker teams to integrate biomarker plans into relevant programs for early efficacy signs and POC, and patient stratification.
Establish and support relationships with external experts, consultants, key opinion leaders, regulators, and investigator networks to integrate the latest clinical thinking and guidelines into development plans and study designs.
Maintain up‑to‑date knowledge of scientific and clinical literature in relevant therapeutic areas, including key clinical development issues.
Perform other duties as assigned related to clinical programs.
Support functional area priorities and contribute to or lead departmental initiatives as requested.
Minimum Qualifications / Key Skills
Relevant PhD or PharmD and a minimum of 5 years of experience in a similar role in industry/CRO.
MS and a minimum of 7 years of experience in a similar role in industry/CRO.
BA/BS and a minimum of 10 years of experience in a similar role in industry/CRO.
Clinical Research experience in Phase 1 oncology, on the side of the sponsor leading studies.
Experience or strong understanding of oncology drug development, especially in early development.
Strong knowledge of clinical procedures, ICH guidelines, GCP, and familiarity with FDA, EMA, and global regulations.
Strong scientific writing skills and communication skills (written and verbal).
Clinical document writing experience (protocols, ICD, IB, IND), and understanding of complex data analysis.
Track record of scientific productivity as evidenced by publications, posters, abstracts, and/or presentations.
Experience working with and solid understanding of related disciplines such as clinical operations, data management, safety, biostatistics, regulatory, study management, pre‑clinical, pharmacology, and quality assurance.
Experience building consensus and driving change across all levels of the organization, including senior management.
Data listing review experience.
Critical thinker, able to collaborate in a fast‑paced, matrixed environment while working independently when appropriate.
Experience performing complex data analyses using platforms such as JReview, SpotFire, SOCs‑PRO, or similar.
Preferred Qualifications
Experience leading a team.
Physical/Mental Requirements Perform complex data analysis.
Non‑Standard Work Schedule, Travel or Environment Requirements 5‑10% travel. Hybrid work location assignment.
Salary & Benefits The annual base salary ranges from $169,700.00 to $282,900.00.
The position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 20% of the base salary and long‑term incentive programs.
Benefits include a 401(k) plan with matching contributions, retirement savings contribution, paid vacation, holiday and personal days, caregiver/parental leave, and medical, prescription drug, dental, and vision coverage.
Relocation Assistance Relocation assistance may be available based on business needs and/or eligibility.
Sunshine Act Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations.
EEO & Employment Eligibility Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or expression, national origin, disability, or veteran status.
Pfizer complies with all applicable laws governing nondiscrimination and is an E‑Verify employer.
This position requires permanent work authorization in the United States.
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Director, Oncology Early-Stage Clinical Scientist
role at
Pfizer .
Position Summary You will lead and coordinate the development of multiple studies of novel biological and small molecules for first‑in‑human (FIH), proof of mechanism (POM), early signs of efficacy (ESOE) and proof‑of‑concept (POC) studies in oncology.
You will work closely with the Global Development Lead (GDL) and the development team to establish, lead, coordinate, and execute the early oncology clinical development plan(s).
You will develop the clinical protocol and serve as an individual contributor on clinical teams with Pfizer development operations and the project team to meet enrollment and study‑delivery timelines.
In addition, you will collaborate with other functional disciplines to ensure the full scope and remit of Oncology Early‑Stage Development (OESD) is represented across clinical study teams including research units, biostatistics, clinical pharmacology, precision medicine, and digital medicine.
Position Responsibilities
Partner closely with the Global Development Lead (GDL) to execute the clinical development strategy and plan for the assigned molecule(s)/indication(s).
Provide scientific leadership and execution of clinical studies, delivering high‑quality trial execution, safety assessment, and interpretation of clinical study results.
Support execution for all FIH programs through proof‑of‑concept.
Set the clinical data review strategy, ensure quality data and conduct review of emerging clinical data and trends; present relevant data to appropriate teams, governance bodies, and stakeholders.
Conduct data review, analysis and interpretation of clinical trials data together with the GDL, Clinical Safety, and Biostatistics.
Serve as a technical resource for clinical issues raised by internal and external collaborators, investigators, consultants, and contractors.
Support and assist in the development of publications, abstracts, and presentations.
May sit on project teams to support clinical development implementation and contribution to key development milestones (e.g., start‑up and delivery of early signs of efficacy [ESoE] and POC trials).
Lead the preparation of clinical protocols and support other critical documents including clinical development plans, INDs, annual reports, CSRs, investigator brochures, statistical analysis plans, and regulatory documents.
Foster a transparent environment that builds strong partnerships and mutual trust among teams and therapeutic areas.
Coordinate with other clinical research activities within Oncology Research Development (ORD) and the broader Worldwide Research and Development (WRD) organization.
Develop effective collaborations with key internal and external partners such as research units, biostatistics, regulatory affairs, clinical pharmacology, human genetics, translational oncology, precision medicine, and development operations.
Partner with Translational Oncology and Biomarker teams to integrate biomarker plans into relevant programs for early efficacy signs and POC, and patient stratification.
Establish and support relationships with external experts, consultants, key opinion leaders, regulators, and investigator networks to integrate the latest clinical thinking and guidelines into development plans and study designs.
Maintain up‑to‑date knowledge of scientific and clinical literature in relevant therapeutic areas, including key clinical development issues.
Perform other duties as assigned related to clinical programs.
Support functional area priorities and contribute to or lead departmental initiatives as requested.
Minimum Qualifications / Key Skills
Relevant PhD or PharmD and a minimum of 5 years of experience in a similar role in industry/CRO.
MS and a minimum of 7 years of experience in a similar role in industry/CRO.
BA/BS and a minimum of 10 years of experience in a similar role in industry/CRO.
Clinical Research experience in Phase 1 oncology, on the side of the sponsor leading studies.
Experience or strong understanding of oncology drug development, especially in early development.
Strong knowledge of clinical procedures, ICH guidelines, GCP, and familiarity with FDA, EMA, and global regulations.
Strong scientific writing skills and communication skills (written and verbal).
Clinical document writing experience (protocols, ICD, IB, IND), and understanding of complex data analysis.
Track record of scientific productivity as evidenced by publications, posters, abstracts, and/or presentations.
Experience working with and solid understanding of related disciplines such as clinical operations, data management, safety, biostatistics, regulatory, study management, pre‑clinical, pharmacology, and quality assurance.
Experience building consensus and driving change across all levels of the organization, including senior management.
Data listing review experience.
Critical thinker, able to collaborate in a fast‑paced, matrixed environment while working independently when appropriate.
Experience performing complex data analyses using platforms such as JReview, SpotFire, SOCs‑PRO, or similar.
Preferred Qualifications
Experience leading a team.
Physical/Mental Requirements Perform complex data analysis.
Non‑Standard Work Schedule, Travel or Environment Requirements 5‑10% travel. Hybrid work location assignment.
Salary & Benefits The annual base salary ranges from $169,700.00 to $282,900.00.
The position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 20% of the base salary and long‑term incentive programs.
Benefits include a 401(k) plan with matching contributions, retirement savings contribution, paid vacation, holiday and personal days, caregiver/parental leave, and medical, prescription drug, dental, and vision coverage.
Relocation Assistance Relocation assistance may be available based on business needs and/or eligibility.
Sunshine Act Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations.
EEO & Employment Eligibility Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or expression, national origin, disability, or veteran status.
Pfizer complies with all applicable laws governing nondiscrimination and is an E‑Verify employer.
This position requires permanent work authorization in the United States.
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