Madrigal Pharmaceuticals
Senior Director, Clinical Practice Liaisons
Madrigal Pharmaceuticals, Saint Louis, Missouri, United States, 63146
1 day ago Be among the first 25 applicants
Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH.
Madrigal’s medication, Rezdiffra (resmetirom), is a once‑daily, oral, liver‑directed THR‑β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).
Our success is driven by our people. We are building a dynamic, inclusive, and high‑performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way.
The Sr. Director, Clinical Practice Liaison (CPL) is a key field‑based leadership position responsible for the strategic and tactical oversight of the CPL team within a defined U.S. region. This individual will play a critical role in managing and developing CPLs, ensuring the team executes against the company’s medical strategy, complies with regulatory and internal policies, and delivers scientific value to both internal and external stakeholders.
This position will interface regularly and compliantly with cross‑functional colleagues (e.g., Marketing, Sales, Market Access, Clinical Operations, HQ Medical Affairs) and external partners, including Thought Leaders (TL), healthcare decision‑makers, and other relevant stakeholders.
Key Responsibilities
Team Leadership & Development
Recruit, coach, and manage performance of regional CPLs
Foster continuous development through mentoring and training
Align CPL activities with strategic objectives and tactical plans
Medical Strategy Execution
Drive implementation of regional field medical strategies
Translate national objectives into actionable, regionally tailored activities
Partner with cross‑functional teams to integrate field insights into medical planning
Cross‑functional Collaboration
Collaborate closely with Sales, Marketing, Market Access, and Clinical Operations
Serve as a field‑based liaison for HQ Medical Affairs initiatives
Contribute to launch readiness and lifecycle management strategies
Clinical Trial Support
Collaborate with Clinical Operations to ensure successful study execution based upon recognized needs
Congress & External Engagement
Represent Medical Affairs at U.S. medical congresses in a compliant manner
Coordinate booth planning, scientific exchange, competitive intelligence, and post‑conference debriefs
Strategic Team Building
Contribute to the design and structure of the U.S. Field Medical team
Identify evolving business needs and adjust regional capabilities accordingly
Compliance & Quality
Ensure all CPL activities comply with company SOPs, industry standards, and applicable regulations
Uphold the highest ethical standards in all external engagements
Travel Requirement
Willingness to travel 25–75% for congresses, site visits, and stakeholder engagement
Qualifications & Experience
Advanced degree in a scientific or healthcare discipline (MD, PharmD, PhD, DNP, etc.)
Minimum 5 years of Medical Affairs experience, including at least 3 years as an MSL or equivalent (translatable clinical practice experience will be considered)
Minimum 3 years of people management experience or formal leadership development participation
In-depth knowledge of clinical medicine and medical research; experience in cardiometabolic health, or MASH/NASH preferred
Proven ability to understand, communicate, and translate complex scientific information
Strong knowledge of U.S. healthcare system, FDA regulations, and medical affairs compliance standards
Demonstrated cross‑functional collaboration, project execution, and strategic planning skills
Proficiency in Microsoft Office Suite, virtual communication platforms (e.g., Zoom), and CRM systems (e.g., Veeva)
Preferred Attributes
Strong interpersonal, presentation, and relationship‑building skills
Adaptable and proactive in a fast‑paced, evolving environment
Passion for mentoring, team building, and field‑based medical innovation
Madrigal’s Total Rewards strategy is based on a biotech industry peer group comparator and is inclusive of base pay, bonus and equity. Our equity offers meaningful opportunity allowing our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization.
All full‑time employees receive equity, which we believe reinforces our ownership culture. Base salary is determined by several factors including the candidate’s qualifications, skills, education, experience, business needs and market demands. The base salary range for this position is $262,000 – $320,000 per year.
