The University of Texas MD Anderson Cancer Center
Flatiron Research Fellow, Structural & Molecular Biophysics and Biomolecula
The University of Texas MD Anderson Cancer Center, New York, New York, us, 10261
Job Title:
Flatiron Research Fellow, Structural & Molecular Biophysics and Biomolecular Design, Center for Computational Biology
Job Number:
108234
Location:
New York, US
Job Description
The Center for Computational Biology (CCB) at the Flatiron Institute is actively seeking enthusiastic, full‑time post‑doctoral Flatiron Research Fellows to join its Structural & Molecular Biophysics and Biomolecular Design groups for a joint appointment in 2026, as part of the Molecular Ensemble Sampling and Simulation (MESS) collaboration.
The goal at CCB is to advance the understanding of fundamental biological processes by developing theory, innovative modeling tools for large‑scale biophysical simulations, and computational frameworks for analyzing increasingly large experimental datasets. Living systems are built hierarchically; CCB’s research activities span several scales of biological organization, bridging microscopic detail and large‑scale behaviors, and providing continuity across its groups’ efforts. CCB currently comprises more than 45 research and data scientists at career stages from recent Ph.D. graduates through senior scientists, as well as visiting scientists, graduate students, interns, and support staff.
The Structural & Molecular Biophysics group uses long‑timescale molecular dynamics (MD) simulations, integrated with experimental observables (especially cryo‑EM data), and machine learning tools to better capture the dynamics of biological macromolecules and to understand their function. The Biomolecular Design group applies the theory of protein folding and function to design new, synthetic heteropolymers built from exotic chemical building blocks that fold into novel structures and perform new functions. Together, through MESS, the groups are advancing computational methods for the design and understanding of molecular motion, addressing obstacles to accuracy and tractability.
Successful candidates will carry out a research project advancing these goals. Particular foci include: engineering open‑source software infrastructure for analyzing macromolecular motion; integrating physics‑based simulation and machine learning methods; developing enhanced approximation methods (implicit solvation, coarse‑graining, etc.); incorporating molecular design tools to interpret cryo‑EM data; and designing molecules with potential medical interest. Strong applicants with backgrounds in computational biology/biochemistry/biophysics, applied and computational mathematics, computer science/engineering, machine learning, and related fields are particularly encouraged to apply.
Position Description Flatiron Research Fellows in CCB are individuals at the postdoctoral level with backgrounds in applied mathematics, statistics, computational biology, biophysics, computer science, engineering, mathematical physics, or related disciplines.
Fellows are expected to carry out an active research program that can be independently directed and/or involve substantial collaboration within CCB or the Flatiron Institute. In addition to research, Fellows help build the scientific community at CCB and the Flatiron Institute by participating in seminars, colloquia, and group meetings; developing their software, mathematical, and computational expertise through internal education opportunities; and sharing their knowledge through scientific publications, presentations, and/or software releases, with financial support from the Institute.
Responsibilities include but are not limited to:
Performing theoretical and computational research
Developing, implementing, and maintaining scientific software
Participating in the organization of CCB and Flatiron‑wide collaborative activities, including seminars, workshops, and meetings
Preparing manuscripts for publication and presenting at scientific conferences
Assisting in student mentorship
Sharing expertise and providing training and guidance to CCB staff and visitors as needed
FRF positions are generally two‑year appointments that can be renewed for a third year, contingent on performance. Fellows will be based at the Simons Foundation’s offices in New York City and may also be eligible for subsidized housing within walking distance of the Flatiron Institute.
For more information about careers at the Flatiron Institute, visit https://simonsfoundation.org/flatiron/careers.
