BioSpace
Principal Research Scientist Late Stage Solid Form Development
BioSpace, Mettawa, Illinois, United States
Principal Research Scientist Late Stage Solid Form Development
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Principal Research Scientist Late Stage Solid Form Development
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BioSpace
Company Description AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. AbbVie strives to have a remarkable impact on people's lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, and products and services in the Allergan Aesthetics portfolio.
Job Description AbbVies Product Development Science & Technology (PDS&T) organization seeks a highly motivated, talented, and creative scientist with experience and expertise in solid state and materials characterization for a Principal Research Scientist I position. This person will make key contributions to late‑stage product development and commercialization, collaborating with cross‑functional teams to deliver robust isolation processes with well‑defined control strategies. An advanced degree in pharmaceutical sciences, chemistry, or chemical engineering and a strong understanding of crystallography, polymorphism, crystallization, isolation process, and materials characterization in the context of commercial product development are required.
Responsibilities
Independently plan, execute, and document experiments to characterize the solid‑state properties of regulatory starting materials and isolated intermediates following the selection of commercial synthetic routes, to develop robust control strategies.
Collaborate with solid‑state and materials scientists in R&D to identify and mitigate attributes of the drug substance that impact the performance characteristics of the drug product, ensuring robust drug substance control strategies.
Provide leadership within a matrixed team environment by serving as a subject‑matter expert (SME) in polymorphism, crystallography, and material attributes; collaborate with various cross‑functional stakeholders and support AbbVie manufacturing strategies.
Author and/or review technical reports, manufacturing batch records, and regulatory documents pertaining to Chemistry, Manufacturing, and Control (CMC) topics. Prepare and deliver concise scientific presentations and publications both within and outside of AbbVie.
Potentially mentor or supervise a team of one or more individuals, evaluate their performance, and be accountable for their effective performance. Build strong relationships and collaboratively drive activities with other functional units.
Generate new scientific proposals and lead these efforts. Anticipate and critically evaluate scientific or regulatory advances and competitive threats and respond with appropriate new strategies.
Ensure compliance with all applicable AbbVie policies and procedures.
Understand and adhere to corporate standards regarding code of conduct, safety, and GxP compliance.
Preferred Qualifications
Fundamental understanding of polymorphism, crystallography, crystallization, and materials characterization as they pertain to late‑stage product development and commercial manufacturing.
Experience with analytical methods for characterizing the solid‑state and material properties of synthetic molecules and excipients (e.g., DSC, TGA, PXRD, spectroscopy, etc.).
Familiarity with software platforms used for visualizing crystal structures and evaluating packing modes, particle shape, surface properties, and other related attributes.
Demonstrated scientific communication and presentation skills, with proven success as an author of publications, presentations, and/or as the primary inventor of patents.
Strong interpersonal and communication skills to facilitate collaborations, with a demonstrated ability to work within or lead cross‑functional process development teams.
Demonstrated creative, out‑of‑the‑box thinking to solve complex technical problems and champion new technologies to achieve project goals.
Qualifications
BS or equivalent education with typically 14+ years of experience; MS or equivalent education with typically 12+ years of experience; PhD with typically 6+ years of experience in a relevant scientific discipline.
Demonstrated ability to function as a principal investigator, generating original technical ideas and research or development strategies.
Demonstrated creative 'out‑of‑the‑box' thinking to solve difficult technical problems and champion new technologies to achieve project goals.
Recognized and sought out as an expert in their discipline within the company and possibly externally.
Experienced and demonstrated success as primary author of publications, presentations, regulatory documents and/or primary inventor of patents.
Demonstrated scientific communication and presentation skills by presenting at leading scientific conferences.
Benefits & Compensation
The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.
We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance, and 401(k) to eligible employees.
This job is eligible to participate in our short‑term incentive programs.
This job is eligible to participate in our long‑term incentive programs.
Equal Opportunity AbbVie is an equal‑opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer / Veterans / Disabled.
