KYMERA THERAPEUTICS
Senior Medical Director, Rheumatology
KYMERA THERAPEUTICS, Oklahoma City, Oklahoma, United States
Who we are:
Kymera is a clinical‑stage biotechnology company pioneering the field of targeted protein degradation (TPD) to develop medicines that address critical health problems and have the potential to dramatically improve patients’ lives. Kymera is deploying TPD to address disease targets and pathways inaccessible with conventional therapeutics. Having advanced the first degrader into the clinic for immunological diseases, Kymera is focused on building an industry‑leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly effective therapies for patients with these conditions. Founded in 2016, Kymera has been recognized as one of Boston’s top workplaces for the past several years. For more information about our science, pipeline and people, please visit www.kymeratx.com or follow us on X (formerly Twitter) or LinkedIn.
How we work:
PIONEER : We are courageous, resilient and rigorous in our mission to improve patients’ lives through our revolutionary degrader medicines.
COLLABORATE : We value trust + transparency from everyone. Our goals are shared, our decisions data‑driven and our camaraderie genuine.
BELONG : We recognize our differences, inviting curiosity and inclusivity, so that our people are valued, seen, and heard.
How you’ll make an impact: The Senior Medical Director, IRF5 Program will serve as the clinical lead for one or more indications within Kymera’s IRF5 clinical development program, a first‑in‑class therapeutic approach, leveraging targeted protein degradation to modulate innate immune signaling in immune‑mediated diseases. This individual will be responsible for driving the clinical strategy of the program, including clinical trial design, execution, data interpretation, and regulatory interactions. This is a unique opportunity to help shape the clinical development of a first‑in‑class therapy with the potential to transform treatment paradigms in autoimmune disease. This role requires deep clinical insight, cross‑functional collaboration, and leadership in advancing novel therapies from early clinical development through late‑stage trials.
Serve as the clinical lead for one or more clinical indications within the IRF5 program, overseeing all aspects of clinical strategy and execution.
Integrate translational and biomarker data into clinical strategy to refine patient selection and endpoint development.
Lead the design and implementation of clinical studies, ensuring scientific rigor and patient safety.
Collaborate with external partners, academic institutions, and consortia to advance the scientific and clinical development strategy.
Provide strategic medical leadership to cross‑functional teams, including development sub‑teams and clinical study teams.
Provide medical oversight during clinical trial conduct, including safety monitoring, data review, and protocol amendments as needed.
Contribute to the development of clinical and regulatory documents (protocols, IBs, CSRs, regulatory submissions).
Contribute to hiring, coaching, and development of clinical development talent.
Represent Kymera in scientific, regulatory, and clinical forums, including interactions with KOLs, investigators, and advisory boards.
Skills and experience you’ll bring:
MD or MD/PhD with board certification in Rheumatology, Immunology, or a related discipline. Candidates with alternative certifications and substantial clinical development experience in relevant therapeutic areas will also be considered. Minimum of 4 years of experience in clinical drug development, ideally in biotechnology or pharmaceutical settings.
Experience interacting with global regulatory agencies (e.g., FDA, EMA) and preparing briefing documents for regulatory submissions.
Proven track record in designing and executing clinical trials (Phase I–III) and contributing to successful regulatory interactions.
Strong understanding of translational science, biomarkers, and mechanistic drug development.
Demonstrated ability to lead cross‑functional teams and manage multiple programs in parallel.
Entrepreneurial mindset and passion for advancing first‑in‑class therapies in a collaborative, science‑driven environment.
Excellent leadership, communication, and collaborative skills; ability to thrive in a fast‑paced, matrixed environment.
Equal Employment Opportunity
Kymera Therapeutics is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment. All applicants will receive consideration for employment without regard to race, color, religion, creed, gender, national origin, age, disability, veteran status, pregnancy, sex, marital status, gender expression or identity, genetic information, sexual orientation, citizenship, or any other legally protected class.
