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Chan Zuckerberg Initiative

Postdoctoral Fellow, Molecular Biology (Proteoform Spatial Biology Group - Biohu

Chan Zuckerberg Initiative, Chicago, Illinois, United States, 60290

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Postdoctoral Fellow, Molecular Biology (Proteoform Spatial Biology Group - Biohub Chicago) Join to apply for the

Postdoctoral Fellow, Molecular Biology (Proteoform Spatial Biology Group - Biohub Chicago)

role at

Chan Zuckerberg Initiative .

The

Chan Zuckerberg Biohub Chicago

(https://www.czbiohub.org/chi) is an independent nonprofit research institute that brings together Northwestern University, the University of Chicago, and the University of Illinois Urbana‑Champaign into a single collaborative technology and discovery engine. CZ Biohub supports bright engineers, data scientists, and biomedical researchers to make breakthroughs in medicine and develop new technologies in collaboration with partner universities. We are guided by values of scholarly excellence, disruptive innovation, hands‑on engineering, partnership, open communication, inclusiveness, and opportunity for all.

The Team We pursue large scientific challenges that cannot be pursued in conventional environments, enabling individual investigators to pursue their riskiest and most innovative ideas. The technologies developed at CZ Biohub Chicago facilitate research by scientists and clinicians at our partner institutions and beyond.

Our Vision

We pursue large scientific challenges that cannot be pursued in conventional environments

We enable individual investigators to pursue their riskiest and most innovative ideas

The technologies developed at CZ Biohub Chicago facilitate research by scientists and clinicians at our home institutions and beyond

Diversity of thought, ideas, and perspectives are at the heart of CZ Biohub Network and enable disruptive innovation and scholarly excellence. We are committed to cultivating an inclusive culture.

The Opportunity We are seeking outstanding early‑career scientists to join and participate in the launch of the Proteoform Spatial Biology Group by continuing their training as a

Postdoctoral Fellow in Molecular Biology . The group aims to uncover the spatiotemporal regulation of proteins and their unique molecular forms in inflammation and autoimmunity. For this position, the ideal candidate is expected to have experience working with primary human cell cultures and single‑cell nucleic‑acid sequencing‑based assays.

What You’ll Do

Culture, stimulate, and analyze human T‑cells from both primary sources and immortalized cell lines

Design and execute cutting‑edge spatial proteomic studies of inflammation and immune dysregulation using nucleic‑acid sequencing‑based techniques

Analyze and interpret results, contributing to collaborative datasets, manuscripts, and analyses

Present findings internally and externally

Co‑author publications

What You’ll Bring Essential

PhD in molecular biology, immunology, bioengineering, or a related field

Hands‑on experience with culturing and manipulating primary human T‑cells and immune cell lines

Proficiency with cytokine stimulation and immune functional assays

Strong experimental design and troubleshooting skills

Experience with nucleic‑acid sequencing‑based assays (e.g., molecular barcoding, library preparation for single‑cell RNA sequencing)

Ability to plan, execute, and troubleshoot complex experiments

Ability to work both collaboratively and independently

Nice to have

Familiarity with single‑cell technologies

Data analysis skills in R or Python

Experience coordinating cross‑lab collaborations

Experience in protein engineering or site‑directed mutagenesis

Experience with mass spectrometry‑and/or imaging‑based proteomics

Compensation The Chicago, IL base pay range for a new hire in this role is $75,000.00. New hires are typically hired into the lower portion of the range, enabling employee growth in the range over time. Actual placement in range is based on job‑related skills and experience, as evaluated throughout the interview process.

Benefits for the Whole You We’re thankful to have an incredible team behind our work. To honor their commitment, we offer a wide range of benefits to support the people who make all we do possible.

Provides a generous employer match on employee 401(k) contributions to support planning for the future

Paid time off to volunteer at an organization of your choice

Funding for select family‑forming benefits

Relocation support for employees who need assistance moving

If you’re interested in a role but your previous experience doesn’t perfectly align with each qualification in the job description, we still encourage you to apply as you may be the perfect fit for this or another role.

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