Full‑time employees are also eligible for comprehensive benefits, including flexible paid time off, medical, dental, vision and life/disability insurance, and 401(k) offerings (i.e., traditional, Roth, and employer match) in accordance with applicable plans. We also offer additional voluntary benefits like supplemental life insurance, legal services, and other offerings. In addition, we offer mental health benefits through our Employee Assistance Program for employees and their family. The company also provides other benefits in accordance with applicable federal, state, and local laws.
We are committed to providing reasonable accommodations for individuals with disabilities throughout the hiring process. If you need assistance, please contact HR@madrigalpharma.com.
Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications, merit, and business need. Applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex, gender identity, sexual orientation, national origin, age, disability, protected veteran or disabled status, or other characteristic protected by applicable federal, state, or local law.
Unsolicited resumes from agencies should not be forwarded to Madrigal. Madrigal will not be responsible for any fees arising from the use of resumes through this source. Madrigal will only pay a fee to agencies if a formal agreement between Madrigal and the agency has been established.
Applications are being accepted on an ongoing basis and can be submitted through our Madrigal Careers site.
Please be aware that we have received reports of individuals misrepresenting themselves as Madrigal Pharmaceuticals’ Hiring Managers, seeking to engage with job candidates through fraudulent online advertisements or job posting sites. These unauthorized individuals are using Madrigal’s name and logo in an attempt to solicit up‑front fees and obtain personal information from interested job candidates. Please know that Madrigal does not conduct interviews via text or in chat rooms; conduct interviews via Skype, RingCentral or solely via telephone; charge candidates an advance fee of any kind (e.g., fees for purchasing equipment); nor does it offer positions of employment without undergoing a thorough recruiting process.
Please also note that any correspondence with regard to employment would come from an authorized madrigalpharma.com email address or from an email address from one of our trusted search firm partners. We are aware that incorrect/fraudulent email addresses, with Madrigal misspelled, have been utilized in these most recent fraud attempts. If you receive unsolicited employment offers from people claiming to work for or on behalf of Madrigal, we recommend that: do not respond to their questions; do not open any attachments; and do not click on any hyperlinks. Any questions regarding the legitimacy of job‑related contacts can be directed to HR@madrigalpharma.com.
#J-18808-Ljbffr
Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH.
Madrigal’s medication, Rezdiffra (resmetirom), is a once‑daily, oral, liver‑directed THR‑β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).
Our success is driven by our people. We are building a dynamic, inclusive, and high‑performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way.
The Sr. Director, Clinical Practice Liaison (CPL) is a key field‑based leadership position responsible for the strategic and tactical oversight of the CPL team within a defined U.S. region. This individual will play a critical role in managing and developing CPLs, ensuring the team executes against the company’s medical strategy, complies with regulatory and internal policies, and delivers scientific value to both internal and external stakeholders.
This position will interface regularly and compliantly with cross‑functional colleagues (e.g., Marketing, Sales, Market Access, Clinical Operations, HQ Medical Affairs) and external partners, including Thought Leaders (TL), healthcare decision‑makers, and other relevant stakeholders.
Key Responsibilities
Team Leadership & Development
Recruit, coach, and manage performance of regional CPLs
Foster continuous development through mentoring and training
Align CPL activities with strategic objectives and tactical plans
Medical Strategy Execution
Drive implementation of regional field medical strategies
Translate national objectives into actionable, regionally tailored activities
Partner with cross‑functional teams to integrate field insights into medical planning
Cross‑functional Collaboration
Collaborate closely with Sales, Marketing, Market Access, and Clinical Operations
Serve as a field‑based liaison for HQ Medical Affairs initiatives
Contribute to launch readiness and lifecycle management strategies
Clinical Trial Support
Collaborate with Clinical Operations to ensure successful study execution based upon recognized needs
Congress & External Engagement
Represent Medical Affairs at U.S. medical congresses in a compliant manner
Coordinate booth planning, scientific exchange, competitive intelligence, and post‑conference debriefs
Strategic Team Building
Contribute to the design and structure of the U.S. Field Medical team
Identify evolving business needs and adjust regional capabilities accordingly
Compliance & Quality
Ensure all CPL activities comply with company SOPs, industry standards, and applicable regulations
Uphold the highest ethical standards in all external engagements
Travel Requirement
Willingness to travel 25–75% for congresses, site visits, and stakeholder engagement
Qualifications & Experience
Advanced degree in a scientific or healthcare discipline (MD, PharmD, PhD, DNP, etc.)
