BioMarin Pharmaceutical Inc.
Sr Scientist, BioPhysical Characterization & Bioconjugation, Lead
BioMarin Pharmaceutical Inc., San Francisco, California, United States, 94199
Sr Scientist, BioPhysical Characterization & Bioconjugation, Lead
BioMarin Pharmaceutical Inc. is seeking a Senior Scientist 1 – Biophysical Characterization & Bioconjugation to lead analytical strategy and experimental design for therapeutic proteins and their bioconjugates—particularly enzyme- and antibody-based platforms. You will join the Biologics Therapeutic Modality Team, developing advanced biophysical workflows, designing custom assays to define structure–function relationships, and guiding conjugation strategies for next-generation molecules. Your contributions will directly influence lead candidate selection, manufacturability, and regulatory readiness, helping advance promising therapies from bench to clinic.
BioMarin provided pay range This range is provided by BioMarin Pharmaceutical Inc.. Your actual pay will be based on your skills and experience — talk with your recruiter to learn more.
Base pay range $128,000.00/yr - $176,000.00/yr
BioMarin is a global biotechnology company that relentlessly pursues bold science to translate genetic discoveries into new medicines that advance the future of human health.
An Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability.
Qualifications
Ph.D. in Biophysics, Biochemistry, Pharmaceutical Sciences, or Chemical/Biomedical Engineering preferred. M.S. or B.S. with significant industry experience will be considered.
Experience: Ph.D. with 6+ years, M.S. with 10+ years, or B.S. with 12+ years of relevant experience in biophysical and analytical characterization of biologics.
Proven success with therapeutic protein conjugates (enzymes, antibodies, fusion proteins). Experience with small-molecule or nanoparticle conjugates is an advantage.
Technical Expertise: Working knowledge in at least one or two methods per category: Structure/Stability (DSC, DSF, CD, FTIR, HDX-MS), Binding/Mechanism (SPR, BLI, ITC, MST), Chromatography/Charge/Identity (HIC, IEX, RP-HPLC, CE-SDS, cIEF, LC-MS), Conjugation Analytics (DAR/DPR, linker/payload stability).
Regulatory & CMC: Experience contributing to IND/CTA filings and supporting method lifecycle management for complex biologics and conjugates.
Cross-Functional Collaboration: Partner with Discovery, Therapeutic Development, Analytical Sciences, Protein Engineering, Formulation, and Regulatory to integrate biophysical insights and support development decisions.
Delivery and Technology Transfer: Lead technology transfer of assays to Analytical Sciences or external partners (CROs/CDMOs) with proper SOPs and comparability plans.
Scientific Innovation & External Engagement: Stay current on bioconjugation and analytical biophysics innovations; evaluate emerging platforms to strengthen data quality and reduce program risk.
Mentorship & Culture Building: Act as a player-coach, mentoring junior scientists and promoting a culture of excellence, innovation, and accountability.
Seniority level Mid-Senior level
Employment type Full-time
Note: This description is not intended to be all-inclusive, or a limitation of the duties of the position. It is intended to describe the general nature of the job that may include other duties as assumed or assigned.
Don’t see a role you’re looking for? Please submit your resume for future consideration.
#J-18808-Ljbffr
BioMarin provided pay range This range is provided by BioMarin Pharmaceutical Inc.. Your actual pay will be based on your skills and experience — talk with your recruiter to learn more.
Base pay range $128,000.00/yr - $176,000.00/yr
BioMarin is a global biotechnology company that relentlessly pursues bold science to translate genetic discoveries into new medicines that advance the future of human health.
An Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability.
Qualifications
Ph.D. in Biophysics, Biochemistry, Pharmaceutical Sciences, or Chemical/Biomedical Engineering preferred. M.S. or B.S. with significant industry experience will be considered.
Experience: Ph.D. with 6+ years, M.S. with 10+ years, or B.S. with 12+ years of relevant experience in biophysical and analytical characterization of biologics.
Proven success with therapeutic protein conjugates (enzymes, antibodies, fusion proteins). Experience with small-molecule or nanoparticle conjugates is an advantage.
Technical Expertise: Working knowledge in at least one or two methods per category: Structure/Stability (DSC, DSF, CD, FTIR, HDX-MS), Binding/Mechanism (SPR, BLI, ITC, MST), Chromatography/Charge/Identity (HIC, IEX, RP-HPLC, CE-SDS, cIEF, LC-MS), Conjugation Analytics (DAR/DPR, linker/payload stability).
Regulatory & CMC: Experience contributing to IND/CTA filings and supporting method lifecycle management for complex biologics and conjugates.
Cross-Functional Collaboration: Partner with Discovery, Therapeutic Development, Analytical Sciences, Protein Engineering, Formulation, and Regulatory to integrate biophysical insights and support development decisions.
Delivery and Technology Transfer: Lead technology transfer of assays to Analytical Sciences or external partners (CROs/CDMOs) with proper SOPs and comparability plans.
Scientific Innovation & External Engagement: Stay current on bioconjugation and analytical biophysics innovations; evaluate emerging platforms to strengthen data quality and reduce program risk.
Mentorship & Culture Building: Act as a player-coach, mentoring junior scientists and promoting a culture of excellence, innovation, and accountability.
Seniority level Mid-Senior level
Employment type Full-time
Note: This description is not intended to be all-inclusive, or a limitation of the duties of the position. It is intended to describe the general nature of the job that may include other duties as assumed or assigned.
Don’t see a role you’re looking for? Please submit your resume for future consideration.
#J-18808-Ljbffr