Merck
Job Description
Early Biologics Characterization- Protein Analytics group is seeking a highly motivated scientist with experience in a biopharmaceutical setting. The selected individual will join the Discovery Biologics group at our Company and will have exceptional organizational and interpersonal skills along with a solid background in life sciences. The successful candidate will play a key role in the characterization of protein-based therapeutics, supporting discovery and early development programs. This individual will be responsible for developing and applying state-of-the-art analytical techniques to assess protein identity, purity, structure, and stability such as SEC, HIC, CE-SDS, DSF, DLS, Buffer Exchange. The candidate will be expected to interface with other functional groups including in vitro display, molecular biology, and protein engineer functions. Good communication skills and the ability to present scientific data to multi-functional teams are critical.
This role will require an eagerness to learn and an ability to work with different teams and different equipment to operate a robust characterization platform. Your efforts will be a complement and core resource to existing capabilities and will serve to expand the team’s ability to interrogate biologics diversity to identify optimal leads. You will have the opportunity to apply your enthusiasm and technical skills as a member of Discovery Biologics - Boston to support and help drive multidisciplinary biotherapeutic discovery programs. This is a full-time, on-site position.
Responsibilities
Contribute to our Company's Discovery Biologics pipeline by generating high quality data for protein characterization including antigens, antibodies, and other fusions proteins.
Perform routine and advanced protein characterization using techniques such as HPLC/UPLC (SEC, IEX, RP), Capillary electrophoresis (CE-SDS, cIEF), LC‑MS.
Interpret and present analytical data to cross‑functional teams.
Collaborate closely with protein engineering, purification, and formulation teams to support candidate selection and optimization.
Follow and author technical reports, SOPs, and contribute to regulatory documentation as needed.
Maintain accurate and organized laboratory records in compliance with internal quality standards.
Serve as a functional area representative on program teams.
Promote the external reputation of our company’s Discovery Biologics organization.
Generate frequent characterization summary reports.
Troubleshoot automation methods and devices to maintain optimal high throughput protein analyses.
Qualifications and Experience
A minimum of a B.S. in a relevant field (e.g., protein sciences, biophysics, chemical or bioengineering, biochemistry, or related life sciences field) with additional training of 2 years of hands‑on industry experience, or a Master’s in Biochemistry or related discipline with 0‑1 years of experience.
Hands‑on experience with protein analytical techniques, especially chromatography‑based methods.
Familiarity with protein structure, post‑translational modifications, glycosylation.
Excellent problem‑solving skills and ability to work independently and collaboratively in a fast‑paced environment.
Required Skills
Familiarity with biophysical techniques (SEC; HIC, DSF, DSC, etc.) and their inherent data management.
Familiarity with LC‑MS workflows and sample preparation.
Ability to multitask, time management, and prioritize activities.
Excellent attention to detail and record keeping in electronic lab notebooks.
Excellent communication and collaboration skills.
Automated Liquid Handling Systems.
Biochemistry.
Biophysical Characterization.
Capillary Electrophoresis (CE).
Detail‑Oriented.
High‑Performance Liquid Chromatography (HPLC).
Liquid Chromatography‑Mass Spectrometry (LC‑MS).
Protein Analysis.
Protein Characterization.
Protein Expression.
Protein Purifications.
Proteins.
Size Exclusion Chromatography (SEC).
Therapeutics.
Ultra‑Performance Liquid Chromatography (UPLC).
Preferred Skills
Experience in other characterization workflows such as binding (SPR) or functional (cell‑based) assays.
Experience with EMPOWER is a plus.
Equal Employment Opportunity Statement As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a Federal Contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. Learn more about your rights, including under California, Colorado, and other U.S. State Acts. EEOC Know Your Rights. EEOC GINA Supplement.
U.S. & Puerto Rico residents only. Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that demonstrates their true capabilities. Please click here if you need an accommodation during the application or hiring process.
U.S. Hybrid Work Model Effective September 5, 2023, employees in office‑based positions in the U.S. will be working a hybrid model consisting of three total days on‑site per week (Monday – Thursday), although the specific days may vary by site or organization, with Friday designated as a remote‑working day, unless business‑critical tasks require an on‑site presence. This hybrid work model does not apply to field‑based, facility‑based, manufacturing‑based, or research‑based positions where the work is located at a Company site; positions covered by a collective‑bargaining agreement unless the agreement provides for hybrid work; or any other position where the Company determines the job requirements cannot be reasonably met working remotely.
