MedTech Innovator
Scientist, Biopolymer Chemistry
MedTech Innovator, Berkeley, California, United States, 94709
About Glyphic:
At Glyphic Biotechnologies, we plan to create the protein revolution for which scientists and researchers have been waiting. We are developing a massively parallel, single-molecule proteome sequencing platform that will transform life science discovery and usher in a new era of insights into human biology and disease. To date, we have raised >$50M from venture partners and non-dilutive grant funding to achieve our vision of next generation proteome sequencing.
What we are looking for in you
Glyphic is seeking a highly motivated Scientist to join the Chemistry Department to assist in the advancement of our cutting‑edge single molecule proteome sequencing platform.
The ideal candidate will have a strong background in peptide chemistry, bioconjugation, analytical instrumentation, and be eager to contribute to transformative advances in proteomics. The scientist will work with a cross‑disciplinary team of scientists, engineers, and bioinformatics experts to rapidly deliver consistent results and insights that accelerate the development cycle.
What you’ll do
Design, develop, and optimize high throughput chemical reagent evaluation for single molecule protein sequencing, ensuring high sensitivity, specificity, and reproducibility
Synthesize assay specific reagents and materials for the proteome sequencing platform
Develop and/or validate peptide sample preparation schemes, such as C‑terminal conjugation and amino acid side‑chain derivatization
Collaborate with cross‑functional teams to problem solve and integrate novel solutions into the assay workflow
Analyze complex experimental data, generate detailed reports, and provide actionable insights to guide further development
Utilize statistical methods and data visualization tools to interpret assay performance and ensure rigorous quality control
Prepare and maintain comprehensive documentation of experimental protocols, standard operating procedures (SOPs), and results
Drive innovation in reagent and compound synthesis and design and contribute to intellectual property development
What you need
Required:
Degree in chemistry, organic chemistry, or related field. Advanced degree preferred.
0+ years (PhD), 2+ years (MS), 4+ years (B.S.) of industry or equivalent experience in peptide chemistry
Hands‑on development, optimization, and troubleshooting of solid‑phase peptide synthesis (SPPS) protocols.
Experience developing methods for one or more of the following:
advanced orthogonal protecting group strategies (beyond Fmoc/Boc)
site‑specific amino acid chemistry
segment coupling methods akin to native chemical ligation and C‑terminal thioester intermediates; and/or
selective on‑resin modification of aromatic sidechains (Trp, Tyr) for fluorophore labeling
Proven experience with bioconjugation and biorthogonal conjugation methods
Analytical experience with HPLC, LC/MS, NMR, FTIR, UV/VIS, CE
Experience in data analysis software
Experience in statistical and DOE software
Nice to have:
C‑terminal conjugation, and modification of amino acid sidechains beyond cysteine and lysine.
Experience with nucleic acid synthesis, natural and modified analogs
Knowledgeable about protein purification and fractionation from complex sample matrices
Proficiency in scalable surface chemistry methods and techniques for flow cells and/or solid supports
Experience in an industrial or startup setting
Experience in the development of commercial products
We’re looking for teammates with:
Excellent interpersonal skills – capable of building strong relationships and communicating effectively with stakeholders at all levels.
High emotional and analytical intelligence – able to navigate complex team dynamics, partnerships, and challenges with creativity and logic.
Resourceful adaptability – operates with urgency, remains flexible in evolving environments, and thrives in ambiguity.
Collaborative spirit – enjoys working across disciplines and explaining complex concepts to diverse audiences.
What you can expect
Work environment:
Collaborative full‑time in‑person work at our Berkeley office
Access to cutting‑edge technology in a top tier life science facility
Collaborative culture where your ideas and expertise are valued
Direct impact on product development and company direction
Professional growth:
Learn from a diverse team of world‑class scientists and engineers
Contribute to first‑of‑their kind technologies, high‑impact publications, and patents
Compensation
Estimated Base Salary $109,000 - $144,000
This is the pay range for this position that we reasonably expect to pay. Individual compensation is based on various factors including, experience, education, skillset, and geographic location. This range is for the SF Bay Area, California location and may be adjusted to the labor market in other geographic areas.
Benefits and Perks:
Employee Stock Option Plan
100% Health Plan Coverage for Employees & Dependents (Medical, Dental, & Vision)
Employer Retirement Contributions to 401(k)
Generous Paid Time Off
Paid Maternity and Paternity Leave
Health & Wellbeing Program
Office Snacks and Beverages
Regular Team Bonding Activities
We are an Equal Opportunity Employer. We celebrate diversity and are committed to creating an inclusive environment for all employees. Individuals seeking employment at Glyphic Biotechnologies are considered without regard to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation.
