Boehringer Ingelheim GmbH
Post Doc - Electrophysiology & Sensor imaging of brain-obesity circuits
Boehringer Ingelheim GmbH, Germantown, Ohio, United States
Post Doc - Electrophysiology & Sensor Imaging of Brain-Obesity Circuits
This position is part time eligible with a minimum of 90%. This position is limited to 2 years. Note: To make it easier to find our job advertisements, we use the designation "Post Doc". This advertisement is addressed to all qualified candidates, not only to applicants directly after completing a doctorate. Overview
Join Us in Shaping the Future of Obesity Research. We are seeking a passionate and talented postdoctoral researcher who aims to uncover innovative therapeutic strategies for the treatment of obesity. We focus on in-depth investigation of critical neuronal and molecular mechanisms that could enhance and prolong the efficacy of anorexigenic therapeutics. Using cutting-edge technologies such as patch clamp and functional biosensor imaging in acute brain slices, you will explore how neuronal networks respond to pharmacological modulation. You will contribute to interdisciplinary discussions and help expand our fundamental understanding of brain-mediated control of energy homeostasis. Ready to make a difference? Apply now and be part of our journey toward transformative discoveries. Tasks & responsibilities
Investigate cellular and molecular changes in circumventricular brain areas during the development of obesity and in response to anti-obesity treatments. Explore single-cell sequencing datasets for markers that predict sustained suppression of food intake through neuronal and network responses. Establish and perform methods for AAV-mediated transduction of hypothalamic nuclei in mice, including labeling specific neuron populations and monitoring plastic network changes upon pharmacological treatments. Set up and execute experiments to study neuronal properties in hunger/satiety circuits using electrophysiology techniques, such as cell-attached or whole-cell patch clamp, and functional imaging in acute brain slices. Present findings at internal and external meetings and publish them in peer-reviewed journals. Collaborate in a multidisciplinary environment with cellular and molecular biologists, chemistry experts, electrophysiologists and pharmacologists. Requirements
PhD in biology, neuroscience, or related fields with in-depth knowledge in neuroscience. Extensive hands-on experience in whole-cell patch clamp and electrophysiology recordings in acute brain slices; background in recording hypothalamic and/or brainstem neurons is advantageous. Solid understanding of neurophysiology and experience in viral approaches to transduce rodent brain; stereotaxic surgery knowledge would be a plus. Demonstrated track record of publications in scientific journals. Ability to work in a drug-discovery oriented environment with multidisciplinary teams. Fluency in English (written and spoken); German language skills are desirable. Contact
If you have any questions about the job posting or process, please contact our HR Direct Team at +49 (0) 6132 77-3330 or via email: hr.de@boehringer-ingelheim.com. Recruitment process
Online application — The job posting is online until November 14, 2025. Virtual interview — Scheduled in the period from mid to end of November. On-site interviews — Beginning of December. Please include the following documents when applying:
Cover letter and CV
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This position is part time eligible with a minimum of 90%. This position is limited to 2 years. Note: To make it easier to find our job advertisements, we use the designation "Post Doc". This advertisement is addressed to all qualified candidates, not only to applicants directly after completing a doctorate. Overview
Join Us in Shaping the Future of Obesity Research. We are seeking a passionate and talented postdoctoral researcher who aims to uncover innovative therapeutic strategies for the treatment of obesity. We focus on in-depth investigation of critical neuronal and molecular mechanisms that could enhance and prolong the efficacy of anorexigenic therapeutics. Using cutting-edge technologies such as patch clamp and functional biosensor imaging in acute brain slices, you will explore how neuronal networks respond to pharmacological modulation. You will contribute to interdisciplinary discussions and help expand our fundamental understanding of brain-mediated control of energy homeostasis. Ready to make a difference? Apply now and be part of our journey toward transformative discoveries. Tasks & responsibilities
Investigate cellular and molecular changes in circumventricular brain areas during the development of obesity and in response to anti-obesity treatments. Explore single-cell sequencing datasets for markers that predict sustained suppression of food intake through neuronal and network responses. Establish and perform methods for AAV-mediated transduction of hypothalamic nuclei in mice, including labeling specific neuron populations and monitoring plastic network changes upon pharmacological treatments. Set up and execute experiments to study neuronal properties in hunger/satiety circuits using electrophysiology techniques, such as cell-attached or whole-cell patch clamp, and functional imaging in acute brain slices. Present findings at internal and external meetings and publish them in peer-reviewed journals. Collaborate in a multidisciplinary environment with cellular and molecular biologists, chemistry experts, electrophysiologists and pharmacologists. Requirements
PhD in biology, neuroscience, or related fields with in-depth knowledge in neuroscience. Extensive hands-on experience in whole-cell patch clamp and electrophysiology recordings in acute brain slices; background in recording hypothalamic and/or brainstem neurons is advantageous. Solid understanding of neurophysiology and experience in viral approaches to transduce rodent brain; stereotaxic surgery knowledge would be a plus. Demonstrated track record of publications in scientific journals. Ability to work in a drug-discovery oriented environment with multidisciplinary teams. Fluency in English (written and spoken); German language skills are desirable. Contact
If you have any questions about the job posting or process, please contact our HR Direct Team at +49 (0) 6132 77-3330 or via email: hr.de@boehringer-ingelheim.com. Recruitment process
Online application — The job posting is online until November 14, 2025. Virtual interview — Scheduled in the period from mid to end of November. On-site interviews — Beginning of December. Please include the following documents when applying:
Cover letter and CV
#J-18808-Ljbffr