Bullseye Biosciences
Platform Scientist – Automation & Synthetic Biology
Bullseye Biosciences, Boston, Massachusetts, us, 02298
Platform Scientist – Automation & Synthetic Biology
At Bullseye Biosciences, we evolve medicines inside living cells to unlock previously undruggable targets. We’re looking for innovators to help us build the future of therapeutic discovery.
Company Description Bullseye Biosciences is redefining how medicines are discovered by evolving them directly inside living cells. Our Archer Platform unites continuous directed evolution, synthetic gene circuits, and automation to discover genetically encoded macrocyclic peptides to unlock the potential of intracellular protein–protein interactions with unprecedented precision and scalability. Supported by leading biotech investors such as Illumina Ventures and advised by pioneering industry leaders including John Maraganore and Professor Jim Collins, Bullseye is translating cutting‑edge synthetic biology into real therapeutic impact. We’re applying this approach to high‑value targets across oncology, immunology, and metabolism, driven by a mission to redefine the scope of what is druggable.
Your expertise in automation, molecular biology, and NGS will not just advance our research, but also contribute significantly to the development of life‑changing treatments.
Role Description Come join us as a Platform and Automation Scientist in building a new generation of drugs against historically challenging targets using our directed evolution discovery engine!
This role will be instrumental in expanding our synthetic biology capabilities, deploying NGS capabilities for primary screening, and executing our screening campaigns against challenging targets. The Archer screening platform and subsequent hit testing relies on careful design of reporter "gene circuits" with multiple inducible components for precise control of the system. The role would help design, validate, and operate automation systems for high‑throughput evolution screening. Working with the Head of Research and Molecular Biology Team, you will be accountable for delivering from validation to meta‑analysis on our platform.
The Platform and Automation Scientist will be a key point person for establishing new methodologies and deploying our wetware and hardware for drug discovery screening. The screening itself leverages genetically encoded barcodes for NGS as a primary readout. This enables a platform scientist to run screening from design to output and analysis all on our robotics deck. You will also have the opportunity to continue supporting these targets through early drug discovery efforts and MOA. As a member of a small start‑up everyone makes major contributions to the direction and success of the company!
Key Qualifications and Responsibilities
Automation experience, especially preferred if prior lab work with Hamilton equipment
Knowledge of Python coding for operating and integrating labware
NGS library prep, processing, Illumina sequencer operation, and data analysis
Experience in PACE or similar directed evolution and 2-hybrid techniques in E coli systems
Molecular biology laboratory techniques including bacterial culture, PCR, cloning, protein blot analysis, assay development (TR‑FRET, ELISA, luminescence)
Attention to detail and accuracy in laboratory work including familiarity with ELN programs
Strong analytical and problem‑solving skills
Proficiency in data analysis and graphing software, including Graphpad, Spotfire, and Excel
Ability to work independently and as a team
PhD with at least 2 years of experience, or a Master’s degree with at least 4 years of experience, in synthetic biology or a related field
What we offer
Receive competitive salary and significant equity compensation, granting you a share in the company’s success and ownership in the innovations you help bring to life
Comprehensive health, dental, and vision insurance, a 401(k) plan, generous PTO, and other company benefits designed to support your well‑being inside and outside the lab
Contribution to the company at multiple levels and help drive its growth as part of the early founding team
Experience in an early start‑up environment with exposure to multiple facets of the business
Opportunities for exposure to numerous startups, founders and our world‑leading advisors within the thriving biotech environment
Application If you are ready to make a tangible impact on the future of drug discovery and thrive in a fast‑paced, innovative environment, we welcome you to apply and help shape the journey of Bullseye Biosciences!
We are committed to providing a workplace free of discrimination and harassment based on race, color, religion, age, gender, national origin, ancestry, physical or mental or sensory disability.
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Company Description Bullseye Biosciences is redefining how medicines are discovered by evolving them directly inside living cells. Our Archer Platform unites continuous directed evolution, synthetic gene circuits, and automation to discover genetically encoded macrocyclic peptides to unlock the potential of intracellular protein–protein interactions with unprecedented precision and scalability. Supported by leading biotech investors such as Illumina Ventures and advised by pioneering industry leaders including John Maraganore and Professor Jim Collins, Bullseye is translating cutting‑edge synthetic biology into real therapeutic impact. We’re applying this approach to high‑value targets across oncology, immunology, and metabolism, driven by a mission to redefine the scope of what is druggable.
Your expertise in automation, molecular biology, and NGS will not just advance our research, but also contribute significantly to the development of life‑changing treatments.
Role Description Come join us as a Platform and Automation Scientist in building a new generation of drugs against historically challenging targets using our directed evolution discovery engine!
This role will be instrumental in expanding our synthetic biology capabilities, deploying NGS capabilities for primary screening, and executing our screening campaigns against challenging targets. The Archer screening platform and subsequent hit testing relies on careful design of reporter "gene circuits" with multiple inducible components for precise control of the system. The role would help design, validate, and operate automation systems for high‑throughput evolution screening. Working with the Head of Research and Molecular Biology Team, you will be accountable for delivering from validation to meta‑analysis on our platform.
The Platform and Automation Scientist will be a key point person for establishing new methodologies and deploying our wetware and hardware for drug discovery screening. The screening itself leverages genetically encoded barcodes for NGS as a primary readout. This enables a platform scientist to run screening from design to output and analysis all on our robotics deck. You will also have the opportunity to continue supporting these targets through early drug discovery efforts and MOA. As a member of a small start‑up everyone makes major contributions to the direction and success of the company!
Key Qualifications and Responsibilities
Automation experience, especially preferred if prior lab work with Hamilton equipment
Knowledge of Python coding for operating and integrating labware
NGS library prep, processing, Illumina sequencer operation, and data analysis
Experience in PACE or similar directed evolution and 2-hybrid techniques in E coli systems
Molecular biology laboratory techniques including bacterial culture, PCR, cloning, protein blot analysis, assay development (TR‑FRET, ELISA, luminescence)
Attention to detail and accuracy in laboratory work including familiarity with ELN programs
Strong analytical and problem‑solving skills
Proficiency in data analysis and graphing software, including Graphpad, Spotfire, and Excel
Ability to work independently and as a team
PhD with at least 2 years of experience, or a Master’s degree with at least 4 years of experience, in synthetic biology or a related field
What we offer
Receive competitive salary and significant equity compensation, granting you a share in the company’s success and ownership in the innovations you help bring to life
Comprehensive health, dental, and vision insurance, a 401(k) plan, generous PTO, and other company benefits designed to support your well‑being inside and outside the lab
Contribution to the company at multiple levels and help drive its growth as part of the early founding team
Experience in an early start‑up environment with exposure to multiple facets of the business
Opportunities for exposure to numerous startups, founders and our world‑leading advisors within the thriving biotech environment
Application If you are ready to make a tangible impact on the future of drug discovery and thrive in a fast‑paced, innovative environment, we welcome you to apply and help shape the journey of Bullseye Biosciences!
We are committed to providing a workplace free of discrimination and harassment based on race, color, religion, age, gender, national origin, ancestry, physical or mental or sensory disability.
#J-18808-Ljbffr