Ghent University
Overview
Postdoctoral Position in molecular and computational immunology The research group of Prof Tom Taghon at Ghent University in Belgium is looking for a motivated postdoctoral researcher with an interest in T cell development and single cell & spatial omics to join the team. We are a dynamic and international lab with a focus on the functional characterization of the molecular mechanisms that control human T cell development (Liang et al. Nat Immunol 2023, Lavaert et al. Immunity 2020; Roels et al. Nat Immunol 2020). As part of the Human Cell Atlas Thymus Seed Network, we have also been involved in high-resolution profiling of the developing human thymus using single cell multiomics and spatial transcriptomics (Yayon et al. Nature 2024, Park et al. Science 2020). Project
The thymus is a specialised organ that provides the necessary microenvironment to drive the development, maturation and selection of T lymphocytes from bone marrow-derived hematopoietic progenitor cells. Initially, these precursor cells have multi-lineage potential and can differentiate into various lymphoid and myeloid immune cell types in vitro, but it remains unclear which non-T lineages they can in fact give rise to within the physiological setting of the human thymus. The aim of the project is to investigate the potential development of alternative immune cell lineages within the fetal and postnatal thymus and to chart the role of the thymic microenvironment in this process. This will be achieved through the use of state-of-the-art technologies, such as multimodal single cell approaches (CITE-seq, scATAC-seq), spatial transcriptomics and high-throughput imaging, thus a keen interest in learning single cell/spatial data analysis is critical. Your profile
You hold a PhD in Biology, (Bio)medical Sciences, Biotechnology, Bioinformatics or equivalent. You have a proven scientific track record evidenced by relevant publications. You have experience in the computational analysis of single cell and/or transcriptomics data using R/Python. Wet lab experience is beneficial but not essential. You have a strong enthusiasm for fundamental research and a scientific interest in the molecular genetics of immune cell development. You are a team player with the ability to work independently. You have excellent communication and writing skills in scientific English. What we offer
An experienced team including lab technicians and a bioinformatician that will support your work. Expertise in thymus biology and single cell genomics. Possibility to follow training activities at UGent and abroad, support to attend (inter-)national research conferences. Support for independent fellowship applications and other career building activities. Possibility to initiate and lead independent projects within the group. Opportunities to connect with other leading labs in the field through ongoing collaborations. Full time contract with a highly competitive salary according to UGent salary scales. How to apply
For further information or to apply (include motivation letter, curriculum vitae and contact information of three potential referees), please contact Prof. Dr. Tom Taghon. Tom.Taghon@UGent.be
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Postdoctoral Position in molecular and computational immunology The research group of Prof Tom Taghon at Ghent University in Belgium is looking for a motivated postdoctoral researcher with an interest in T cell development and single cell & spatial omics to join the team. We are a dynamic and international lab with a focus on the functional characterization of the molecular mechanisms that control human T cell development (Liang et al. Nat Immunol 2023, Lavaert et al. Immunity 2020; Roels et al. Nat Immunol 2020). As part of the Human Cell Atlas Thymus Seed Network, we have also been involved in high-resolution profiling of the developing human thymus using single cell multiomics and spatial transcriptomics (Yayon et al. Nature 2024, Park et al. Science 2020). Project
The thymus is a specialised organ that provides the necessary microenvironment to drive the development, maturation and selection of T lymphocytes from bone marrow-derived hematopoietic progenitor cells. Initially, these precursor cells have multi-lineage potential and can differentiate into various lymphoid and myeloid immune cell types in vitro, but it remains unclear which non-T lineages they can in fact give rise to within the physiological setting of the human thymus. The aim of the project is to investigate the potential development of alternative immune cell lineages within the fetal and postnatal thymus and to chart the role of the thymic microenvironment in this process. This will be achieved through the use of state-of-the-art technologies, such as multimodal single cell approaches (CITE-seq, scATAC-seq), spatial transcriptomics and high-throughput imaging, thus a keen interest in learning single cell/spatial data analysis is critical. Your profile
You hold a PhD in Biology, (Bio)medical Sciences, Biotechnology, Bioinformatics or equivalent. You have a proven scientific track record evidenced by relevant publications. You have experience in the computational analysis of single cell and/or transcriptomics data using R/Python. Wet lab experience is beneficial but not essential. You have a strong enthusiasm for fundamental research and a scientific interest in the molecular genetics of immune cell development. You are a team player with the ability to work independently. You have excellent communication and writing skills in scientific English. What we offer
An experienced team including lab technicians and a bioinformatician that will support your work. Expertise in thymus biology and single cell genomics. Possibility to follow training activities at UGent and abroad, support to attend (inter-)national research conferences. Support for independent fellowship applications and other career building activities. Possibility to initiate and lead independent projects within the group. Opportunities to connect with other leading labs in the field through ongoing collaborations. Full time contract with a highly competitive salary according to UGent salary scales. How to apply
For further information or to apply (include motivation letter, curriculum vitae and contact information of three potential referees), please contact Prof. Dr. Tom Taghon. Tom.Taghon@UGent.be
#J-18808-Ljbffr