Flagship Ventures
Pioneering Medicines: Director, Project Toxicology
Flagship Ventures, Cambridge, Massachusetts, us, 02140
What if...
We could harness the power of Flagship's scientific platforms and create novel treatment options that benefit more patients, sooner?
ABOUT PIONEERING MEDICINES
Pioneering Medicines, Flagship Pioneering's in-house drug development unit, is dedicated to conceiving and developing a broad portfolio of life-changing treatments for patients built from Flagship's innovative platforms. Harnessing the drug development expertise of its team together with the power of Flagship's multiple scientific platforms, Pioneering Medicines explores and identifies new product concepts which are then advanced jointly with Flagship's bioplatform companies. Within Flagship's Innovation Supply Chain partnerships, Pioneering Medicines works with external collaborators to apply its unique approach to partners' R&D priorities. These partnerships are highly co-creative strategic alliances that accelerate therapeutic innovation by bringing together partners spanning the full spectrum of drug discovery, development, and production.
THE ROLE
We are seeking a skilled and motivated Toxicologist to drive strategy and provide technical expertise in toxicology from discovery to development across our diverse drug discovery portfolio. The qualified candidate will provide project teams with toxicology strategy. We are seeking individuals who are analytical, goal-oriented and committed to maintaining the highest scientific and ethical standards. Strong communication skills and comfort working in a dynamic, cross-functional team environment are highly desirable.
This role will be based at our Cambridge, MA location. We have a hybrid model and onsite presence 3 times per week is required.
KEY RESPONSIBILITIES Serve as the project toxicologist for projects at various stages of discovery and development Conduct safety assessments (on- and off-target) Contribute to study design, planning, execution, and monitoring of external non-GLP and GLP toxicology studies (in vitro and in vivo) studies Contribute to the development of an in silico and in vitro screening strategy to understand potential toxicological liabilities for new modalities Manage contracts and coordinate activities with CROs for non-GLP and GLP toxicology studies Support the preparation of study reports with external labs Lead the preparation of regulatory documents, including INDs, investigator's brochures, and NDAs/BLAs Work closely with other functional areas such as biology, in vitro and in vivo pharmacology, DMPK, modeling and simulations, CMC and Clinical as well as internal and external collaborators PROFESSIONAL EXPERIENCE & QUALIFICATIONS
MA/MS in in toxicology, pharmacology, physiology, biology, immunology or related sciences PHD. in toxicology, pharmacology, physiology, biology, immunology or related discipline 5+ years experience in preclinical/nonclinical safety, pharmacology, and/or biology experience in the pharmaceutical/biotechnology industry Safety assessment experience (on- and off-target) Understanding of early discovery Toxicology and Regulatory Toxicology Project Toxicology strategy experience for small molecules, biologics and/or gene therapies DC moving to IND Ability to provide Toxicology expertise across a wide variety of Therapeutic areas such as Metabolism, Oncology, Immunology, Renal and Cardiovascular
ABOUT FLAGSHIP PIONEERING
Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.
Flagship has been recognized twice on FORTUNE's "Change the World" list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Learn more about Flagship at www.flagshippioneering.com.
At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact.
We are an equal opportunity employer . All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law.
We recognize that great candidates often bring unique strengths
without fulfilling every qualification . If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background
and interest in Flagship.
Recruitment & Staffing Agencies : Flagship Pioneering and its affiliated Flagship Lab companies (collectively, "FSP") do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.
#LI-TD1
The salary range for this role is $179,000 - $236,500. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Pioneering Medicines currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Pioneering Medicines's good faith estimate as of the date of publication and may be modified in the future.
We could harness the power of Flagship's scientific platforms and create novel treatment options that benefit more patients, sooner?
ABOUT PIONEERING MEDICINES
Pioneering Medicines, Flagship Pioneering's in-house drug development unit, is dedicated to conceiving and developing a broad portfolio of life-changing treatments for patients built from Flagship's innovative platforms. Harnessing the drug development expertise of its team together with the power of Flagship's multiple scientific platforms, Pioneering Medicines explores and identifies new product concepts which are then advanced jointly with Flagship's bioplatform companies. Within Flagship's Innovation Supply Chain partnerships, Pioneering Medicines works with external collaborators to apply its unique approach to partners' R&D priorities. These partnerships are highly co-creative strategic alliances that accelerate therapeutic innovation by bringing together partners spanning the full spectrum of drug discovery, development, and production.
THE ROLE
We are seeking a skilled and motivated Toxicologist to drive strategy and provide technical expertise in toxicology from discovery to development across our diverse drug discovery portfolio. The qualified candidate will provide project teams with toxicology strategy. We are seeking individuals who are analytical, goal-oriented and committed to maintaining the highest scientific and ethical standards. Strong communication skills and comfort working in a dynamic, cross-functional team environment are highly desirable.
This role will be based at our Cambridge, MA location. We have a hybrid model and onsite presence 3 times per week is required.
KEY RESPONSIBILITIES Serve as the project toxicologist for projects at various stages of discovery and development Conduct safety assessments (on- and off-target) Contribute to study design, planning, execution, and monitoring of external non-GLP and GLP toxicology studies (in vitro and in vivo) studies Contribute to the development of an in silico and in vitro screening strategy to understand potential toxicological liabilities for new modalities Manage contracts and coordinate activities with CROs for non-GLP and GLP toxicology studies Support the preparation of study reports with external labs Lead the preparation of regulatory documents, including INDs, investigator's brochures, and NDAs/BLAs Work closely with other functional areas such as biology, in vitro and in vivo pharmacology, DMPK, modeling and simulations, CMC and Clinical as well as internal and external collaborators PROFESSIONAL EXPERIENCE & QUALIFICATIONS
MA/MS in in toxicology, pharmacology, physiology, biology, immunology or related sciences PHD. in toxicology, pharmacology, physiology, biology, immunology or related discipline 5+ years experience in preclinical/nonclinical safety, pharmacology, and/or biology experience in the pharmaceutical/biotechnology industry Safety assessment experience (on- and off-target) Understanding of early discovery Toxicology and Regulatory Toxicology Project Toxicology strategy experience for small molecules, biologics and/or gene therapies DC moving to IND Ability to provide Toxicology expertise across a wide variety of Therapeutic areas such as Metabolism, Oncology, Immunology, Renal and Cardiovascular
ABOUT FLAGSHIP PIONEERING
Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.
Flagship has been recognized twice on FORTUNE's "Change the World" list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Learn more about Flagship at www.flagshippioneering.com.
At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact.
We are an equal opportunity employer . All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law.
We recognize that great candidates often bring unique strengths
without fulfilling every qualification . If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background
and interest in Flagship.
Recruitment & Staffing Agencies : Flagship Pioneering and its affiliated Flagship Lab companies (collectively, "FSP") do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.
#LI-TD1
The salary range for this role is $179,000 - $236,500. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Pioneering Medicines currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Pioneering Medicines's good faith estimate as of the date of publication and may be modified in the future.