Qualifications Education
Ph.D. in a relevant field (applied mathematics, statistics, computational biology, biophysics, computer science, engineering, mathematical physics, or related disciplines)
Related Skills & Other Requirements
Demonstrated abilities in mathematical modeling, analysis, and/or scientific computation, scientific software and algorithm development, data analysis and inference, and image analysis
Ability to conduct original and outstanding research in computational biology, including expertise in computational methods, data analysis, software and algorithm development, modeling, machine learning, and scientific simulation
Ability to work well in an interdisciplinary environment and collaborate with experimentalists
Strong oral and written communication, data documentation, and presentation skills
Compensation and Benefits
The full‑time annual compensation for this position is $91,000.
In addition to competitive salaries, the Simons Foundation provides an outstanding benefits package.
Application Instructions To apply, please submit the following via the application portal:
Cover Letter, which should include a summary of the applicant’s most significant contributions in graduate school
Curriculum vitae with publication list and, if relevant, links to software
Research statement (no more than three pages) describing the applicant’s past results, current and future interests, and potential synergies with activities at CCB
Two letters of recommendation
Applications for positions that begin in 2025 will generally be reviewed beginning November 2025 and will be considered on a rolling basis until the positions are filled. For full consideration, candidates are strongly encouraged to submit their complete application by November 30, 2025.
Selection Criteria
Past research accomplishments
Proposed research program
Synergy of the applicant’s expertise and proposal topic with existing CCB staff and research programs, and potential to cross boundaries between CCB groups and the Flatiron Institute’s other centers that are part of the MESS collaboration
Our Commitment to Expanding Pathways to Science & Opportunities for All Many of the greatest ideas and discoveries come from a diverse mix of minds, backgrounds, and experiences. The Simons Foundation is committed to advancing basic science and mathematics to benefit humankind and expand our collective understanding of our world. As part of our mission, we support partners, programs, and initiatives that seek to broaden the scientific community and open pathways to science and mathematics careers.
The Simons Foundation provides equal opportunities to all applicants without regard to race, religion, color, age, sex, pregnancy, national origin, sexual orientation, gender identity, genetic disposition, neurodiversity, disability, veteran status, or any other protected category under federal, state, and local law.
Application Deadline 2026-04-30
To apply, please visit https://apptrkr.com/6664826
#J-18808-Ljbffr
Flatiron Research Fellow, Structural & Molecular Biophysics and Biomolecular Design, Center for Computational Biology
Job Number:
108234
Location:
New York, US
Job Description
The Center for Computational Biology (CCB) at the Flatiron Institute is actively seeking enthusiastic, full‑time post‑doctoral Flatiron Research Fellows to join its Structural & Molecular Biophysics and Biomolecular Design groups for a joint appointment in 2026, as part of the Molecular Ensemble Sampling and Simulation (MESS) collaboration.
The goal at CCB is to advance the understanding of fundamental biological processes by developing theory, innovative modeling tools for large‑scale biophysical simulations, and computational frameworks for analyzing increasingly large experimental datasets. Living systems are built hierarchically; CCB’s research activities span several scales of biological organization, bridging microscopic detail and large‑scale behaviors, and providing continuity across its groups’ efforts. CCB currently comprises more than 45 research and data scientists at career stages from recent Ph.D. graduates through senior scientists, as well as visiting scientists, graduate students, interns, and support staff.
The Structural & Molecular Biophysics group uses long‑timescale molecular dynamics (MD) simulations, integrated with experimental observables (especially cryo‑EM data), and machine learning tools to better capture the dynamics of biological macromolecules and to understand their function. The Biomolecular Design group applies the theory of protein folding and function to design new, synthetic heteropolymers built from exotic chemical building blocks that fold into novel structures and perform new functions. Together, through MESS, the groups are advancing computational methods for the design and understanding of molecular motion, addressing obstacles to accuracy and tractability.
Successful candidates will carry out a research project advancing these goals. Particular foci include: engineering open‑source software infrastructure for analyzing macromolecular motion; integrating physics‑based simulation and machine learning methods; developing enhanced approximation methods (implicit solvation, coarse‑graining, etc.); incorporating molecular design tools to interpret cryo‑EM data; and designing molecules with potential medical interest. Strong applicants with backgrounds in computational biology/biochemistry/biophysics, applied and computational mathematics, computer science/engineering, machine learning, and related fields are particularly encouraged to apply.
