Vor Bio
J oin Us in Tackling Autoimmune Disease at Its Root
At Vor, we believe science can do more than manage symptoms. It can change the course of disease. By advancing telitacicept, a first‑and potentially best‑in‑class dual BA/APRIL inhibitor, we are silencing upstream survival signals and stopping downstream autoimmune cascades. Together, we are addressing disease at its root cause and rewriting what is possible for patients worldwide.
When you join Vor, you’re not just working on a medicine. You’re part of a mission redefine the future of autoimmune care.
Impact: Contribute directly to a medicine with best‑in‑disease Phase 3 results in myasthenia gravis and expansion into multiple autoimmune diseases.
Growth: Be part of a rapidly scaling company with opportunities to grow your career in science, clinical development, commercial strategy, and beyond.
Innovation: Work on a platform with potential beyond one indication — a therapy that has already shown consistent results across lupus, IgA nephropathy, and Sjögren’s syndrome.
Belonging: Join a culture where every voice is heard, and where our shared mission unites us across functions and geographies.
The Senior Data Manager is responsible for all data management activities from study start‑up through database lock and archiving and independently supporting the needs of the clinical study and programs of studies. The Senior Data Manager will ensure completeness, accuracy and consistency and meet the standards of quality analysis and reporting to regulatory bodies. In addition, the Senior Data Manager has an active role in continuous improvement and acts as a leader in the department as demonstrated by successful mentoring and consistent study delivery over time.
Responsibilities
Serves as data lead for one or more clinical trials, assuming responsibility for all data management activities, including access levels and permissioning
Conduct oversight of data management activities performed by the CROs and other 3rd party vendors (IRT, Safety, Lab, etc.) to meet Lexeo obligations and business objectives throughout study life cycle i.e. from protocol synopsis through database release and submission
Ensure the CRO and other internal and external partners align and conform to data management expectations for the assigned compound and/or indication
Participate in the creation of the clinical development plan, describing the clinical development strategy and possible innovative trial designs
Proactively drive quality and efficiency set quality expectations and timelines for data management deliverables and regularly follow up on data management milestones. Ensure inspection readiness at all times
Set expectations and communicate a transparent, clear way and motive team members to work towards achieving the clinical goals
Follow department and company standard operating procedures (SOPs), forms, templates and policies. Provide feedback and update these guidelines as needed
Develop, review, and maintain all study Data Management documentation
Coordinate with Database Developers to ensure effective database build and timely go‑live to meet the needs of the project
Ensure the clinical database adheres to Clinical Data Acquisition Harmonization guidelines allowing for optimal SDTM dataset programming. Suggest design for standard and non‑standard data collection, identify any gaps in data collection, and challenge collection of unnecessary data
Plan, perform and oversee development of specifications for eCRFs, edit checks, electronic data handling, manual review, and execution of User Acceptance Testing in collaboration with CROs and relevant functional partners. Define electronic case report form (eCRF) and edit check specifications to support data collection and analysis required per protocol
Manage end‑to‑end delivery of data management services for assigned projects/studies, collaborating with CROs and other vendors to ensure deliverables are on time and of high quality
Work with the CRO to ensure all data cleaning tools are in place for EDC, IRT, SAE and all external data sources to ensure consistency, accuracy, and integrity of clinical data. Take responsibility for and guide effective quality control (QC) review and user acceptance testing (UAT) of the clinical database prior to its release into production, including oversight of staff performing these tasks
Ensure data are properly reviewed in accordance with the Data Management Plan (DMP) and guidelines and that cleaning is effective and timely
Provide input on study timelines, identify risks, and communicate mitigation strategies to the Project Manager
Provide input into improving the efficiency of data management tasks
Lead and participate in intradepartmental or interdepartmental process and quality improvement initiatives
Requirements
Bachelor's Degree in programming, health‑related sciences, or relevant field and 7+ years of Data Management experience
In depth knowledge of industry leading eCRF tools and well versed in industry trends and emerging technologies supporting data collection
Knowledge of clinical research, FDA & ICH, GCP, GCDMP, related regulatory requirements
Proven direct experience with data management tasks as well as DM vendor oversight to meet aggressive timelines of high‑quality data deliverables
Analytical and problem‑solving capabilities
Excellent verbal and written communication skills
Professional interpersonal skills
Ability to work well with a multi‑disciplinary team of professionals
Flexible attitude with respect to work assignments and new learning
Ability to prioritize workload
Superior attention to detail
Understanding of clinical research and the relationship of Data Management in the clinical study process
Strong technical aptitude and ability to adapt to multiple data management platforms
Strong knowledge of electronic data capture (EDC) clinical data management systems
Strong computer skills (Microsoft Office Suite, Medidata Rave) and ability to understand and adapt to various information technology (IT) systems
The salary range for the Senior Data Manager is expected to be between $175,000 and $190,000 per year. Individual pay may vary based on multiple factors including but not limited to relevant job‑related skills, experience, education or training, market factors, and work location.
At Vor, we support our team with robust benefits, including comprehensive health coverage, flexible paid time off, generous parental leave, and a competitive 401(k). From education assistance to wellness resources and financial security, we invest in your well‑being so you can thrive at work and beyond.
As an equal opportunity employer, we at Vor Bio know that diversity inspires innovation, inclusiveness, and creativity. We invite you to come as you are. All applicants will be considered for employment agnostic to race, age, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.
Please visit our website at https://www.vorbio.com/ for more information.
