BioSpace
Senior Scientist, Protein Analytical Characterization
BioSpace, Worcester, Massachusetts, us, 01609
Senior Scientist, Protein Analytical Characterization
Company Description
AbbVie’s mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address future medical challenges. We strive to have a remarkable impact on people’s lives across key therapeutic areas—immunology, oncology, neuroscience, and eye care—while providing products and services in our Allergan Aesthetics portfolio. Job Description
Discovery Biotherapeutics and Genetic Medicine (BGM) at AbbVie is seeking a highly motivated and experienced scientist to join the Protein Sciences Analytical Team in Worcester, MA. This position provides a unique opportunity to directly impact multiple Discovery Research Therapeutic Areas (TAs) and projects by delivering in‑depth analytical and functional characterization of biologics and biopharmaceutical products, including complex protein antigens, monoclonal antibodies, multi‑specifics, and other antibody‑like biologics. Key Responsibilities
Independently develop and execute high‑throughput HDX‑MS workflows for epitope mapping analysis of biotherapeutics to support the discovery pipeline. Develop, optimize, validate, and apply innovative structural MS methods (including XL‑MS and CL‑MS) to characterize epitopes and antigen‑antibody interactions. Demonstrate scientific initiative by establishing novel workflows and strategies for the characterization and screening of biologics—including non‑traditional modalities such as multi‑specifics, alternative scaffolds, and fusion proteins—to support BGM and TA projects. Collaborate with external partners, CROs, or vendors to advance project objectives. Analyze, document, and report data concisely; formulate conclusions and design follow‑on experiments based on multidisciplinary inputs. Resolve key project challenges by leveraging analytical tools, information, and technical expertise. Communicate project progress, data analyses, and technical recommendations clearly and promptly to cross‑functional teams and senior management. Present original research and findings internally and at external scientific conferences; contribute to scientific papers, patents, and technical reports as an author or co‑author. Qualifications
BS, MS, or PhD in biology, chemistry, biochemistry, or related field with typical experience ranges (10‑12+ years for BS; 8‑10+ years for MS; 0‑4+ years for PhD). Extensive hands‑on experience with HDX‑MS platforms (e.g., Trajan LEAP HDX automation) and use of HDX‑MS data analysis software (e.g., HDExaminer) for epitope mapping analysis. Strong knowledge of structural mass spectrometry technologies, including covalent labeling MS and crosslinking MS. Advanced proficiency with multiple mass spectrometry platforms (e.g., Orbitrap and Q‑ToF), including MS workflows for protein characterization and expertise with relevant data analysis software. Familiarity or experience with coding/programming (e.g., Python, R, or relevant scripting languages) and developing automated data workflows or solutions is preferred. Familiarity with biophysical and structural methods (e.g., DLS, DSF, SEC‑MALS, SEC‑SAX, X‑ray crystallography) is a plus. Demonstrated theoretical and hands‑on expertise in scientific disciplines, with a proven ability to rapidly learn and apply new technologies. Excellent organizational skills and ability to manage multiple projects and tasks concurrently while meeting deadlines. Collaborative, goal‑driven professional with strong verbal and written communication skills, a proactive attitude, and success operating in fast‑paced, cross‑functional environments. Key AbbVie Competencies
Builds strong relationships with peers and cross‑functionally with partners outside of the team to enable high performance. Learns fast, grasps the essence and can change course quickly when indicated. Raises the bar and is never satisfied with the status quo. Creates a learning environment, open to suggestions and experimentation for improvement. Embraces the ideas of others, nurtures innovation and manages innovation to reality. Compensation and Benefits
The compensation range described below is the range of possible base pay compensation that the company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors, including geographic location; the company may ultimately pay more or less than the posted range, and this range may be modified in the future. We offer a comprehensive package of benefits, including paid time off (vacation, holidays, sick), medical/dental/vision insurance, and 401(k) to eligible employees. This job is eligible to participate in our short‑term incentive programs and may be eligible for long‑term incentive programs. Equal Opportunity Statement
AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives, and serving our community. Equal Opportunity Employer, Veterans, Disabled. US & Puerto Rico only – to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html US & Puerto Rico applicants seeking a reasonable accommodation, visit https://www.abbvie.com/join-us/reasonable-accommodations.html
