Centessa Pharmaceuticals, LLC
Senior Director, Clinical Development
Centessa Pharmaceuticals, LLC, Boston, Massachusetts, us, 02298
Company Overview
Centessa Pharmaceuticals plc (Nasdaq: CNTA) is a pharmaceutical company with a deconstructed R&D environment that prioritizes data-driven decision making led by subject matter experts. Centessa is advancing a portfolio of high conviction programs with strong biological validation.
Centessa’s asset-centric model offers a unique R&D logic that has been applied by single asset companies to improve productivity. This operating model has minimal centralized infrastructure, reduced hierarchy, and exclusive focus on data-driven capital allocation. Our teams are uniquely incentivized to expeditiously interrogate key scientific hypotheses. We believe the asset-centric model can lead to improved success rates for programs with greater speed and modest costs.
Position Summary The Senior Director, Clinical Development will play a leadership role in Centessa’s development of sleep-wake disorders and other CNS indications. Reporting to the Senior Vice President, Clinical Development, this individual will work closely with cross-functional team members to execute all activities associated with study conduct and interpretation of data from clinical trials. This individual will engage key external partners in the medical and scientific community and will provide medical expertise to support regulatory submissions and interactions with global regulatory authorities. This highly visible role will impact and help shape the direction and success of the company.
Key Responsibilities
Author clinical study protocols for orexin agonists.
Provide scientific and medical expertise to effectively execute clinical studies and advance accelerated development programs.
Contribute to develop the design of a cross-functionally aligned clinical development plan to advance multiple orexin agonist candidate molecules.
Collaborate with clinical operations to meet timeline, cost and quality performance expectations and achieve program milestones.
Provide medical insight and leadership in the design of translational medicine approaches exploring indication expansion opportunities.
Effectively communicate and collaborate across internal disciplines and with key external partners, experts and investigators to position orexin agonist programs at the forefront of research and development for new medicines in sleep disorders.
Provide oversight of study integrity and timelines, and communication of information pertaining to safety and efficacy of clinical candidate molecules.
Author and review clinical sections of regulatory documents, clinical study reports, scientific publications, presentations, and other program documents.
Ensure adherence to Good Clinical Practices, pharmacovigilance standards, standard operating procedures and quality standards in conducting clinical research.
Qualifications
MD in neurology or psychiatry (board certification preferred).
Clinical and/or academic experience in neurological disorders; 5 years of pharmaceutical industry experience.
Translational medicine expertise highly desired.
Experience in early clinical development through late stage with successful design and implementation of proof-of-concept studies; submission experience in the neuroscience area desired.
Knowledge of US and EU regulatory guidelines and experience in interactions with regulatory agencies.
Outstanding written and verbal communication, with a passion for problem solving and effective cross-functional stakeholder engagement.
Ability to work independently and thrive in a fast-paced dynamic matrix environment.
An entrepreneurial spirit with high degree of energy and personal accountability.
Compensation and Benefits The annual base salary range for this position is $235,000 to $310,000. Individual compensation within this range will be determined based on a variety of factors, including qualifications, skills, relevant experience, and job knowledge.
In addition to base pay, this role is eligible for a discretionary annual bonus and participation in our equity program, allowing you to share in Centessa’s long-term success.
Centessa offers a comprehensive benefits package, which includes a 401(k) plan, company-sponsored medical, dental, vision and life insurance, generous paid time off, and a health and wellness program.
Work Location The Senior Director, Clinical Development is a remote role based in the US, with approximately 15% travel.
Position and Employment Full-Time, Exempt.
EEOC Statement Centessa Pharmaceuticals believes in a diverse environment and is committed to equal employment opportunity for all employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion, or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Centessa Pharmaceuticals will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
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Centessa’s asset-centric model offers a unique R&D logic that has been applied by single asset companies to improve productivity. This operating model has minimal centralized infrastructure, reduced hierarchy, and exclusive focus on data-driven capital allocation. Our teams are uniquely incentivized to expeditiously interrogate key scientific hypotheses. We believe the asset-centric model can lead to improved success rates for programs with greater speed and modest costs.
Position Summary The Senior Director, Clinical Development will play a leadership role in Centessa’s development of sleep-wake disorders and other CNS indications. Reporting to the Senior Vice President, Clinical Development, this individual will work closely with cross-functional team members to execute all activities associated with study conduct and interpretation of data from clinical trials. This individual will engage key external partners in the medical and scientific community and will provide medical expertise to support regulatory submissions and interactions with global regulatory authorities. This highly visible role will impact and help shape the direction and success of the company.
Key Responsibilities
Author clinical study protocols for orexin agonists.
Provide scientific and medical expertise to effectively execute clinical studies and advance accelerated development programs.
Contribute to develop the design of a cross-functionally aligned clinical development plan to advance multiple orexin agonist candidate molecules.
Collaborate with clinical operations to meet timeline, cost and quality performance expectations and achieve program milestones.
Provide medical insight and leadership in the design of translational medicine approaches exploring indication expansion opportunities.
Effectively communicate and collaborate across internal disciplines and with key external partners, experts and investigators to position orexin agonist programs at the forefront of research and development for new medicines in sleep disorders.
Provide oversight of study integrity and timelines, and communication of information pertaining to safety and efficacy of clinical candidate molecules.
Author and review clinical sections of regulatory documents, clinical study reports, scientific publications, presentations, and other program documents.
Ensure adherence to Good Clinical Practices, pharmacovigilance standards, standard operating procedures and quality standards in conducting clinical research.
Qualifications
MD in neurology or psychiatry (board certification preferred).
Clinical and/or academic experience in neurological disorders; 5 years of pharmaceutical industry experience.
Translational medicine expertise highly desired.
Experience in early clinical development through late stage with successful design and implementation of proof-of-concept studies; submission experience in the neuroscience area desired.
Knowledge of US and EU regulatory guidelines and experience in interactions with regulatory agencies.
Outstanding written and verbal communication, with a passion for problem solving and effective cross-functional stakeholder engagement.
Ability to work independently and thrive in a fast-paced dynamic matrix environment.
An entrepreneurial spirit with high degree of energy and personal accountability.
Compensation and Benefits The annual base salary range for this position is $235,000 to $310,000. Individual compensation within this range will be determined based on a variety of factors, including qualifications, skills, relevant experience, and job knowledge.
In addition to base pay, this role is eligible for a discretionary annual bonus and participation in our equity program, allowing you to share in Centessa’s long-term success.
Centessa offers a comprehensive benefits package, which includes a 401(k) plan, company-sponsored medical, dental, vision and life insurance, generous paid time off, and a health and wellness program.
Work Location The Senior Director, Clinical Development is a remote role based in the US, with approximately 15% travel.
Position and Employment Full-Time, Exempt.
EEOC Statement Centessa Pharmaceuticals believes in a diverse environment and is committed to equal employment opportunity for all employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion, or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Centessa Pharmaceuticals will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
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