Position Description Flatiron Research Fellows in CCB are individuals at the postdoctoral level with backgrounds in applied mathematics, statistics, computational biology, biophysics, computer science, engineering, mathematical physics, or related disciplines.
Fellows are expected to carry out an active research program that can be independently directed and/or involve substantial collaboration within CCB or the Flatiron Institute. In addition to research, Fellows help build the scientific community at CCB and the Flatiron Institute by participating in seminars, colloquia, and group meetings; developing their software, mathematical, and computational expertise through internal education opportunities; and sharing their knowledge through scientific publications, presentations, and/or software releases, with financial support from the Institute.
Responsibilities include but are not limited to:
Performing theoretical and computational research
Developing, implementing, and maintaining scientific software
Participating in the organization of CCB and Flatiron‑wide collaborative activities, including seminars, workshops, and meetings
Preparing manuscripts for publication and presenting at scientific conferences
Assisting in student mentorship
Sharing expertise and providing training and guidance to CCB staff and visitors as needed
FRF positions are generally two‑year appointments that can be renewed for a third year, contingent on performance. Fellows will be based at the Simons Foundation’s offices in New York City and may also be eligible for subsidized housing within walking distance of the Flatiron Institute.
For more information about careers at the Flatiron Institute, visit https://simonsfoundation.org/flatiron/careers.
Qualifications Education
Ph.D. in a relevant field (applied mathematics, statistics, computational biology, biophysics, computer science, engineering, mathematical physics, or related disciplines)
Related Skills & Other Requirements
Demonstrated abilities in mathematical modeling, analysis, and/or scientific computation, scientific software and algorithm development, data analysis and inference, and image analysis
Ability to conduct original and outstanding research in computational biology, including expertise in computational methods, data analysis, software and algorithm development, modeling, machine learning, and scientific simulation
Ability to work well in an interdisciplinary environment and collaborate with experimentalists
Strong oral and written communication, data documentation, and presentation skills
Compensation and Benefits
The full‑time annual compensation for this position is $91,000.
In addition to competitive salaries, the Simons Foundation provides an outstanding benefits package.
Application Instructions To apply, please submit the following via the application portal:
Cover Letter, which should include a summary of the applicant’s most significant contributions in graduate school
Curriculum vitae with publication list and, if relevant, links to software
Research statement (no more than three pages) describing the applicant’s past results, current and future interests, and potential synergies with activities at CCB
Two letters of recommendation
Applications for positions that begin in 2025 will generally be reviewed beginning November 2025 and will be considered on a rolling basis until the positions are filled. For full consideration, candidates are strongly encouraged to submit their complete application by November 30, 2025.
Selection Criteria
Past research accomplishments
Proposed research program
Synergy of the applicant’s expertise and proposal topic with existing CCB staff and research programs, and potential to cross boundaries between CCB groups and the Flatiron Institute’s other centers that are part of the MESS collaboration
Our Commitment to Expanding Pathways to Science & Opportunities for All Many of the greatest ideas and discoveries come from a diverse mix of minds, backgrounds, and experiences. The Simons Foundation is committed to advancing basic science and mathematics to benefit humankind and expand our collective understanding of our world. As part of our mission, we support partners, programs, and initiatives that seek to broaden the scientific community and open pathways to science and mathematics careers.
The Simons Foundation provides equal opportunities to all applicants without regard to race, religion, color, age, sex, pregnancy, national origin, sexual orientation, gender identity, genetic disposition, neurodiversity, disability, veteran status, or any other protected category under federal, state, and local law.
Application Deadline 2026-04-30
To apply, please visit https://apptrkr.com/6664826
#J-18808-Ljbffr