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Company Description
AbbVie’s mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address future medical challenges. We strive to have a remarkable impact on people’s lives across key therapeutic areas—immunology, oncology, neuroscience, and eye care—while providing products and services in our Allergan Aesthetics portfolio. Job Description
Discovery Biotherapeutics and Genetic Medicine (BGM) at AbbVie is seeking a highly motivated and experienced scientist to join the Protein Sciences Analytical Team in Worcester, MA. This position provides a unique opportunity to directly impact multiple Discovery Research Therapeutic Areas (TAs) and projects by delivering in‑depth analytical and functional characterization of biologics and biopharmaceutical products, including complex protein antigens, monoclonal antibodies, multi‑specifics, and other antibody‑like biologics. Key Responsibilities
Independently develop and execute high‑throughput HDX‑MS workflows for epitope mapping analysis of biotherapeutics to support the discovery pipeline. Develop, optimize, validate, and apply innovative structural MS methods (including XL‑MS and CL‑MS) to characterize epitopes and antigen‑antibody interactions. Demonstrate scientific initiative by establishing novel workflows and strategies for the characterization and screening of biologics—including non‑traditional modalities such as multi‑specifics, alternative scaffolds, and fusion proteins—to support BGM and TA projects. Collaborate with external partners, CROs, or vendors to advance project objectives. Analyze, document, and report data concisely; formulate conclusions and design follow‑on experiments based on multidisciplinary inputs. Resolve key project challenges by leveraging analytical tools, information, and technical expertise. Communicate project progress, data analyses, and technical recommendations clearly and promptly to cross‑functional teams and senior management. Present original research and findings internally and at external scientific conferences; contribute to scientific papers, patents, and technical reports as an author or co‑author. Qualifications
BS, MS, or PhD in biology, chemistry, biochemistry, or related field with typical experience ranges (10‑12+ years for BS; 8‑10+ years for MS; 0‑4+ years for PhD). Extensive hands‑on experience with HDX‑MS platforms (e.g., Trajan LEAP HDX automation) and use of HDX‑MS data analysis software (e.g., HDExaminer) for epitope mapping analysis. Strong knowledge of structural mass spectrometry technologies, including covalent labeling MS and crosslinking MS. Advanced proficiency with multiple mass spectrometry platforms (e.g., Orbitrap and Q‑ToF), including MS workflows for protein characterization and expertise with relevant data analysis software. Familiarity or experience with coding/programming (e.g., Python, R, or relevant scripting languages) and developing automated data workflows or solutions is preferred. Familiarity with biophysical and structural methods (e.g., DLS, DSF, SEC‑MALS, SEC‑SAX, X‑ray crystallography) is a plus. Demonstrated theoretical and hands‑on expertise in scientific disciplines, with a proven ability to rapidly learn and apply new technologies. Excellent organizational skills and ability to manage multiple projects and tasks concurrently while meeting deadlines. Collaborative, goal‑driven professional with strong verbal and written communication skills, a proactive attitude, and success operating in fast‑paced, cross‑functional environments. Key AbbVie Competencies
Builds strong relationships with peers and cross‑functionally with partners outside of the team to enable high performance. Learns fast, grasps the essence and can change course quickly when indicated. Raises the bar and is never satisfied with the status quo. Creates a learning environment, open to suggestions and experimentation for improvement. Embraces the ideas of others, nurtures innovation and manages innovation to reality. Compensation and Benefits
The compensation range described below is the range of possible base pay compensation that the company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors, including geographic location; the company may ultimately pay more or less than the posted range, and this range may be modified in the future. We offer a comprehensive package of benefits, including paid time off (vacation, holidays, sick), medical/dental/vision insurance, and 401(k) to eligible employees. This job is eligible to participate in our short‑term incentive programs and may be eligible for long‑term incentive programs. Equal Opportunity Statement
AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives, and serving our community. Equal Opportunity Employer, Veterans, Disabled. US & Puerto Rico only – to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html US & Puerto Rico applicants seeking a reasonable accommodation, visit https://www.abbvie.com/join-us/reasonable-accommodations.html
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