Minimum 5 years of Medical Affairs experience, including at least 3 years as an MSL or equivalent (translatable clinical practice experience will be considered)
Minimum 3 years of people management experience or formal leadership development participation
In-depth knowledge of clinical medicine and medical research; experience in cardiometabolic health, or MASH/NASH preferred
Proven ability to understand, communicate, and translate complex scientific information
Strong knowledge of U.S. healthcare system, FDA regulations, and medical affairs compliance standards
Demonstrated cross‑functional collaboration, project execution, and strategic planning skills
Proficiency in Microsoft Office Suite, virtual communication platforms (e.g., Zoom), and CRM systems (e.g., Veeva)
Preferred Attributes
Strong interpersonal, presentation, and relationship‑building skills
Adaptable and proactive in a fast‑paced, evolving environment
Passion for mentoring, team building, and field‑based medical innovation
Madrigal’s Total Rewards strategy is based on a biotech industry peer group comparator and is inclusive of base pay, bonus and equity. Our equity offers meaningful opportunity allowing our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization.
All full‑time employees receive equity, which we believe reinforces our ownership culture. Base salary is determined by several factors including the candidate’s qualifications, skills, education, experience, business needs and market demands. The base salary range for this position is $262,000 – $320,000 per year.
Full‑time employees are also eligible for comprehensive benefits, including flexible paid time off, medical, dental, vision and life/disability insurance, and 401(k) offerings (i.e., traditional, Roth, and employer match) in accordance with applicable plans. We also offer additional voluntary benefits like supplemental life insurance, legal services, and other offerings. In addition, we offer mental health benefits through our Employee Assistance Program for employees and their family. The company also provides other benefits in accordance with applicable federal, state, and local laws.
We are committed to providing reasonable accommodations for individuals with disabilities throughout the hiring process. If you need assistance, please contact HR@madrigalpharma.com.
Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications, merit, and business need. Applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex, gender identity, sexual orientation, national origin, age, disability, protected veteran or disabled status, or other characteristic protected by applicable federal, state, or local law.
Unsolicited resumes from agencies should not be forwarded to Madrigal. Madrigal will not be responsible for any fees arising from the use of resumes through this source. Madrigal will only pay a fee to agencies if a formal agreement between Madrigal and the agency has been established.
Applications are being accepted on an ongoing basis and can be submitted through our Madrigal Careers site.
Please be aware that we have received reports of individuals misrepresenting themselves as Madrigal Pharmaceuticals’ Hiring Managers, seeking to engage with job candidates through fraudulent online advertisements or job posting sites. These unauthorized individuals are using Madrigal’s name and logo in an attempt to solicit up‑front fees and obtain personal information from interested job candidates. Please know that Madrigal does not conduct interviews via text or in chat rooms; conduct interviews via Skype, RingCentral or solely via telephone; charge candidates an advance fee of any kind (e.g., fees for purchasing equipment); nor does it offer positions of employment without undergoing a thorough recruiting process.
Please also note that any correspondence with regard to employment would come from an authorized madrigalpharma.com email address or from an email address from one of our trusted search firm partners. We are aware that incorrect/fraudulent email addresses, with Madrigal misspelled, have been utilized in these most recent fraud attempts. If you receive unsolicited employment offers from people claiming to work for or on behalf of Madrigal, we recommend that: do not respond to their questions; do not open any attachments; and do not click on any hyperlinks. Any questions regarding the legitimacy of job‑related contacts can be directed to HR@madrigalpharma.com.
#J-18808-Ljbffr