Revolution Medicines
Senior Safety Scientist
Revolution Medicines, San Francisco, California, United States, 94199
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Senior Safety Scientist
role at
Revolution Medicines .
Revolution Medicines is a clinical‑stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS‑addicted cancers. The company’s R&D pipeline comprises RAS(ON) Inhibitors and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will work with outstanding professionals committed to patients with cancers harboring mutations in the RAS signalling pathway.
The Opportunity The Senior Safety Scientist within Global Patient Safety Science is an individual contributor who provides safety science and pharmacovigilance support to all products across the RevMed portfolio, including early and late‑phase development activities. The role includes safety oversight of clinical studies, review and authoring of trial protocols, investigator brochures, informed consent forms, and DSURs. Additional activities involve medical review of individual case safety reports, safety surveillance of assigned products and active participation in cross‑functional teams.
Key Responsibilities
Proactive medical safety surveillance of ongoing clinical trials for identification and management of safety issues
Prepare and present safety data summaries to internal and external stakeholders
Conduct risk‑management activities including medical review of ICs, routine safety data review and scientific literature
Acquire and contribute knowledge of relevant drug class and/or competitor safety issues
Identify potential clinical safety issues and recommend risk‑mitigation measures
Prepare and maintain relevant sections of clinical trial protocols, investigator brochures, ICFs, DSURs, RMPs, CCDS, and labeling as required
Perform safety review of protocols, ICFs and related documents to ensure alignment with the safety strategy and risk‑communication plans
Accountable for the safety components of study reports (CSRs), publications, aggregate reports and other regulatory documents
Conduct signal detection and evaluation activities for assigned products to maintain continuous benefit‑risk assessment and support escalation to safety governance committees
Support implementation of decisions from the signal‑evaluation process, including updates to core safety information and key safety documents
Contribute to regulatory filings (NDAs, BLAs) and respond to safety queries from regulatory agencies
Establish and maintain collaborative relationships with study team members, CROs, investigators, study sites, vendors and committees
Consistently comply with governing laws, regulations, RevMed SOPs and other guidelines
Required Skills, Experience and Education
Relevant postgraduate qualification (MD, PharmD, PhD/MSc in Life Sciences or other post‑graduate health professional qualifications)
3+ years of drug development experience in the pharmaceutical or related industry with at least 1 year in drug safety
Proven success in building strong relationships with internal and external partners
Broad understanding of safety science, PV (including GVP, GCP), and clinical/patient risk‑management operations
Demonstrated ability to lead and influence with and without authority in a fast‑paced environment
Strong presentation skills and effective at summarizing key considerations and decision points
Collaborative team orientation and drive to deploy innovative approaches in a high‑energy environment
Detail‑oriented with ability to prioritize tasks and work independently as appropriate
Strong organizational skills and ability to interpret, discuss, and report trial‑level data and identify trends
Excellent written and verbal communication skills
Preferred Skills
Experience in oncology therapeutic area through clinical practice, drug development or relevant industry experience
In‑depth understanding of global pharmacovigilance regulations and guidelines (GVP, FDA, EMA)
Proficiency with pharmacovigilance databases and tools such as Argus and MedDRA coding
Track record in preparing and reviewing regulatory safety documents (NDAs, DSURs, RMPs)
Experience working across cross‑functional global teams including CRO partners
Strong analytical skills for safety data trend analysis and stakeholder communication
The base salary range for this full‑time position is $158,000 to $198,000 for candidates working onsite at our headquarters in Redwood City, CA. Base salary is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.
Revolution Medicines is an equal‑opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin, age, disability, marital status, medical condition, and veteran status.
Revolution Medicines respects data privacy and handles personal information in accordance with applicable laws and our CCPA Notice and Privacy Policy. For additional information, contact privacy@revmed.com.
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Senior Safety Scientist
role at
Revolution Medicines .
Revolution Medicines is a clinical‑stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS‑addicted cancers. The company’s R&D pipeline comprises RAS(ON) Inhibitors and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will work with outstanding professionals committed to patients with cancers harboring mutations in the RAS signalling pathway.
The Opportunity The Senior Safety Scientist within Global Patient Safety Science is an individual contributor who provides safety science and pharmacovigilance support to all products across the RevMed portfolio, including early and late‑phase development activities. The role includes safety oversight of clinical studies, review and authoring of trial protocols, investigator brochures, informed consent forms, and DSURs. Additional activities involve medical review of individual case safety reports, safety surveillance of assigned products and active participation in cross‑functional teams.
Key Responsibilities
Proactive medical safety surveillance of ongoing clinical trials for identification and management of safety issues
Prepare and present safety data summaries to internal and external stakeholders
Conduct risk‑management activities including medical review of ICs, routine safety data review and scientific literature
Acquire and contribute knowledge of relevant drug class and/or competitor safety issues
Identify potential clinical safety issues and recommend risk‑mitigation measures
Prepare and maintain relevant sections of clinical trial protocols, investigator brochures, ICFs, DSURs, RMPs, CCDS, and labeling as required
Perform safety review of protocols, ICFs and related documents to ensure alignment with the safety strategy and risk‑communication plans
Accountable for the safety components of study reports (CSRs), publications, aggregate reports and other regulatory documents
Conduct signal detection and evaluation activities for assigned products to maintain continuous benefit‑risk assessment and support escalation to safety governance committees
Support implementation of decisions from the signal‑evaluation process, including updates to core safety information and key safety documents
Contribute to regulatory filings (NDAs, BLAs) and respond to safety queries from regulatory agencies
Establish and maintain collaborative relationships with study team members, CROs, investigators, study sites, vendors and committees
Consistently comply with governing laws, regulations, RevMed SOPs and other guidelines
Required Skills, Experience and Education
Relevant postgraduate qualification (MD, PharmD, PhD/MSc in Life Sciences or other post‑graduate health professional qualifications)
3+ years of drug development experience in the pharmaceutical or related industry with at least 1 year in drug safety
Proven success in building strong relationships with internal and external partners
Broad understanding of safety science, PV (including GVP, GCP), and clinical/patient risk‑management operations
Demonstrated ability to lead and influence with and without authority in a fast‑paced environment
Strong presentation skills and effective at summarizing key considerations and decision points
Collaborative team orientation and drive to deploy innovative approaches in a high‑energy environment
Detail‑oriented with ability to prioritize tasks and work independently as appropriate
Strong organizational skills and ability to interpret, discuss, and report trial‑level data and identify trends
Excellent written and verbal communication skills
Preferred Skills
Experience in oncology therapeutic area through clinical practice, drug development or relevant industry experience
In‑depth understanding of global pharmacovigilance regulations and guidelines (GVP, FDA, EMA)
Proficiency with pharmacovigilance databases and tools such as Argus and MedDRA coding
Track record in preparing and reviewing regulatory safety documents (NDAs, DSURs, RMPs)
Experience working across cross‑functional global teams including CRO partners
Strong analytical skills for safety data trend analysis and stakeholder communication
The base salary range for this full‑time position is $158,000 to $198,000 for candidates working onsite at our headquarters in Redwood City, CA. Base salary is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.
Revolution Medicines is an equal‑opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin, age, disability, marital status, medical condition, and veteran status.
Revolution Medicines respects data privacy and handles personal information in accordance with applicable laws and our CCPA Notice and Privacy Policy. For additional information, contact privacy@revmed.com.
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