GSK
Senior Medical Director - Respiratory Translational Medicine (Early Pipeline Uni
GSK, Collegeville, Pennsylvania, United States, 19426
Are you a leading expert in COPD, driven by a passion for transforming clinical insights into groundbreaking therapies and advancing early drug development? If so, the Senior Medical Director - Respiratory Translational Medicine role within GSK's Early Portfolio Unit offers an exciting opportunity to shape the future of COPD treatment and strategy.
GSK is seeking a Senior Medical Director - Respiratory Translational Medicine with deep expertise in chronic obstructive pulmonary disease (COPD) to join GSK's Early Portfolio Unit (EPU). The ideal candidate will bring a strong background in translational research and a proven record of accelerating the development of novel therapies. As a disease expert for COPD, you will co‑lead the COPD Disease Area Acceleration Team, supporting and driving the strategy for COPD and leading large matrix teams.
About RIIRU: The Respiratory, Immunology and Inflammation Research Unit (RIIRU) was formed in 2024 to identify and advance novel molecular targets with human genetic associations to disease. The remit of RIIRU is to identify novel targets, develop assets for clinical studies, and perform up to Phase 2 studies in clinic, leveraging both external (e.g., Flagship Pioneering, Vesalius, Muna Therapeutics) and internal partnerships.
Key Responsibilities:
Provide disease‑level leadership, developing causal maps of relevant pathobiology and the tools/instruments that enable timely experimentation and program prosecution.
Provide translational and clinical leadership for early translational and clinical development strategies for COPD programmes in the Early Pipeline Unit, ensuring designs align with IEP and CDP.
Stay abreast of advancements in respiratory research, clinical trial methodologies, and regulatory changes to maintain GSK's competitive edge.
Actively contribute to regulatory interactions, including briefing documents, presentations, and responses.
Contribute to Business Development activities, including due diligence projects.
Champion the implementation of translational and biomarker strategies across the early respiratory portfolio.
DAAT Leadership:
Co‑lead the COPD Disease Area Acceleration Team (DAAT), ensuring alignment of scientific and clinical strategies with business objectives through matrix leadership of large cross‑functional teams.
Drive the evaluation of therapeutic potential and clinical tractability of targets within the disease area.
Identify transformational opportunities where projects can offer significant benefits to patients.
Program Delivery:
Ensure quality, on‑time, and on‑budget delivery of studies and programs within a therapeutic area of EPU.
Design and implement experimental medicine studies to generate critical data.
Oversee risk assessment across programs and ensure implementation of mitigation strategies.
Collaboration and Matrix Working:
Collaborate with cross‑functional teams across the Advance Pipeline Unit, Commercial, Research Tech, and Development organisations.
Build and maintain networks across internal and external stakeholders, including academic institutions, CROs, and regulators.
Represent GSK effectively in external collaborations and negotiations.
Problem Solving and Decision Making:
Anticipate challenges and proactively develop strategies to mitigate risks.
Make decisions balancing risk/benefit with clear understanding of project impact.
Lead the writing and review of study‑related documents and regulatory submissions.
Communicate confidently and effectively at all levels, internally and externally.
Ways of Working:
Champion implementation of innovative business processes and strategies to improve clinical development outcomes.
Basic Qualifications:
Medical degree and clinical medical specialty training board qualification/registration in Respiratory Medicine/Pulmonary Medicine/Pulmonary & Critical Care.
Experience in the global pharmaceutical/biotechnology industry in the field of respiratory medicine, focusing on COPD.
Industry experience in respiratory/COPD clinical drug development, including translational medicine and early phase drug development.
Experience planning clinical development for an asset and/or indication.
Experience working with multiple stakeholders on complex projects.
Experience leading cross‑functional matrix teams within a clinical development setting.
Experience in translational medicine, clinical research methodology, and principles of biostatistics to facilitate innovative and efficient designs of clinical trials and development plans with clear data‑driven decision rules.
Preferred Qualifications/experience:
PhD in addition to medical degree and board qualification in Respiratory Medicine/Pulmonary Medicine/Pulmonary & Critical Care.
Strong leadership skills with proven ability to inspire high performance from cross‑functional teams.
Track record of building and maintaining strong relationships with internal and external stakeholders.
Proven record of creative problem solving in clinical trials and projects.
Transferable leadership qualities that support effective coaching, mentoring, and development experience.
Strong personal network across relevant scientific and clinical thought leaders, institutions, and consortia.
Future‑looking and experimental track record with demonstrable experience of tech‑enable solutions in biology, translation, or clinical development.
Why GSK? Uniting science, technology and talent to get ahead of disease together.
GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, growing a company where people can thrive. We focus on respiratory, immunology and inflammation; oncology; HIV; and infectious diseases to impact health at scale.
