MSD Malaysia
Manager, Clinical Research page is loaded## Manager, Clinical Researchremote type:
Not Applicablelocations:
CHN - Shanghai - Shanghai (Tower A)time type:
Full timeposted on:
Posted Todaytime left to apply:
End Date: December 31, 2025 (30+ days left to apply)job requisition id:
R354967Job Description**About the Role:**The position will provide domain expertise in modeling simulation to inform clinical pharmacology and drug development support of the company's pipeline. This position will interact with clinical pharmacology leads and other members of cross-disciplinary teams in support of multiple early- and late-stage programs. This position is expected to execute modeling and simulation strategy through a combination of direct contributions and collaborations with pharmacometrics experts in company headquarters.As a technical expert, this individual will utilize a variety of analytic software to integrate PK drug concentration-time measures, pharmacodynamic responses, and clinical safety and efficacy information for PK/PD and modeling and simulation (M&S) analyses. This individual will perform high-quality PMx analyses, including population PK modeling, PK-PD modeling, exposure-response analysis, and PBPK modeling to inform critical dose selection decisions in the early clinical development and support late development for regulatory filing.**Candidate Requirements:*** Ph.D. in pharmacometrics, pharmaceutical sciences, or related discipline with 2-4 (Manager) or 5+ (Sr. Manager) years of post-doctoral experience in a similar role in pharmaceutical drug development or academia.* Expertise in pharmacometrics (like model-based meta-analysis, dose-response and exposure-response analyses, disease modelling, machine learning methods) with ability to understand how model-informed drug discovery can support regulatory decisions* Deep knowledge of drug development, pharmacokinetics and pharmacology and basic science skills required* Team spirit, bright, persistent, organized, and flexible.* Fluent in both English and Chinese (oral and written).* Proficiency in at least two of the following languages: NONMEM, R, Matlab/ SimBiology**Preferred Requirements:*** industry experience in drug development is preferred**Required Skills:**Clinical Pharmacology, Drug Discovery Process, Good Clinical Practice (GCP), ICH GCP Guidelines, Machine Learning Algorithms, Pharmaceutical Research, Pharmaceutical Sciences, Pharmacodynamics, Pharmacokinetics, Pharmacotherapeutics, PKPD Modeling, Root Cause Analysis (RCA)**Preferred Skills:**Current Employees applyCurrent Contingent Workers apply**Search Firm Representatives Please Read Carefully**
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company.
No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.**Employee Status:**Regular**Relocation:**No relocation**VISA Sponsorship:**No**Travel Requirements:**No Travel Required**Flexible Work Arrangements:**Not Applicable**Shift:**Not Indicated**Valid Driving License:**No**Hazardous Material(s):**no**Job Posting End Date:**12/31/2025**\*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.** #J-18808-Ljbffr
Not Applicablelocations:
CHN - Shanghai - Shanghai (Tower A)time type:
Full timeposted on:
Posted Todaytime left to apply:
End Date: December 31, 2025 (30+ days left to apply)job requisition id:
R354967Job Description**About the Role:**The position will provide domain expertise in modeling simulation to inform clinical pharmacology and drug development support of the company's pipeline. This position will interact with clinical pharmacology leads and other members of cross-disciplinary teams in support of multiple early- and late-stage programs. This position is expected to execute modeling and simulation strategy through a combination of direct contributions and collaborations with pharmacometrics experts in company headquarters.As a technical expert, this individual will utilize a variety of analytic software to integrate PK drug concentration-time measures, pharmacodynamic responses, and clinical safety and efficacy information for PK/PD and modeling and simulation (M&S) analyses. This individual will perform high-quality PMx analyses, including population PK modeling, PK-PD modeling, exposure-response analysis, and PBPK modeling to inform critical dose selection decisions in the early clinical development and support late development for regulatory filing.**Candidate Requirements:*** Ph.D. in pharmacometrics, pharmaceutical sciences, or related discipline with 2-4 (Manager) or 5+ (Sr. Manager) years of post-doctoral experience in a similar role in pharmaceutical drug development or academia.* Expertise in pharmacometrics (like model-based meta-analysis, dose-response and exposure-response analyses, disease modelling, machine learning methods) with ability to understand how model-informed drug discovery can support regulatory decisions* Deep knowledge of drug development, pharmacokinetics and pharmacology and basic science skills required* Team spirit, bright, persistent, organized, and flexible.* Fluent in both English and Chinese (oral and written).* Proficiency in at least two of the following languages: NONMEM, R, Matlab/ SimBiology**Preferred Requirements:*** industry experience in drug development is preferred**Required Skills:**Clinical Pharmacology, Drug Discovery Process, Good Clinical Practice (GCP), ICH GCP Guidelines, Machine Learning Algorithms, Pharmaceutical Research, Pharmaceutical Sciences, Pharmacodynamics, Pharmacokinetics, Pharmacotherapeutics, PKPD Modeling, Root Cause Analysis (RCA)**Preferred Skills:**Current Employees applyCurrent Contingent Workers apply**Search Firm Representatives Please Read Carefully**
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company.
No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.**Employee Status:**Regular**Relocation:**No relocation**VISA Sponsorship:**No**Travel Requirements:**No Travel Required**Flexible Work Arrangements:**Not Applicable**Shift:**Not Indicated**Valid Driving License:**No**Hazardous Material(s):**no**Job Posting End Date:**12/31/2025**\*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.** #J-18808-Ljbffr