Dana-Farber Cancer Institute
Postdoctoral Research Fellow - Wolpin-Nowak Lab
Dana-Farber Cancer Institute, Boston, Massachusetts, us, 02298
Overview
The Dana-Farber Cancer Institute seeks a Research Fellow to focus on next-generation, translational pathology studies, working within the Wolpin-Nowak laboratory as part of the Hale Family Center for Pancreatic Cancer Research and the Lustgarten Foundation Pancreatic Cancer Research Laboratory at the Dana-Farber Cancer Institute. Our research group investigates the biology and risk factors associated with pancreatic and other gastrointestinal cancers. We aim to improve outcomes for patients with these diseases by identifying cancer earlier and by improving therapy. We focus on learning from cancer patients by studying human biospecimens so that discoveries can be translated rapidly and confidently into improved clinical care. Our laboratory includes epidemiologists, biostatisticians, pathologists, data scientists, molecular biologists, and clinical researchers. We employ a broad range of analysis approaches and techniques, including population-scale epidemiology studies, digital pathology, genomic sequencing, and spatial transcriptomic and protein profiling. Our tissue profiling work spans clinical trial correlative studies and landscape-directed discovery studies. We collaborate with the Gastrointestinal Cancer Center Biobank to acquire blood, tissue, and other sample types from Dana-Farber patients. We also collaborate with investigators at Dana-Farber and across the nation to study pancreatic cancer using model systems and to conduct and lead clinical trials. This position’s work location is
onsite, full-time on campus
in Boston, MA. Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life-changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS, and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health, particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow’s physician/researchers, and we collaborate with partners, including other Harvard Medical School-affiliated hospitals.
Responsibilities
Design and conduct studies using multiplex immunofluorescence, spatial transcriptional profiling, and other high-dimension tissue analysis approaches to evaluate pancreatic cancer pathology using human tissue specimens Assemble analysis pipelines using machine learning to process tissue data reproducibly and at scale Conduct analyses using programming languages such as R and Python Collaborate with other laboratory members with expertise in epidemiology, bioinformatics, pathology, molecular biology, and functional genomics Participate in group meetings and work collaboratively on larger projects with other group members Lead projects that result in first-author manuscripts Write grants and progress reports related to research funding
Qualifications
Candidates should hold a doctoral degree in genetics/genomics, cancer biology, pathology or related fields Multidisciplinary training and experience in multiple of these fields is desirable MD or MD-equivalent and PhD-holding candidates will both be considered; MD/PhD-holding candidates with pathology training are highly encouraged to apply Knowledge, Skills and Abilities
Strong background in human pathology Experience with traditional pathology laboratory techniques, including slide sectioning, H&E staining, immunohistochemistry and special stains a plus Experience with translational pathology techniques, including multiplexed immunofluorescence, spatial transcriptomics, and RNA in situ hybridization a plus Experience with digital image analysis platforms (Halo, VisioPharm, QuPath, InForm, etc.) a plus Experience with R, Python, and commonly used libraries/packages a plus Enthusiasm for novel assay and technology development Ability to independently analyze information and troubleshoot when required Excellent written and verbal communication skills Attention to detail and thoroughness in completing work tasks Ability to work within a team environment Adaptability to a fast-paced, dynamic environment Pay and Employment Details
Pay Transparency Statement The hiring range is based on market pay structures, with individual salaries determined by factors such as business needs, market conditions, internal equity, and based on the candidate’s relevant experience, skills and qualifications. For union positions, the pay range is determined by the Collective Bargaining Agreement (CBA). $72,000 - $76,385 At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong. We are committed to hiring faculty and staff who offer multifaceted experiences and strive to reduce the burden of cancer for all. If working in this organization inspires you, we encourage you to apply. Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other characteristics protected by law. EEOC Poster
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The Dana-Farber Cancer Institute seeks a Research Fellow to focus on next-generation, translational pathology studies, working within the Wolpin-Nowak laboratory as part of the Hale Family Center for Pancreatic Cancer Research and the Lustgarten Foundation Pancreatic Cancer Research Laboratory at the Dana-Farber Cancer Institute. Our research group investigates the biology and risk factors associated with pancreatic and other gastrointestinal cancers. We aim to improve outcomes for patients with these diseases by identifying cancer earlier and by improving therapy. We focus on learning from cancer patients by studying human biospecimens so that discoveries can be translated rapidly and confidently into improved clinical care. Our laboratory includes epidemiologists, biostatisticians, pathologists, data scientists, molecular biologists, and clinical researchers. We employ a broad range of analysis approaches and techniques, including population-scale epidemiology studies, digital pathology, genomic sequencing, and spatial transcriptomic and protein profiling. Our tissue profiling work spans clinical trial correlative studies and landscape-directed discovery studies. We collaborate with the Gastrointestinal Cancer Center Biobank to acquire blood, tissue, and other sample types from Dana-Farber patients. We also collaborate with investigators at Dana-Farber and across the nation to study pancreatic cancer using model systems and to conduct and lead clinical trials. This position’s work location is
onsite, full-time on campus
in Boston, MA. Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life-changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS, and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health, particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow’s physician/researchers, and we collaborate with partners, including other Harvard Medical School-affiliated hospitals.
Responsibilities
Design and conduct studies using multiplex immunofluorescence, spatial transcriptional profiling, and other high-dimension tissue analysis approaches to evaluate pancreatic cancer pathology using human tissue specimens Assemble analysis pipelines using machine learning to process tissue data reproducibly and at scale Conduct analyses using programming languages such as R and Python Collaborate with other laboratory members with expertise in epidemiology, bioinformatics, pathology, molecular biology, and functional genomics Participate in group meetings and work collaboratively on larger projects with other group members Lead projects that result in first-author manuscripts Write grants and progress reports related to research funding
Qualifications
Candidates should hold a doctoral degree in genetics/genomics, cancer biology, pathology or related fields Multidisciplinary training and experience in multiple of these fields is desirable MD or MD-equivalent and PhD-holding candidates will both be considered; MD/PhD-holding candidates with pathology training are highly encouraged to apply Knowledge, Skills and Abilities
Strong background in human pathology Experience with traditional pathology laboratory techniques, including slide sectioning, H&E staining, immunohistochemistry and special stains a plus Experience with translational pathology techniques, including multiplexed immunofluorescence, spatial transcriptomics, and RNA in situ hybridization a plus Experience with digital image analysis platforms (Halo, VisioPharm, QuPath, InForm, etc.) a plus Experience with R, Python, and commonly used libraries/packages a plus Enthusiasm for novel assay and technology development Ability to independently analyze information and troubleshoot when required Excellent written and verbal communication skills Attention to detail and thoroughness in completing work tasks Ability to work within a team environment Adaptability to a fast-paced, dynamic environment Pay and Employment Details
Pay Transparency Statement The hiring range is based on market pay structures, with individual salaries determined by factors such as business needs, market conditions, internal equity, and based on the candidate’s relevant experience, skills and qualifications. For union positions, the pay range is determined by the Collective Bargaining Agreement (CBA). $72,000 - $76,385 At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong. We are committed to hiring faculty and staff who offer multifaceted experiences and strive to reduce the burden of cancer for all. If working in this organization inspires you, we encourage you to apply. Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other characteristics protected by law. EEOC Poster
#J-18808-Ljbffr