People and patients around the world count on the medicines and vaccines we make, so we're committed to creating an environment where our people can thrive and focus on what matters most. Our culture of ambition for patients, accountability for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.
GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information, military service or any basis prohibited under federal, state or local law.
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GSK is seeking a Senior Medical Director - Respiratory Translational Medicine with deep expertise in chronic obstructive pulmonary disease (COPD) to join GSK's Early Portfolio Unit (EPU). The ideal candidate will bring a strong background in translational research and a proven record of accelerating the development of novel therapies. As a disease expert for COPD, you will co‑lead the COPD Disease Area Acceleration Team, supporting and driving the strategy for COPD and leading large matrix teams.
About RIIRU: The Respiratory, Immunology and Inflammation Research Unit (RIIRU) was formed in 2024 to identify and advance novel molecular targets with human genetic associations to disease. The remit of RIIRU is to identify novel targets, develop assets for clinical studies, and perform up to Phase 2 studies in clinic, leveraging both external (e.g., Flagship Pioneering, Vesalius, Muna Therapeutics) and internal partnerships.
Key Responsibilities:
Provide disease‑level leadership, developing causal maps of relevant pathobiology and the tools/instruments that enable timely experimentation and program prosecution.
Provide translational and clinical leadership for early translational and clinical development strategies for COPD programmes in the Early Pipeline Unit, ensuring designs align with IEP and CDP.
Stay abreast of advancements in respiratory research, clinical trial methodologies, and regulatory changes to maintain GSK's competitive edge.
Actively contribute to regulatory interactions, including briefing documents, presentations, and responses.
Contribute to Business Development activities, including due diligence projects.
Champion the implementation of translational and biomarker strategies across the early respiratory portfolio.
DAAT Leadership:
Co‑lead the COPD Disease Area Acceleration Team (DAAT), ensuring alignment of scientific and clinical strategies with business objectives through matrix leadership of large cross‑functional teams.
Drive the evaluation of therapeutic potential and clinical tractability of targets within the disease area.
Identify transformational opportunities where projects can offer significant benefits to patients.
Program Delivery:
Ensure quality, on‑time, and on‑budget delivery of studies and programs within a therapeutic area of EPU.
Design and implement experimental medicine studies to generate critical data.
Oversee risk assessment across programs and ensure implementation of mitigation strategies.
Collaboration and Matrix Working:
Collaborate with cross‑functional teams across the Advance Pipeline Unit, Commercial, Research Tech, and Development organisations.
Build and maintain networks across internal and external stakeholders, including academic institutions, CROs, and regulators.
Represent GSK effectively in external collaborations and negotiations.
Problem Solving and Decision Making:
Anticipate challenges and proactively develop strategies to mitigate risks.
Make decisions balancing risk/benefit with clear understanding of project impact.
Lead the writing and review of study‑related documents and regulatory submissions.
Communicate confidently and effectively at all levels, internally and externally.
Ways of Working:
Champion implementation of innovative business processes and strategies to improve clinical development outcomes.
Basic Qualifications:
Medical degree and clinical medical specialty training board qualification/registration in Respiratory Medicine/Pulmonary Medicine/Pulmonary & Critical Care.
Experience in the global pharmaceutical/biotechnology industry in the field of respiratory medicine, focusing on COPD.
Industry experience in respiratory/COPD clinical drug development, including translational medicine and early phase drug development.
Experience planning clinical development for an asset and/or indication.
Experience working with multiple stakeholders on complex projects.
Experience leading cross‑functional matrix teams within a clinical development setting.
Experience in translational medicine, clinical research methodology, and principles of biostatistics to facilitate innovative and efficient designs of clinical trials and development plans with clear data‑driven decision rules.
Preferred Qualifications/experience:
PhD in addition to medical degree and board qualification in Respiratory Medicine/Pulmonary Medicine/Pulmonary & Critical Care.
Strong leadership skills with proven ability to inspire high performance from cross‑functional teams.
Track record of building and maintaining strong relationships with internal and external stakeholders.
Proven record of creative problem solving in clinical trials and projects.
Transferable leadership qualities that support effective coaching, mentoring, and development experience.
Strong personal network across relevant scientific and clinical thought leaders, institutions, and consortia.
Future‑looking and experimental track record with demonstrable experience of tech‑enable solutions in biology, translation, or clinical development.
Why GSK? Uniting science, technology and talent to get ahead of disease together.
GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, growing a company where people can thrive. We focus on respiratory, immunology and inflammation; oncology; HIV; and infectious diseases to impact health at scale.
People and patients around the world count on the medicines and vaccines we make, so we're committed to creating an environment where our people can thrive and focus on what matters most. Our culture of ambition for patients, accountability for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.
GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information, military service or any basis prohibited under federal, state or local law.
#J-18808-Ljbffr