Amylyx Pharmaceutical Corp.
Senior Director, Health Economics and Outcome Research/Real World Evidence
Amylyx Pharmaceutical Corp., Cambridge, Massachusetts, us, 02140
Senior Director, Health Economics and Outcome Research/Real World Evidence
Amylyx is a clinical-stage pharmaceutical company based in Cambridge, Massachusetts, focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, progressive supranuclear palsy (PSP), and amyotrophic lateral sclerosis (ALS). Our mission is powered by our people and core values: be audacious, be curious, be authentic, be engaged, and be accountable. We are committed to sincere engagement with the communities we serve and invite you to read the opportunity below and apply.
The Opportunity The Senior Director, Health Economics and Outcomes Research (HEOR)/Real World Evidence (RWE) at Amylyx Pharmaceuticals will report to the SVP of Medical Affairs. This role will be an expert and experienced leader, engaging cross-functionally to develop and drive HEOR and evidence generation strategies. The Senior Director will play an integral role in developing and communicating the value proposition for Amylyx assets, including our lead program in PBH. This role will drive development of strategies, methods, and tools to ensure successful market access, adoption, and long-term impact in support of Amylyx’ mission to find solutions for patients with high unmet needs.
Responsibilities
Strategic Leadership: Build and lead the HEOR function including the development of integrated HEOR and evidence generation strategies and tactical plans to support Amylyx’s therapeutic programs.
Lead evidence gap analyses that inform HEOR strategic and tactical plans and lead cross-functional data generation and communication planning to support health economic/value proposition and inform understanding of treatment patterns, disease burden, patient-reported outcomes, and unmet needs.
Evidence Generation & Study Execution: Design and execute projects such as burden of illness, real-world clinical outcomes, clinical registries, retrospective database analyses, and meta-analyses.
Provide scientific support for protocol development, target product profiles, data collection strategies, and literature review and evidence synthesis.
Stakeholder Engagement & Communication: Oversee the development of peer-reviewed publications, conference presentations, and internal communication of HEOR findings.
Support global market access strategy and plans for Amylyx pipeline products, including identifying opportunities for early scientific advice with key health technology assessment (HTA) agencies, regulatory support, and preparing for global HTA models. Incorporate recommendations into the clinical development program.
Cross-Functional Collaboration: Ensure HEOR tactics are aligned cross-functionally with business strategies and regulatory guidelines.
Monitor and interpret U.S. policy changes (e.g., IRA, CMS guidance) and translate implications into actionable HEOR strategies.
Collaborate with Market Access and Medical Affairs to develop and maintain evidence packages tailored to U.S. payers, including commercial plans, Medicare, and Medicaid.
Team & Vendor Management: Lead vendor selection and manage external research partners to ensure high-quality and timely study delivery. Build and manage a team to support innovative real-world evidence generation and health economics research. Manage HEOR budget planning and resource allocation.
Required Qualifications
10+ years healthcare or pharmaceutical industry experience with minimum 7 in HEOR
Master's Degree (MS, MPH, PharmD, PhD) in a relevant discipline (e.g., health economics, medicine, pharmacy, public health, epidemiology)
Demonstrated success in designing and leading real-world research to support US payer value and access
Experience supporting HEOR strategy for product launch, including pre-launch evidence generation and payer engagement
Deep understanding of U.S. healthcare system dynamics, including payer structures, value-based care, and regulatory trends
Excellent leadership and cross-functional collaboration skills with the ability to influence and drive strategy across teams and with external partners and vendors
Excellent analytical skills, including in-depth knowledge of COAs and pharmacoeconomic modeling and retrospective database analysis methodologies
Experience working with U.S. claims databases, EMRs, and patient registries; proficiency in RWE analytics platforms and methodologies
Knowledge of endocrine and/or obesity space a plus
Ability to travel up to 20%
Work Location and Conditions
Remote work opportunities within the United States are supported. We are unable to hire in certain states due to business considerations related to health insurance coverage and state tax regulations. Currently, we are not considering applicants from Alaska, Arizona, Hawaii, Michigan, and Tennessee.
You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary.
You must have access to a work setting that enables meeting all role requirements (privacy, reliable internet, phone, ability to video conference, etc.) at your remote location.
