Scorpion Therapeutics
Role Summary
We are seeking a highly skilled and motivated Senior Analytical Scientist to join our Analytical and Formulation Sciences team. The ideal candidate will have strong hands-on experience in UPLC method development, and mass spectrometry-based characterization of oligonucleotide and conjugates. This role is critical to supporting the development of innovative oligonucleotide-based therapeutics. This position will report into the Director, CMC. Based in Bedford, MA. Responsibilities
Develop, optimize, and validate UPLC methods for the analysis of oligonucleotides and their conjugates. Conduct mass spectrometry (LC-MS, HRMS, MS/MS) analyses to characterize oligonucleotide and its conjugates. Interpret analytical data to support product development, stability studies, and release testing. Collaborate with cross-functional teams including Process Development, Quality, and Regulatory Affairs. Author technical reports, method development summaries, and regulatory submissions (e.g., IND, BLA). Perform routine formulation preparation and characterization of oligonucleotide drug products for preclinical studies. Qualifications
Proven experience in UPLC method development for oligonucleotides or nucleic acid-based therapeutics. Strong expertise with mass spectrometry for structural and quantitative analysis of oligonucleotide and conjugates. Strong data analysis skills and proficiency with analytical software (e.g., Empower, MassLynx, Xcalibur). Excellent communication, documentation, and organizational skills. Ability to work independently and collaboratively in a fast-paced environment. Knowledge of ICH guidelines and regulatory expectations for analytical method validation. Education
Ph.D. in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or a related field with 6+ years of relevant industry experience; or M.S. with 10+ years of experience; or Bachelor's with 16+ years of experience. Additional Requirements
Travel: Approximately 5% travel.
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We are seeking a highly skilled and motivated Senior Analytical Scientist to join our Analytical and Formulation Sciences team. The ideal candidate will have strong hands-on experience in UPLC method development, and mass spectrometry-based characterization of oligonucleotide and conjugates. This role is critical to supporting the development of innovative oligonucleotide-based therapeutics. This position will report into the Director, CMC. Based in Bedford, MA. Responsibilities
Develop, optimize, and validate UPLC methods for the analysis of oligonucleotides and their conjugates. Conduct mass spectrometry (LC-MS, HRMS, MS/MS) analyses to characterize oligonucleotide and its conjugates. Interpret analytical data to support product development, stability studies, and release testing. Collaborate with cross-functional teams including Process Development, Quality, and Regulatory Affairs. Author technical reports, method development summaries, and regulatory submissions (e.g., IND, BLA). Perform routine formulation preparation and characterization of oligonucleotide drug products for preclinical studies. Qualifications
Proven experience in UPLC method development for oligonucleotides or nucleic acid-based therapeutics. Strong expertise with mass spectrometry for structural and quantitative analysis of oligonucleotide and conjugates. Strong data analysis skills and proficiency with analytical software (e.g., Empower, MassLynx, Xcalibur). Excellent communication, documentation, and organizational skills. Ability to work independently and collaboratively in a fast-paced environment. Knowledge of ICH guidelines and regulatory expectations for analytical method validation. Education
Ph.D. in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or a related field with 6+ years of relevant industry experience; or M.S. with 10+ years of experience; or Bachelor's with 16+ years of experience. Additional Requirements
Travel: Approximately 5% travel.
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