Eli Lilly and Company
Advisor - Protein Engineering (Biotechnology Discovery Research)
Eli Lilly and Company, San Diego, California, United States, 92189
Advisor - Protein Engineering (Biotechnology Discovery Research)
Eli Lilly and Company is seeking an Advisor for Protein Engineering within the Biotechnology Discovery Research group in San Diego. The role focuses on discovering, designing, and engineering protein therapeutics to optimize biological function, potency, time action, stability, developability, and immunogenicity, with opportunities to engineer proteins and/or antibodies for targeted delivery of bioconjugates or nucleic acids to cells. Responsibilities Design, engineer, and optimize novel protein therapeutics using structure-guided and experimental/library approaches to improve function and developability. Apply knowledge of protein structure–function and structure–activity relationships to guide molecular engineering efforts. Lead independent research projects from concept to execution, critically analyze results, draw conclusions, and identify new strategies for design and optimization. Troubleshoot complex challenges in protein engineering and develop innovative solutions. Advance core capabilities in antibody and protein engineering and contribute to new platform technologies. Collaboration & Leadership Serve as a protein engineering lead on cross-functional project teams with computational biology, development, manufacturing, and translational groups. Present research findings at internal meetings and contribute to scientific publications and regulatory documents as appropriate. Mentor junior scientists and research associates to support technical development and career growth. Stay current with emerging scientific trends and maintain awareness of the competitive landscape in biologics discovery. Basic Qualifications Ph.D. in protein engineering, protein biochemistry, structural biology, protein biophysics, molecular biology, or related field. Strong foundation in protein structure and function, with demonstrated success in rational design and experimental approaches in affinity, function, or stability engineering. Proficiency in computational tools for structure modeling and analysis (e.g., Rosetta, Schrödinger, Chimera, PyMOL, MOE, AlphaFold). Hands-on experience in molecular cloning and protein engineering. Additional Preferences Postdoctoral or industry experience in protein engineering or structural biology. Basic proficiency in Python and/or R for data analysis and workflow automation. Proven scientific productivity (first-author publications, patents, or conference presentations). Analytical and problem-solving skills with attention to detail. Effective written and verbal communication and a collaborative, team-oriented mindset. Comprehensive knowledge in protein sciences, structural biology, protein-protein interactions, and SAR. Experience with library design and screening (e.g., phage or yeast display). Understanding of antibody generation and biologics drug discovery; exposure to AI/machine learning in protein design is a plus. Commitment to diversity, equity, and inclusion; ability to thrive in a fast-paced, dynamic research environment; strong organizational and multitasking skills. Ability to collaborate with cross-functional teams across geographies; proficiency with scientific software and Microsoft Office. About Lilly and Employment Details Lilly is committed to providing equal opportunities and supports accommodations for candidates requiring accessibility during the application process. Lilly is an EEO employer. Compensation and benefits vary by education, experience, and location, with a range to be determined at hire. Job location: San Diego, CA. Seniority level: Mid-Senior level. Employment type: Full-time. Job function: Management and Manufacturing. Industry: Pharmaceutical Manufacturing.
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Eli Lilly and Company is seeking an Advisor for Protein Engineering within the Biotechnology Discovery Research group in San Diego. The role focuses on discovering, designing, and engineering protein therapeutics to optimize biological function, potency, time action, stability, developability, and immunogenicity, with opportunities to engineer proteins and/or antibodies for targeted delivery of bioconjugates or nucleic acids to cells. Responsibilities Design, engineer, and optimize novel protein therapeutics using structure-guided and experimental/library approaches to improve function and developability. Apply knowledge of protein structure–function and structure–activity relationships to guide molecular engineering efforts. Lead independent research projects from concept to execution, critically analyze results, draw conclusions, and identify new strategies for design and optimization. Troubleshoot complex challenges in protein engineering and develop innovative solutions. Advance core capabilities in antibody and protein engineering and contribute to new platform technologies. Collaboration & Leadership Serve as a protein engineering lead on cross-functional project teams with computational biology, development, manufacturing, and translational groups. Present research findings at internal meetings and contribute to scientific publications and regulatory documents as appropriate. Mentor junior scientists and research associates to support technical development and career growth. Stay current with emerging scientific trends and maintain awareness of the competitive landscape in biologics discovery. Basic Qualifications Ph.D. in protein engineering, protein biochemistry, structural biology, protein biophysics, molecular biology, or related field. Strong foundation in protein structure and function, with demonstrated success in rational design and experimental approaches in affinity, function, or stability engineering. Proficiency in computational tools for structure modeling and analysis (e.g., Rosetta, Schrödinger, Chimera, PyMOL, MOE, AlphaFold). Hands-on experience in molecular cloning and protein engineering. Additional Preferences Postdoctoral or industry experience in protein engineering or structural biology. Basic proficiency in Python and/or R for data analysis and workflow automation. Proven scientific productivity (first-author publications, patents, or conference presentations). Analytical and problem-solving skills with attention to detail. Effective written and verbal communication and a collaborative, team-oriented mindset. Comprehensive knowledge in protein sciences, structural biology, protein-protein interactions, and SAR. Experience with library design and screening (e.g., phage or yeast display). Understanding of antibody generation and biologics drug discovery; exposure to AI/machine learning in protein design is a plus. Commitment to diversity, equity, and inclusion; ability to thrive in a fast-paced, dynamic research environment; strong organizational and multitasking skills. Ability to collaborate with cross-functional teams across geographies; proficiency with scientific software and Microsoft Office. About Lilly and Employment Details Lilly is committed to providing equal opportunities and supports accommodations for candidates requiring accessibility during the application process. Lilly is an EEO employer. Compensation and benefits vary by education, experience, and location, with a range to be determined at hire. Job location: San Diego, CA. Seniority level: Mid-Senior level. Employment type: Full-time. Job function: Management and Manufacturing. Industry: Pharmaceutical Manufacturing.
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