Alnylam Pharmaceuticals
Overview
Alnylam Pharmaceuticals is seeking an imaginative physician drug developer, with the flexibility and confidence to work in therapeutic areas that may be beyond their particular expertise or experience. This is an opportunity to provide clinical leadership in developing RNAi therapeutics in Alnylam’s rapidly expanding portfolio, which spans from rare genetic to common diseases. The successful candidate’s primary role will be as one of the clinical leads in a clinical development program in ATTR amyloidosis. They will report to the program medical lead who provides clinical research oversight of the program. The role involves leading and influencing clinical development strategies for the molecules, driving progress and operational excellence for associated clinical trials, and collaborating with the research team to assess clinical development feasibility of novel targets and design proof-of-concept studies. It also includes extensive consultation and collaboration with external experts, with opportunities to lead bench-to-bedside early-phase clinical development programs. The Director, Clinical Research will work in a matrix organization across Regulatory, Biostatistics, Clinical Operations, Preclinical, Commercial & Quality Assurance teams to ensure harmonized development strategies and will serve as a key Alnylam Development spokesperson at external meetings, including regulatory interactions and scientific meetings. Key Responsibilities
Be the strategic leader providing a strong, clear voice for the clinical program. Develop creative but realistic approaches to drug development and lead clinical efforts to secure global regulatory approvals. Oversight of trial conduct and safety. Provide strategic consultation and guidance to Research on all decisions that have significant clinical components and implications. Collaborate closely with Preclinical, Regulatory Affairs and Medical Affairs to ensure tight strategic integration of product development plans. Be accountable via Clinical Research and Operations for all relevant timelines and deliverables. Supervise major written deliverables (regulatory submissions, original articles, abstracts) and presentation materials. Be responsible for final review and sign-off of controlled documents including protocols, investigator brochures, and informed consent forms. Influence internal and external audiences in a high-impact, highly visible fashion. Qualifications
MD with strong research background or MD/PhD with top-tier clinical and/or research training as shown through research support and peer-reviewed publications. Board Certification (or equivalent) or specialist training in cardiology or neurology is desirable. 3+ years industry experience or equivalent clinical academic experience. Sound scientific and clinical judgment. Familiarity with concepts of clinical research and clinical trial design, including biostatistics, and regulatory agency organization, guidelines, and practices. Ability to effectively present ideas and document complex medical/clinical concepts in both written and oral communication. History of solving problems with superior judgment and realistic understanding of issues. Outstanding leadership and collaboration skills in a matrix environment. Experience and knowledge of working with biotech/pharma partners. Thrives in a highly entrepreneurial biotech environment and embraces Alnylam’s culture of science, passion and urgency. U.S. Pay Range
$242,300.00 - $327,900.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on factors including relevant experience, skills, and education. This role is eligible for annual short-term and long-term incentive awards. Alnylam’s Total Rewards package supports overall health and well-being, including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending & health savings accounts, and a 401(k) with company match. Eligible employees receive paid time off, wellness days, holidays, and two company-wide recharge breaks. Our benefits aim to support you and your family. About Alnylam
We are the leader in RNAi therapeutics—transforming lives through Nobel Prize-winning science. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We are committed to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to sex, gender, race, color, ethnicity, national origin, ancestry, citizenship, religion, disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by law. Alnylam is an E-Verify Employer.
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Alnylam Pharmaceuticals is seeking an imaginative physician drug developer, with the flexibility and confidence to work in therapeutic areas that may be beyond their particular expertise or experience. This is an opportunity to provide clinical leadership in developing RNAi therapeutics in Alnylam’s rapidly expanding portfolio, which spans from rare genetic to common diseases. The successful candidate’s primary role will be as one of the clinical leads in a clinical development program in ATTR amyloidosis. They will report to the program medical lead who provides clinical research oversight of the program. The role involves leading and influencing clinical development strategies for the molecules, driving progress and operational excellence for associated clinical trials, and collaborating with the research team to assess clinical development feasibility of novel targets and design proof-of-concept studies. It also includes extensive consultation and collaboration with external experts, with opportunities to lead bench-to-bedside early-phase clinical development programs. The Director, Clinical Research will work in a matrix organization across Regulatory, Biostatistics, Clinical Operations, Preclinical, Commercial & Quality Assurance teams to ensure harmonized development strategies and will serve as a key Alnylam Development spokesperson at external meetings, including regulatory interactions and scientific meetings. Key Responsibilities
Be the strategic leader providing a strong, clear voice for the clinical program. Develop creative but realistic approaches to drug development and lead clinical efforts to secure global regulatory approvals. Oversight of trial conduct and safety. Provide strategic consultation and guidance to Research on all decisions that have significant clinical components and implications. Collaborate closely with Preclinical, Regulatory Affairs and Medical Affairs to ensure tight strategic integration of product development plans. Be accountable via Clinical Research and Operations for all relevant timelines and deliverables. Supervise major written deliverables (regulatory submissions, original articles, abstracts) and presentation materials. Be responsible for final review and sign-off of controlled documents including protocols, investigator brochures, and informed consent forms. Influence internal and external audiences in a high-impact, highly visible fashion. Qualifications
MD with strong research background or MD/PhD with top-tier clinical and/or research training as shown through research support and peer-reviewed publications. Board Certification (or equivalent) or specialist training in cardiology or neurology is desirable. 3+ years industry experience or equivalent clinical academic experience. Sound scientific and clinical judgment. Familiarity with concepts of clinical research and clinical trial design, including biostatistics, and regulatory agency organization, guidelines, and practices. Ability to effectively present ideas and document complex medical/clinical concepts in both written and oral communication. History of solving problems with superior judgment and realistic understanding of issues. Outstanding leadership and collaboration skills in a matrix environment. Experience and knowledge of working with biotech/pharma partners. Thrives in a highly entrepreneurial biotech environment and embraces Alnylam’s culture of science, passion and urgency. U.S. Pay Range
$242,300.00 - $327,900.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on factors including relevant experience, skills, and education. This role is eligible for annual short-term and long-term incentive awards. Alnylam’s Total Rewards package supports overall health and well-being, including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending & health savings accounts, and a 401(k) with company match. Eligible employees receive paid time off, wellness days, holidays, and two company-wide recharge breaks. Our benefits aim to support you and your family. About Alnylam
We are the leader in RNAi therapeutics—transforming lives through Nobel Prize-winning science. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We are committed to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to sex, gender, race, color, ethnicity, national origin, ancestry, citizenship, religion, disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by law. Alnylam is an E-Verify Employer.
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