Revolution Medicines
Senior Scientist I, Computational Chemistry
Revolution Medicines, San Francisco, California, United States, 94199
Senior Scientist I, Computational Chemistry
Join to apply for the
Senior Scientist I, Computational Chemistry
role at
Revolution Medicines .
Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit RAS-addicted cancers. The company’s R&D pipeline includes RAS(ON) Inhibitors and RAS Companion Inhibitors for combination treatment strategies. As a new member of the team, you will join other outstanding Revolutionaries committed to patients with cancers harboring mutations in the RAS signaling pathway.
The Opportunity We seek a motivated Senior Scientist I for our dynamic Computational Chemistry team. This position offers an exciting opportunity to drive drug discovery through cutting‑edge computational methods, working at the intersection of structural biology, medicinal chemistry, biology, and data science to accelerate the development of transformative therapeutics.
Responsibilities
Partner with multidisciplinary Discovery Sciences teams to design, optimize, and accelerate discovery of novel drug candidates using structure‑based computational methods.
Analyze SAR and make data‑driven decisions by following SAR trends to guide compound prioritization and design strategies for Ro5 and bRo5 molecules.
Collaborate closely with Medicinal Chemists to prioritize compound designs and communicate scientific rationale to interdisciplinary teams.
Design and implement virtual screening workflows leveraging structure‑based and ligand‑based methods to discover hit compounds and accelerate lead optimization.
Leverage advanced computational methodologies, including physics‑based, generative models, and machine‑learning approaches, to enhance understanding of SAR and drive Ro5/bRo5 projects.
Provide innovative ideas and models to challenge and guide project roadmap while serving as lead computational chemistry representative on drug discovery pipeline projects.
Devise and execute strategies to augment hit finding for novel protein and protein‑protein targets, aiding in designing diverse chemical libraries.
Required Skills, Experience and Education
Ph.D. in computational chemistry or related field and 5‑8 years of related experience (may include postdoctoral experience).
3+ years of computational chemistry experience in biotech/pharma with a strong track record demonstrated by publications, patents, and/or presentations.
Expert‑level knowledge of contemporary computational chemistry methods: docking, virtual screening, pharmacophore modeling, MD simulation, QM calculations, etc.
In-depth experience with cheminformatics, data science, machine‑learning software.
Scientific programming or scripting in Bash, Python, R, Java, C, or similar.
Excellent oral and written communication skills; experience influencing decisions and collaborating across multidisciplinary environments.
Driven by a desire to be innovative and creative in a high‑energy, fast‑paced environment.
Preferred Skills
Experience with Ro5 and bRo5 therapeutic modalities such as macrocycles and small molecules.
Working in HPC environments.
Strong publication history demonstrating computational chemistry expertise and innovation.
Familiarity with data visualization and analytics tools for effective communication of insights.
Compensation Base pay salary range for this full‑time position at our headquarters in Redwood City, CA is $144,000 — $180,000 USD. The range is one part of the overall total rewards program, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.
Equal Opportunity Employer Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.
Privacy Statement Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact privacy@revmed.com.
#J-18808-Ljbffr
Senior Scientist I, Computational Chemistry
role at
Revolution Medicines .
Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit RAS-addicted cancers. The company’s R&D pipeline includes RAS(ON) Inhibitors and RAS Companion Inhibitors for combination treatment strategies. As a new member of the team, you will join other outstanding Revolutionaries committed to patients with cancers harboring mutations in the RAS signaling pathway.
The Opportunity We seek a motivated Senior Scientist I for our dynamic Computational Chemistry team. This position offers an exciting opportunity to drive drug discovery through cutting‑edge computational methods, working at the intersection of structural biology, medicinal chemistry, biology, and data science to accelerate the development of transformative therapeutics.
Responsibilities
Partner with multidisciplinary Discovery Sciences teams to design, optimize, and accelerate discovery of novel drug candidates using structure‑based computational methods.
Analyze SAR and make data‑driven decisions by following SAR trends to guide compound prioritization and design strategies for Ro5 and bRo5 molecules.
Collaborate closely with Medicinal Chemists to prioritize compound designs and communicate scientific rationale to interdisciplinary teams.
Design and implement virtual screening workflows leveraging structure‑based and ligand‑based methods to discover hit compounds and accelerate lead optimization.
Leverage advanced computational methodologies, including physics‑based, generative models, and machine‑learning approaches, to enhance understanding of SAR and drive Ro5/bRo5 projects.
Provide innovative ideas and models to challenge and guide project roadmap while serving as lead computational chemistry representative on drug discovery pipeline projects.
Devise and execute strategies to augment hit finding for novel protein and protein‑protein targets, aiding in designing diverse chemical libraries.
Required Skills, Experience and Education
Ph.D. in computational chemistry or related field and 5‑8 years of related experience (may include postdoctoral experience).
3+ years of computational chemistry experience in biotech/pharma with a strong track record demonstrated by publications, patents, and/or presentations.
Expert‑level knowledge of contemporary computational chemistry methods: docking, virtual screening, pharmacophore modeling, MD simulation, QM calculations, etc.
In-depth experience with cheminformatics, data science, machine‑learning software.
Scientific programming or scripting in Bash, Python, R, Java, C, or similar.
Excellent oral and written communication skills; experience influencing decisions and collaborating across multidisciplinary environments.
Driven by a desire to be innovative and creative in a high‑energy, fast‑paced environment.
Preferred Skills
Experience with Ro5 and bRo5 therapeutic modalities such as macrocycles and small molecules.
Working in HPC environments.
Strong publication history demonstrating computational chemistry expertise and innovation.
Familiarity with data visualization and analytics tools for effective communication of insights.
Compensation Base pay salary range for this full‑time position at our headquarters in Redwood City, CA is $144,000 — $180,000 USD. The range is one part of the overall total rewards program, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.
Equal Opportunity Employer Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.
Privacy Statement Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact privacy@revmed.com.
#J-18808-Ljbffr