BioSpace
Job Description
Position:
Research Scientist
Location:
Cambridge, MA
Company:
Takeda Development Center Americas, Inc.
Job Type:
Full-time, with up to 20% remote work allowed.
Pay Range:
$111,800.00 – $191,600.00 per year.
Responsibilities
Contribute to discovery projects by independently designing and developing well-defined mechanistic experiments and projects within oncology immunotherapy research focusing on leveraging Vd1 T-cells as cancer treatment.
Lead from the lab to advance novel and differentiated products toward clinical milestones, working collaboratively with internal cross‑functional teams and external partners.
Design, execute, and interpret functional in vitro and ex vivo assays to understand therapeutic mechanism‑of‑action and participate in scientific discussions to drive decisions around Vd1 T‑cells.
Propose novel projects based on internal results, external partners, and published reports, demonstrating leadership through effective communication of study plans, value, and research results.
Actively participate with the team to isolate Vd1 cells from blood, tutor less experienced operators in complex procedures such as large‑scale Vd1 isolation from blood.
Use immune cell characterization and function assessments, including multi‑color flow immunophenotyping, multiplex cytokine measurement, cytotoxicity assays, and other molecular‑based assays and cell‑based functionality assays.
Contribute to evaluation of novel engagers for Vd1 T‑cells in vitro and ex vivo model systems, and develop new assays and strategies to determine Vd1 T‑cell functionality and biology to improve tumor control in presence of cell engagers.
Collaborate with other departments to meet deadlines and generate data crucial for program execution.
Contribute to the writing of relevant research reports for regulatory filings and prepare and present technical or project reports, formal presentations, and posters to internal and external audiences.
Maintain laboratory notebooks and keep in compliance with Takeda policies.
Requirements
PhD degree in Biology, Cancer Studies, or related field plus at least 3 years of related experience.
Experience isolating, culturing, and expanding Vd1 gamma‑delta T cells.
Design and execute in vitro/ex vivo assays of Vd1 cell function, including cytotoxicity, survival, and proliferation.
Analyze experimental data and determine relevance of results based on background knowledge of Vd1 gamma‑delta cell biology.
Contribute to evaluation of novel immunotherapy products based on Vd1 gamma‑delta cell biology.
Experience with gene engineering of Vd1 cells.
Qualified applicants can apply at
https://jobs.takeda.com . Please reference job #R0165592.
EOE
#J-18808-Ljbffr
Research Scientist
Location:
Cambridge, MA
Company:
Takeda Development Center Americas, Inc.
Job Type:
Full-time, with up to 20% remote work allowed.
Pay Range:
$111,800.00 – $191,600.00 per year.
Responsibilities
Contribute to discovery projects by independently designing and developing well-defined mechanistic experiments and projects within oncology immunotherapy research focusing on leveraging Vd1 T-cells as cancer treatment.
Lead from the lab to advance novel and differentiated products toward clinical milestones, working collaboratively with internal cross‑functional teams and external partners.
Design, execute, and interpret functional in vitro and ex vivo assays to understand therapeutic mechanism‑of‑action and participate in scientific discussions to drive decisions around Vd1 T‑cells.
Propose novel projects based on internal results, external partners, and published reports, demonstrating leadership through effective communication of study plans, value, and research results.
Actively participate with the team to isolate Vd1 cells from blood, tutor less experienced operators in complex procedures such as large‑scale Vd1 isolation from blood.
Use immune cell characterization and function assessments, including multi‑color flow immunophenotyping, multiplex cytokine measurement, cytotoxicity assays, and other molecular‑based assays and cell‑based functionality assays.
Contribute to evaluation of novel engagers for Vd1 T‑cells in vitro and ex vivo model systems, and develop new assays and strategies to determine Vd1 T‑cell functionality and biology to improve tumor control in presence of cell engagers.
Collaborate with other departments to meet deadlines and generate data crucial for program execution.
Contribute to the writing of relevant research reports for regulatory filings and prepare and present technical or project reports, formal presentations, and posters to internal and external audiences.
Maintain laboratory notebooks and keep in compliance with Takeda policies.
Requirements
PhD degree in Biology, Cancer Studies, or related field plus at least 3 years of related experience.
Experience isolating, culturing, and expanding Vd1 gamma‑delta T cells.
Design and execute in vitro/ex vivo assays of Vd1 cell function, including cytotoxicity, survival, and proliferation.
Analyze experimental data and determine relevance of results based on background knowledge of Vd1 gamma‑delta cell biology.
Contribute to evaluation of novel immunotherapy products based on Vd1 gamma‑delta cell biology.
Experience with gene engineering of Vd1 cells.
Qualified applicants can apply at
https://jobs.takeda.com . Please reference job #R0165592.
EOE
#J-18808-Ljbffr