To stay connected with us follow Amylyx Pharmaceuticals on LinkedIn. To return to our website please click here.
Equal Opportunity Employer Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression, sexual orientation, marital status, military service and veteran status, disability, genetic information, or any other characteristic protected by applicable laws. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know.
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The Opportunity The Senior Director, Health Economics and Outcomes Research (HEOR)/Real World Evidence (RWE) at Amylyx Pharmaceuticals will report to the SVP of Medical Affairs. This role will be an expert and experienced leader, engaging cross-functionally to develop and drive HEOR and evidence generation strategies. The Senior Director will play an integral role in developing and communicating the value proposition for Amylyx assets, including our lead program in PBH. This role will drive development of strategies, methods, and tools to ensure successful market access, adoption, and long-term impact in support of Amylyx’ mission to find solutions for patients with high unmet needs.
Responsibilities
Strategic Leadership: Build and lead the HEOR function including the development of integrated HEOR and evidence generation strategies and tactical plans to support Amylyx’s therapeutic programs.
Lead evidence gap analyses that inform HEOR strategic and tactical plans and lead cross-functional data generation and communication planning to support health economic/value proposition and inform understanding of treatment patterns, disease burden, patient-reported outcomes, and unmet needs.
Evidence Generation & Study Execution: Design and execute projects such as burden of illness, real-world clinical outcomes, clinical registries, retrospective database analyses, and meta-analyses.
Provide scientific support for protocol development, target product profiles, data collection strategies, and literature review and evidence synthesis.
Stakeholder Engagement & Communication: Oversee the development of peer-reviewed publications, conference presentations, and internal communication of HEOR findings.
Support global market access strategy and plans for Amylyx pipeline products, including identifying opportunities for early scientific advice with key health technology assessment (HTA) agencies, regulatory support, and preparing for global HTA models. Incorporate recommendations into the clinical development program.
Cross-Functional Collaboration: Ensure HEOR tactics are aligned cross-functionally with business strategies and regulatory guidelines.
Monitor and interpret U.S. policy changes (e.g., IRA, CMS guidance) and translate implications into actionable HEOR strategies.
Collaborate with Market Access and Medical Affairs to develop and maintain evidence packages tailored to U.S. payers, including commercial plans, Medicare, and Medicaid.
Team & Vendor Management: Lead vendor selection and manage external research partners to ensure high-quality and timely study delivery. Build and manage a team to support innovative real-world evidence generation and health economics research. Manage HEOR budget planning and resource allocation.
Required Qualifications
10+ years healthcare or pharmaceutical industry experience with minimum 7 in HEOR
Master's Degree (MS, MPH, PharmD, PhD) in a relevant discipline (e.g., health economics, medicine, pharmacy, public health, epidemiology)
Demonstrated success in designing and leading real-world research to support US payer value and access
Experience supporting HEOR strategy for product launch, including pre-launch evidence generation and payer engagement
Deep understanding of U.S. healthcare system dynamics, including payer structures, value-based care, and regulatory trends
Excellent leadership and cross-functional collaboration skills with the ability to influence and drive strategy across teams and with external partners and vendors
Excellent analytical skills, including in-depth knowledge of COAs and pharmacoeconomic modeling and retrospective database analysis methodologies
Experience working with U.S. claims databases, EMRs, and patient registries; proficiency in RWE analytics platforms and methodologies
Knowledge of endocrine and/or obesity space a plus
Ability to travel up to 20%
Work Location and Conditions
Remote work opportunities within the United States are supported. We are unable to hire in certain states due to business considerations related to health insurance coverage and state tax regulations. Currently, we are not considering applicants from Alaska, Arizona, Hawaii, Michigan, and Tennessee.
You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary.
You must have access to a work setting that enables meeting all role requirements (privacy, reliable internet, phone, ability to video conference, etc.) at your remote location.
To stay connected with us follow Amylyx Pharmaceuticals on LinkedIn. To return to our website please click here.
Equal Opportunity Employer Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression, sexual orientation, marital status, military service and veteran status, disability, genetic information, or any other characteristic protected by applicable laws. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know.
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