Eli Lilly and Company
Structural Biologist (R5-R7)
Eli Lilly and Company, San Diego, California, United States, 92189
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.
Eli Lilly and Company seeks a Structural Biologist (R5-R7) to support structure-based drug discovery (SBDD) projects focused on G protein-coupled receptors (GPCRs). Perform structure determination and drug design for GPCR and membrane protein targets as well as soluble protein targets. Apply biochemical, biophysical, and computational techniques to accelerate generation of high-quality reagents for X-ray crystallography and cryogenic electron microscopy (cryo-EM) studies. Determine structures and co-complex structures of protein targets for the design of small-molecule and antibody therapeutics. Develop integrative approaches to SBDD incorporating data and input from structural biology, biophysics, protein biochemistry, and medicinal chemistry teams.
Minimum Requirements:
Ph.D. in Structural Biology, Biophysics, Biochemistry, Chemistry, or a related field.
2 years of academic or employment experience with GPCR biology, pharmacology, and structure-based research studies of GPCRs.
2 years of experience with protein engineering, protein biochemistry, and protein structure determination by X-ray crystallography or cryo-EM.
2 years of experience with construct design, molecular cloning, and protein expression and purification.
2 years of experience with chromatographic methods for isolating recombinant proteins and HPLC/FPLC systems.
2 years of experience with SDS-PAGE, Western blot, thermal shift assays, and ELISA.
2 years of experience with computational tools for protein structure determination and analysis, including CCP4, Phenix, COOT, PyMol, and Chimera.
Job location: San Diego, CA. RATE OF PAY: $168,709.00 - $178,709.00 per year. To apply, please visit
https://jobsearch.lilly.com/
and enter job requisition number
R-84158
when prompted. Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (
https://careers.lilly.com/us/en/workplace-accommodation
) for further assistance. Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.
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https://jobsearch.lilly.com/
and enter job requisition number
R-84158
when prompted. Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (
https://careers.lilly.com/us/en/workplace-accommodation
) for further assistance. Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.
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