GlaxoSmithKline
Senior Director Neurodegeneration, Translational Sciences
GlaxoSmithKline, Waltham, Massachusetts, United States, 02254
Overview
Senior Director Neurodegeneration, Translational Sciences At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting-edge technology to transform people’s lives. We are uniting science, technology, and talent to get ahead of disease together. Posting Location: UK - Hertfordshire - Stevenage; USA - Massachusetts - Waltham; USA - Pennsylvania - Upper Providence. This role is based in the United Kingdom or United States and will require on-site presence with flexibility for hybrid working arrangements. Reporting to the Vice President of Translational Sciences, Respiratory, Immunology and Inflammation Translational Unit (RIITU). The Senior Director will lead innovative disease-area translational initiatives to inform therapy-area and programme biomarker strategies, increasing the probability of success from preclinical to clinical transitions and enabling earlier, higher-confidence project-related decisions. Responsibilities include generation of foundational data and development/validation of disease biomarkers to support PoM, signs of clinical efficacy, PoC, and patient stratification by MoA to predict responder populations in neurodegenerative diseases. The successful candidate will collaborate with RIITU leadership, GSK matrix teams, and external partners, and will represent RIITU at governance levels. The role will drive initiatives leveraging single-cell technologies and advanced analytics in complex in vitro models, tissue biopsies, and organ models to deepen disease knowledge and inform target pathways and candidate molecule rationale grounded in human disease pathology. Responsibilities
Translational Leadership: Provide strategic leadership to understand disease areas and develop translational research strategies that support discovery and development of novel therapeutics, including evaluation and diligence of business development opportunities. Translational Innovation: Evaluate novel techniques and technologies (e.g., spatial transcriptomics) to inform translational initiatives, biomarker development and validation in collaboration with platform teams within a multi-functional matrix environment. Disease Biomarker Strategy Development: Partner with Disease Teams, Research Technologies and Development to establish disease biomarkers for decision making across clinical development, including identification, prioritization and validation of disease-relevant biomarkers, mechanistic/surrogate biomarkers, patient stratification, and deployment into clinical studies. Cross-functional Collaboration: Collaborate with Translational, Disease Teams, Human Genetics & Genomics, biology groups, biomarker platforms, Medicine Development Teams, HBSM, data-sciences, regulatory affairs, business development and commercial to ensure integration of translational research across the drug development lifecycle. External Partnerships: Establish and maintain strategic collaborations with academia, CROs, and external partners to access technologies, tools, reagents, biosamples, biomarker expertise, and research capabilities; foster a network of external experts and key opinion leaders; contribute to evaluation and diligence of business development opportunities. Matrix Leadership: Provide mentorship and professional development to the team; manage disease and project resources, budgets, and timelines to meet milestones and RIITU objectives; represent RIITU at portfolio governance reviews and provide input to pipeline and investment decisions. Qualifications
Basic Qualifications: Ph.D. in a relevant scientific discipline (e.g., Cell/Molecular Biology, Genetics, Pharmacology, Physical Chemistry or related field). Extensive Neurodegenerative disease translational science and biomarker development experience in the pharmaceutical/biotech industry. Strong track record as a translational/biomarker expert with publications and field contributions. Experience in a clinical trial setting, including authoring and oversight of clinical and regulatory documents. Knowledge of regulatory requirements, industry standards, and compliance in Translational Research and biomarker development. Proven ability to influence program decisions through biomarker strategies and translational insights supporting clinical progression milestones. Experience leading external collaborations and evaluating business development opportunities. Strong executive and people-management skills, with ability to prioritize and manage multiple projects to deadlines while ensuring high performance. Excellent inclusive matrix leadership with ability to foster psychological safety and motivate a team toward common goals. Adaptability to a fast-paced research environment with strong problem-solving and critical-thinking skills. Preferred Qualifications: If you have the following characteristics, it would be a plus: Awareness of bioinformatic/computational methods supporting integrated analysis of translational and biomarker data sets. Work Location: This role is based in the United Kingdom or United States and requires on-site presence with hybrid working options. Why GSK? Uniting science, technology and talent to get ahead of disease together. GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information, military service or any basis prohibited under federal, state or local law. We believe in an agile working culture for all roles. If flexibility is important, we encourage discussion with the hiring team about opportunities. Adjustments: If you require any adjustments to our process, contact UKRecruitment.Adjustments@gsk.com or 0808 234 4391. The helpline is available 8.30am–12.00 noon Monday to Friday (times may vary on bank holidays). Please note: this channel is for adjustments inquiries only. For other questions, refer to the UK Recruitment FAQ guide. Important notice to Employment businesses/Agencies GSK does not accept referrals from employment businesses/agencies without prior written authorization. See policy for details. For US, disclosure requirements may apply for healthcare professionals during interviews; information available at CMS Open Payments.