Salary Range $96,100.00 – $151,200.00 (lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee’s position within the salary range will be based on several factors including, but not limited to, relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs.
Benefits We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare, and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits.
How to Apply You can apply for this role through https://jobs.merck.com/us/en (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting.
Eligibility San Francisco residents only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance.
Los Angeles residents only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance.
#J-18808-Ljbffr
This role will require an eagerness to learn and an ability to work with different teams and different equipment to operate a robust characterization platform. Your efforts will be a complement and core resource to existing capabilities and will serve to expand the team’s ability to interrogate biologics diversity to identify optimal leads. You will have the opportunity to apply your enthusiasm and technical skills as a member of Discovery Biologics - Boston to support and help drive multidisciplinary biotherapeutic discovery programs. This is a full-time, on-site position.
Responsibilities
Contribute to our Company's Discovery Biologics pipeline by generating high quality data for protein characterization including antigens, antibodies, and other fusions proteins.
Perform routine and advanced protein characterization using techniques such as HPLC/UPLC (SEC, IEX, RP), Capillary electrophoresis (CE-SDS, cIEF), LC‑MS.
Interpret and present analytical data to cross‑functional teams.
Collaborate closely with protein engineering, purification, and formulation teams to support candidate selection and optimization.
Follow and author technical reports, SOPs, and contribute to regulatory documentation as needed.
Maintain accurate and organized laboratory records in compliance with internal quality standards.
Serve as a functional area representative on program teams.
Promote the external reputation of our company’s Discovery Biologics organization.
Generate frequent characterization summary reports.
Troubleshoot automation methods and devices to maintain optimal high throughput protein analyses.
Qualifications and Experience
A minimum of a B.S. in a relevant field (e.g., protein sciences, biophysics, chemical or bioengineering, biochemistry, or related life sciences field) with additional training of 2 years of hands‑on industry experience, or a Master’s in Biochemistry or related discipline with 0‑1 years of experience.
Hands‑on experience with protein analytical techniques, especially chromatography‑based methods.
Familiarity with protein structure, post‑translational modifications, glycosylation.
Excellent problem‑solving skills and ability to work independently and collaboratively in a fast‑paced environment.
Required Skills
Familiarity with biophysical techniques (SEC; HIC, DSF, DSC, etc.) and their inherent data management.
Familiarity with LC‑MS workflows and sample preparation.
Ability to multitask, time management, and prioritize activities.
Excellent attention to detail and record keeping in electronic lab notebooks.
Excellent communication and collaboration skills.
Automated Liquid Handling Systems.
Biochemistry.
Biophysical Characterization.
Capillary Electrophoresis (CE).
Detail‑Oriented.
High‑Performance Liquid Chromatography (HPLC).
Liquid Chromatography‑Mass Spectrometry (LC‑MS).
Protein Analysis.
Protein Characterization.
Protein Expression.
Protein Purifications.
Proteins.
Size Exclusion Chromatography (SEC).
Therapeutics.
Ultra‑Performance Liquid Chromatography (UPLC).
Preferred Skills
Experience in other characterization workflows such as binding (SPR) or functional (cell‑based) assays.
Experience with EMPOWER is a plus.
Equal Employment Opportunity Statement As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a Federal Contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. Learn more about your rights, including under California, Colorado, and other U.S. State Acts. EEOC Know Your Rights. EEOC GINA Supplement.
U.S. & Puerto Rico residents only. Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that demonstrates their true capabilities. Please click here if you need an accommodation during the application or hiring process.
U.S. Hybrid Work Model Effective September 5, 2023, employees in office‑based positions in the U.S. will be working a hybrid model consisting of three total days on‑site per week (Monday – Thursday), although the specific days may vary by site or organization, with Friday designated as a remote‑working day, unless business‑critical tasks require an on‑site presence. This hybrid work model does not apply to field‑based, facility‑based, manufacturing‑based, or research‑based positions where the work is located at a Company site; positions covered by a collective‑bargaining agreement unless the agreement provides for hybrid work; or any other position where the Company determines the job requirements cannot be reasonably met working remotely.
Salary Range $96,100.00 – $151,200.00 (lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee’s position within the salary range will be based on several factors including, but not limited to, relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs.
Benefits We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare, and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits.
How to Apply You can apply for this role through https://jobs.merck.com/us/en (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting.
Eligibility San Francisco residents only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance.
Los Angeles residents only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance.
#J-18808-Ljbffr