US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html
US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more: https://www.abbvie.com/join-us/reasonable-accommodations.html
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Principal Research Scientist Late Stage Solid Form Development
role at
BioSpace
Company Description AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. AbbVie strives to have a remarkable impact on people's lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, and products and services in the Allergan Aesthetics portfolio.
Job Description AbbVies Product Development Science & Technology (PDS&T) organization seeks a highly motivated, talented, and creative scientist with experience and expertise in solid state and materials characterization for a Principal Research Scientist I position. This person will make key contributions to late‑stage product development and commercialization, collaborating with cross‑functional teams to deliver robust isolation processes with well‑defined control strategies. An advanced degree in pharmaceutical sciences, chemistry, or chemical engineering and a strong understanding of crystallography, polymorphism, crystallization, isolation process, and materials characterization in the context of commercial product development are required.
Responsibilities
Independently plan, execute, and document experiments to characterize the solid‑state properties of regulatory starting materials and isolated intermediates following the selection of commercial synthetic routes, to develop robust control strategies.
Collaborate with solid‑state and materials scientists in R&D to identify and mitigate attributes of the drug substance that impact the performance characteristics of the drug product, ensuring robust drug substance control strategies.
Provide leadership within a matrixed team environment by serving as a subject‑matter expert (SME) in polymorphism, crystallography, and material attributes; collaborate with various cross‑functional stakeholders and support AbbVie manufacturing strategies.
Author and/or review technical reports, manufacturing batch records, and regulatory documents pertaining to Chemistry, Manufacturing, and Control (CMC) topics. Prepare and deliver concise scientific presentations and publications both within and outside of AbbVie.
Potentially mentor or supervise a team of one or more individuals, evaluate their performance, and be accountable for their effective performance. Build strong relationships and collaboratively drive activities with other functional units.
Generate new scientific proposals and lead these efforts. Anticipate and critically evaluate scientific or regulatory advances and competitive threats and respond with appropriate new strategies.
Ensure compliance with all applicable AbbVie policies and procedures.
Understand and adhere to corporate standards regarding code of conduct, safety, and GxP compliance.
Preferred Qualifications
Fundamental understanding of polymorphism, crystallography, crystallization, and materials characterization as they pertain to late‑stage product development and commercial manufacturing.
Experience with analytical methods for characterizing the solid‑state and material properties of synthetic molecules and excipients (e.g., DSC, TGA, PXRD, spectroscopy, etc.).
Familiarity with software platforms used for visualizing crystal structures and evaluating packing modes, particle shape, surface properties, and other related attributes.
Demonstrated scientific communication and presentation skills, with proven success as an author of publications, presentations, and/or as the primary inventor of patents.
Strong interpersonal and communication skills to facilitate collaborations, with a demonstrated ability to work within or lead cross‑functional process development teams.
Demonstrated creative, out‑of‑the‑box thinking to solve complex technical problems and champion new technologies to achieve project goals.
Qualifications
BS or equivalent education with typically 14+ years of experience; MS or equivalent education with typically 12+ years of experience; PhD with typically 6+ years of experience in a relevant scientific discipline.
Demonstrated ability to function as a principal investigator, generating original technical ideas and research or development strategies.
Demonstrated creative 'out‑of‑the‑box' thinking to solve difficult technical problems and champion new technologies to achieve project goals.
Recognized and sought out as an expert in their discipline within the company and possibly externally.
Experienced and demonstrated success as primary author of publications, presentations, regulatory documents and/or primary inventor of patents.
Demonstrated scientific communication and presentation skills by presenting at leading scientific conferences.
Benefits & Compensation
The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.
We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance, and 401(k) to eligible employees.
This job is eligible to participate in our short‑term incentive programs.
This job is eligible to participate in our long‑term incentive programs.
Equal Opportunity AbbVie is an equal‑opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer / Veterans / Disabled.
US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html
US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more: https://www.abbvie.com/join-us/reasonable-accommodations.html
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