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What we are looking for in you
Glyphic is seeking a highly motivated Scientist to join the Chemistry Department to assist in the advancement of our cutting‑edge single molecule proteome sequencing platform.
The ideal candidate will have a strong background in peptide chemistry, bioconjugation, analytical instrumentation, and be eager to contribute to transformative advances in proteomics. The scientist will work with a cross‑disciplinary team of scientists, engineers, and bioinformatics experts to rapidly deliver consistent results and insights that accelerate the development cycle.
What you’ll do
Design, develop, and optimize high throughput chemical reagent evaluation for single molecule protein sequencing, ensuring high sensitivity, specificity, and reproducibility
Synthesize assay specific reagents and materials for the proteome sequencing platform
Develop and/or validate peptide sample preparation schemes, such as C‑terminal conjugation and amino acid side‑chain derivatization
Collaborate with cross‑functional teams to problem solve and integrate novel solutions into the assay workflow
Analyze complex experimental data, generate detailed reports, and provide actionable insights to guide further development
Utilize statistical methods and data visualization tools to interpret assay performance and ensure rigorous quality control
Prepare and maintain comprehensive documentation of experimental protocols, standard operating procedures (SOPs), and results
Drive innovation in reagent and compound synthesis and design and contribute to intellectual property development
What you need
Required:
Degree in chemistry, organic chemistry, or related field. Advanced degree preferred.
0+ years (PhD), 2+ years (MS), 4+ years (B.S.) of industry or equivalent experience in peptide chemistry
Hands‑on development, optimization, and troubleshooting of solid‑phase peptide synthesis (SPPS) protocols.
Experience developing methods for one or more of the following:
advanced orthogonal protecting group strategies (beyond Fmoc/Boc)
site‑specific amino acid chemistry
segment coupling methods akin to native chemical ligation and C‑terminal thioester intermediates; and/or
selective on‑resin modification of aromatic sidechains (Trp, Tyr) for fluorophore labeling
Proven experience with bioconjugation and biorthogonal conjugation methods
Analytical experience with HPLC, LC/MS, NMR, FTIR, UV/VIS, CE
Experience in data analysis software
Experience in statistical and DOE software
Nice to have:
C‑terminal conjugation, and modification of amino acid sidechains beyond cysteine and lysine.
Experience with nucleic acid synthesis, natural and modified analogs
Knowledgeable about protein purification and fractionation from complex sample matrices
Proficiency in scalable surface chemistry methods and techniques for flow cells and/or solid supports
Experience in an industrial or startup setting
Experience in the development of commercial products
We’re looking for teammates with:
Excellent interpersonal skills – capable of building strong relationships and communicating effectively with stakeholders at all levels.
High emotional and analytical intelligence – able to navigate complex team dynamics, partnerships, and challenges with creativity and logic.
Resourceful adaptability – operates with urgency, remains flexible in evolving environments, and thrives in ambiguity.
Collaborative spirit – enjoys working across disciplines and explaining complex concepts to diverse audiences.
What you can expect
Work environment:
Collaborative full‑time in‑person work at our Berkeley office
Access to cutting‑edge technology in a top tier life science facility
Collaborative culture where your ideas and expertise are valued
Direct impact on product development and company direction
Professional growth:
Learn from a diverse team of world‑class scientists and engineers
Contribute to first‑of‑their kind technologies, high‑impact publications, and patents
Compensation
Estimated Base Salary $109,000 - $144,000
This is the pay range for this position that we reasonably expect to pay. Individual compensation is based on various factors including, experience, education, skillset, and geographic location. This range is for the SF Bay Area, California location and may be adjusted to the labor market in other geographic areas.
Benefits and Perks:
Employee Stock Option Plan
100% Health Plan Coverage for Employees & Dependents (Medical, Dental, & Vision)
Employer Retirement Contributions to 401(k)
Generous Paid Time Off
Paid Maternity and Paternity Leave
Health & Wellbeing Program
Office Snacks and Beverages
Regular Team Bonding Activities
We are an Equal Opportunity Employer. We celebrate diversity and are committed to creating an inclusive environment for all employees. Individuals seeking employment at Glyphic Biotechnologies are considered without regard to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation.
#J-18808-Ljbffr