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Senior Director Neurodegeneration, Translational Sciences At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting-edge technology to transform people’s lives. We are uniting science, technology, and talent to get ahead of disease together. Posting Location: UK - Hertfordshire - Stevenage; USA - Massachusetts - Waltham; USA - Pennsylvania - Upper Providence. This role is based in the United Kingdom or United States and will require on-site presence with flexibility for hybrid working arrangements. Reporting to the Vice President of Translational Sciences, Respiratory, Immunology and Inflammation Translational Unit (RIITU). The Senior Director will lead innovative disease-area translational initiatives to inform therapy-area and programme biomarker strategies, increasing the probability of success from preclinical to clinical transitions and enabling earlier, higher-confidence project-related decisions. Responsibilities include generation of foundational data and development/validation of disease biomarkers to support PoM, signs of clinical efficacy, PoC, and patient stratification by MoA to predict responder populations in neurodegenerative diseases. The successful candidate will collaborate with RIITU leadership, GSK matrix teams, and external partners, and will represent RIITU at governance levels. The role will drive initiatives leveraging single-cell technologies and advanced analytics in complex in vitro models, tissue biopsies, and organ models to deepen disease knowledge and inform target pathways and candidate molecule rationale grounded in human disease pathology. Responsibilities
Translational Leadership: Provide strategic leadership to understand disease areas and develop translational research strategies that support discovery and development of novel therapeutics, including evaluation and diligence of business development opportunities. Translational Innovation: Evaluate novel techniques and technologies (e.g., spatial transcriptomics) to inform translational initiatives, biomarker development and validation in collaboration with platform teams within a multi-functional matrix environment. Disease Biomarker Strategy Development: Partner with Disease Teams, Research Technologies and Development to establish disease biomarkers for decision making across clinical development, including identification, prioritization and validation of disease-relevant biomarkers, mechanistic/surrogate biomarkers, patient stratification, and deployment into clinical studies. Cross-functional Collaboration: Collaborate with Translational, Disease Teams, Human Genetics & Genomics, biology groups, biomarker platforms, Medicine Development Teams, HBSM, data-sciences, regulatory affairs, business development and commercial to ensure integration of translational research across the drug development lifecycle. External Partnerships: Establish and maintain strategic collaborations with academia, CROs, and external partners to access technologies, tools, reagents, biosamples, biomarker expertise, and research capabilities; foster a network of external experts and key opinion leaders; contribute to evaluation and diligence of business development opportunities. Matrix Leadership: Provide mentorship and professional development to the team; manage disease and project resources, budgets, and timelines to meet milestones and RIITU objectives; represent RIITU at portfolio governance reviews and provide input to pipeline and investment decisions. Qualifications
Basic Qualifications: Ph.D. in a relevant scientific discipline (e.g., Cell/Molecular Biology, Genetics, Pharmacology, Physical Chemistry or related field). Extensive Neurodegenerative disease translational science and biomarker development experience in the pharmaceutical/biotech industry. Strong track record as a translational/biomarker expert with publications and field contributions. Experience in a clinical trial setting, including authoring and oversight of clinical and regulatory documents. Knowledge of regulatory requirements, industry standards, and compliance in Translational Research and biomarker development. Proven ability to influence program decisions through biomarker strategies and translational insights supporting clinical progression milestones. Experience leading external collaborations and evaluating business development opportunities. Strong executive and people-management skills, with ability to prioritize and manage multiple projects to deadlines while ensuring high performance. Excellent inclusive matrix leadership with ability to foster psychological safety and motivate a team toward common goals. Adaptability to a fast-paced research environment with strong problem-solving and critical-thinking skills. Preferred Qualifications: If you have the following characteristics, it would be a plus: Awareness of bioinformatic/computational methods supporting integrated analysis of translational and biomarker data sets. Work Location: This role is based in the United Kingdom or United States and requires on-site presence with hybrid working options. Why GSK? Uniting science, technology and talent to get ahead of disease together. GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information, military service or any basis prohibited under federal, state or local law. We believe in an agile working culture for all roles. If flexibility is important, we encourage discussion with the hiring team about opportunities. Adjustments: If you require any adjustments to our process, contact UKRecruitment.Adjustments@gsk.com or 0808 234 4391. The helpline is available 8.30am–12.00 noon Monday to Friday (times may vary on bank holidays). Please note: this channel is for adjustments inquiries only. For other questions, refer to the UK Recruitment FAQ guide. Important notice to Employment businesses/Agencies GSK does not accept referrals from employment businesses/agencies without prior written authorization. See policy for details. For US, disclosure requirements may apply for healthcare professionals during interviews; information available at CMS Open Payments.
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