#J-18808-Ljbffr
At Vor, we believe science can do more than manage symptoms. It can change the course of disease. By advancing telitacicept, a first‑and potentially best‑in‑class dual BA/APRIL inhibitor, we are silencing upstream survival signals and stopping downstream autoimmune cascades. Together, we are addressing disease at its root cause and rewriting what is possible for patients worldwide.
When you join Vor, you’re not just working on a medicine. You’re part of a mission redefine the future of autoimmune care.
Impact: Contribute directly to a medicine with best‑in‑disease Phase 3 results in myasthenia gravis and expansion into multiple autoimmune diseases.
Growth: Be part of a rapidly scaling company with opportunities to grow your career in science, clinical development, commercial strategy, and beyond.
Innovation: Work on a platform with potential beyond one indication — a therapy that has already shown consistent results across lupus, IgA nephropathy, and Sjögren’s syndrome.
Belonging: Join a culture where every voice is heard, and where our shared mission unites us across functions and geographies.
The Senior Data Manager is responsible for all data management activities from study start‑up through database lock and archiving and independently supporting the needs of the clinical study and programs of studies. The Senior Data Manager will ensure completeness, accuracy and consistency and meet the standards of quality analysis and reporting to regulatory bodies. In addition, the Senior Data Manager has an active role in continuous improvement and acts as a leader in the department as demonstrated by successful mentoring and consistent study delivery over time.
Responsibilities
Serves as data lead for one or more clinical trials, assuming responsibility for all data management activities, including access levels and permissioning
Conduct oversight of data management activities performed by the CROs and other 3rd party vendors (IRT, Safety, Lab, etc.) to meet Lexeo obligations and business objectives throughout study life cycle i.e. from protocol synopsis through database release and submission
Ensure the CRO and other internal and external partners align and conform to data management expectations for the assigned compound and/or indication
Participate in the creation of the clinical development plan, describing the clinical development strategy and possible innovative trial designs
Proactively drive quality and efficiency set quality expectations and timelines for data management deliverables and regularly follow up on data management milestones. Ensure inspection readiness at all times
Set expectations and communicate a transparent, clear way and motive team members to work towards achieving the clinical goals
Follow department and company standard operating procedures (SOPs), forms, templates and policies. Provide feedback and update these guidelines as needed
Develop, review, and maintain all study Data Management documentation
Coordinate with Database Developers to ensure effective database build and timely go‑live to meet the needs of the project
Ensure the clinical database adheres to Clinical Data Acquisition Harmonization guidelines allowing for optimal SDTM dataset programming. Suggest design for standard and non‑standard data collection, identify any gaps in data collection, and challenge collection of unnecessary data
Plan, perform and oversee development of specifications for eCRFs, edit checks, electronic data handling, manual review, and execution of User Acceptance Testing in collaboration with CROs and relevant functional partners. Define electronic case report form (eCRF) and edit check specifications to support data collection and analysis required per protocol
Manage end‑to‑end delivery of data management services for assigned projects/studies, collaborating with CROs and other vendors to ensure deliverables are on time and of high quality
Work with the CRO to ensure all data cleaning tools are in place for EDC, IRT, SAE and all external data sources to ensure consistency, accuracy, and integrity of clinical data. Take responsibility for and guide effective quality control (QC) review and user acceptance testing (UAT) of the clinical database prior to its release into production, including oversight of staff performing these tasks
Ensure data are properly reviewed in accordance with the Data Management Plan (DMP) and guidelines and that cleaning is effective and timely
Provide input on study timelines, identify risks, and communicate mitigation strategies to the Project Manager
Provide input into improving the efficiency of data management tasks
Lead and participate in intradepartmental or interdepartmental process and quality improvement initiatives
Requirements
Bachelor's Degree in programming, health‑related sciences, or relevant field and 7+ years of Data Management experience
In depth knowledge of industry leading eCRF tools and well versed in industry trends and emerging technologies supporting data collection
Knowledge of clinical research, FDA & ICH, GCP, GCDMP, related regulatory requirements
Proven direct experience with data management tasks as well as DM vendor oversight to meet aggressive timelines of high‑quality data deliverables
Analytical and problem‑solving capabilities
Excellent verbal and written communication skills
Professional interpersonal skills
Ability to work well with a multi‑disciplinary team of professionals
Flexible attitude with respect to work assignments and new learning
Ability to prioritize workload
Superior attention to detail
Understanding of clinical research and the relationship of Data Management in the clinical study process
Strong technical aptitude and ability to adapt to multiple data management platforms
Strong knowledge of electronic data capture (EDC) clinical data management systems
Strong computer skills (Microsoft Office Suite, Medidata Rave) and ability to understand and adapt to various information technology (IT) systems
The salary range for the Senior Data Manager is expected to be between $175,000 and $190,000 per year. Individual pay may vary based on multiple factors including but not limited to relevant job‑related skills, experience, education or training, market factors, and work location.
At Vor, we support our team with robust benefits, including comprehensive health coverage, flexible paid time off, generous parental leave, and a competitive 401(k). From education assistance to wellness resources and financial security, we invest in your well‑being so you can thrive at work and beyond.
As an equal opportunity employer, we at Vor Bio know that diversity inspires innovation, inclusiveness, and creativity. We invite you to come as you are. All applicants will be considered for employment agnostic to race, age, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.
Please visit our website at https://www.vorbio.com/ for more information.
#J-18808-Ljbffr