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Energy Jobline ZR

Staff Systems Engineer in South San Francisco

Energy Jobline ZR, South San Francisco, California, us, 94083

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Cellares, a leading Integrated Development and Manufacturing Organization (IDMO), is seeking an innovative and highly motivated Staff Systems Engineer to contribute significantly to the development of cell therapy systems that have never been realized before.

The primary focus of this role is to apply a systems‑thinking approach and techniques to design and develop a first‑in‑its‑class instrument, collaborating with cross‑functional teams of engineers and scientists. As a Staff Systems Engineer, you will take ownership of a wide range of high‑value internal projects from requirements capture and architecture development to system prototyping, integration, and verification and validation activities. You will provide in‑depth analysis and help guide design reviews and architecture discussions, interfacing across many parts of the company.

Responsibilities

Responsible for developing, maintaining, and refining system requirements and architecture

Create and maintain documents, models & diagrams describing functional and physical decompositions, interface definitions, and flow diagrams

Responsible for developing, maintaining, and executing system and subsystem design verification protocols

Lead small project teams developing Cellares technology or testing strategies

Mentor junior members of the Systems Engineering team on best engineering practices

Support architecture definition by working with subsystem design teams to align overlapping design requirements, constraints, and drive teams in developing concepts, evaluating risks, and efficiently converging on a design path

Translate architectural concepts into prototypes, integrate them, analyze results, and iterate on the design

Work closely with product management to interpret customer, business, and compliance needs to define technical requirements

Develop system models that guide design decisions. These can include system tolerance budgets, performance models, COGS models, etc

Provide support to sub‑system engineers in the development of models that guide lower‑level design decisions

Develop test systems for internal use to support both R&D experiments and pilot build testing needs

Conduct design reviews and present fresh ideas, new technologies, and creative solutions to design problems

Using a structured approach for problem solving, lead teams through complex root‑cause analysis in which there are many possible root causes that involve various areas of physics and engineering

Requirements

Bachelor's, Master's, or PhD in Physics or Engineering with 10+ years of extensive and hands‑on experience in the development of analytical instrumentation, biotech automation, or similar is required

Hands‑on experience designing and integrating in the lab highly complex instrumentation prototypes that combine fluidic handling, electronic sensors, or robotics

Specific expertise in bioprocessing technologies involved in cell therapy manufacturing is highly desired

Working knowledge of requirements and risk management tools like JamaConnect, IBM Doors, TeamCenter, Orcanos, or Helix

Experience with MATLAB, Python, or high‑level scripting software for modeling, simulation, and data processing

Working knowledge of Statistical Design of Experiments, Data Analysis and Visualization, with SW tools such as JMP, Minitab, and Tableau

Excellent verbal, written, presentation, and interpersonal skills

Strong analytical and problem‑solving skills

Demonstrated track record of rapidly climbing steep learning curves

Prior experience working in ISO regulated environments (ISO 13485, ISO 14791)

Creative, self‑motivated, and flexible to work in a small company environment and assume a wide variety of tasks

Desire to be part of a rapidly evolving organization, with a compelling technology, and taking products and processes to the next level

Self‑awareness, integrity, authenticity, and a growth mindset

Cellares total compensation package contains competitive base salaries, highly subsidized Medical, Dental, and Vision Plans, 401(k) Matching, Free EV Charging, Onsite lunches, and Stock options. All displayed pay ranges are approximate, negotiable, and location dependent.

This is Cellares

Cellares is the first Integrated Development and Manufacturing Organization (IDMO) and takes an Industry 4.0 approach to mass manufacturing the living drugs of the 21st century. The company is both developing and operating integrated technologies for cell therapy manufacturing to accelerate access to life‑saving cell therapies. The company’s Cell Shuttle integrates all the technologies required for the entire manufacturing process in a flexible and high‑throughput platform that delivers true walk‑away, end‑to‑end automation. Cell Shuttles will be deployed in Cellares’ Smart Factories around the world to meet total patient demand for cell therapies at global scale. Partnering with Cellares enables academics, biotechs, and pharma companies to accelerate drug development and scale out manufacturing, lower process failure rates, lower manufacturing costs, and meet global patient demand. The company is headquartered in South San Francisco, California with its commercial‑scale IDMO Smart Factory in Bridgewater, New Jersey. The company is backed by world‑class investors and has raised over $355 million in financing. Leveling will be based on overall experience, education, and demonstration of knowledge throughout the interview process.

We may use artificial intelligence (AI) tools to support parts of the hiring process, such as reviewing applications, analyzing resumes, or assessing responses. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans. If you would like more information about how your data is processed, please contact us.

If you are interested in applying for this job, please press the Apply button and follow the application process.

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