Compensation
Kymera offers a competitive compensation package that recognizes both results and capabilities through market‑based, performance‑driven pay.
The anticipated base salary range for this role is $330,000 – $380,000, with eligibility for annual bonus, equity participation, and comprehensive benefits.
Actual salary is based on a holistic evaluation of the specific role/level as well as each candidate’s depth of experience and the capabilities they bring to the position.
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How we work:
PIONEER : We are courageous, resilient and rigorous in our mission to improve patients’ lives through our revolutionary degrader medicines.
COLLABORATE : We value trust + transparency from everyone. Our goals are shared, our decisions data‑driven and our camaraderie genuine.
BELONG : We recognize our differences, inviting curiosity and inclusivity, so that our people are valued, seen, and heard.
How you’ll make an impact: The Senior Medical Director, IRF5 Program will serve as the clinical lead for one or more indications within Kymera’s IRF5 clinical development program, a first‑in‑class therapeutic approach, leveraging targeted protein degradation to modulate innate immune signaling in immune‑mediated diseases. This individual will be responsible for driving the clinical strategy of the program, including clinical trial design, execution, data interpretation, and regulatory interactions. This is a unique opportunity to help shape the clinical development of a first‑in‑class therapy with the potential to transform treatment paradigms in autoimmune disease. This role requires deep clinical insight, cross‑functional collaboration, and leadership in advancing novel therapies from early clinical development through late‑stage trials.
Serve as the clinical lead for one or more clinical indications within the IRF5 program, overseeing all aspects of clinical strategy and execution.
Integrate translational and biomarker data into clinical strategy to refine patient selection and endpoint development.
Lead the design and implementation of clinical studies, ensuring scientific rigor and patient safety.
Collaborate with external partners, academic institutions, and consortia to advance the scientific and clinical development strategy.
Provide strategic medical leadership to cross‑functional teams, including development sub‑teams and clinical study teams.
Provide medical oversight during clinical trial conduct, including safety monitoring, data review, and protocol amendments as needed.
Contribute to the development of clinical and regulatory documents (protocols, IBs, CSRs, regulatory submissions).
Contribute to hiring, coaching, and development of clinical development talent.
Represent Kymera in scientific, regulatory, and clinical forums, including interactions with KOLs, investigators, and advisory boards.
Skills and experience you’ll bring:
MD or MD/PhD with board certification in Rheumatology, Immunology, or a related discipline. Candidates with alternative certifications and substantial clinical development experience in relevant therapeutic areas will also be considered. Minimum of 4 years of experience in clinical drug development, ideally in biotechnology or pharmaceutical settings.
Experience interacting with global regulatory agencies (e.g., FDA, EMA) and preparing briefing documents for regulatory submissions.
Proven track record in designing and executing clinical trials (Phase I–III) and contributing to successful regulatory interactions.
Strong understanding of translational science, biomarkers, and mechanistic drug development.
Demonstrated ability to lead cross‑functional teams and manage multiple programs in parallel.
Entrepreneurial mindset and passion for advancing first‑in‑class therapies in a collaborative, science‑driven environment.
Excellent leadership, communication, and collaborative skills; ability to thrive in a fast‑paced, matrixed environment.
Equal Employment Opportunity
Kymera Therapeutics is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment. All applicants will receive consideration for employment without regard to race, color, religion, creed, gender, national origin, age, disability, veteran status, pregnancy, sex, marital status, gender expression or identity, genetic information, sexual orientation, citizenship, or any other legally protected class.
Compensation
Kymera offers a competitive compensation package that recognizes both results and capabilities through market‑based, performance‑driven pay.
The anticipated base salary range for this role is $330,000 – $380,000, with eligibility for annual bonus, equity participation, and comprehensive benefits.
Actual salary is based on a holistic evaluation of the specific role/level as well as each candidate’s depth of experience and the capabilities they bring to the position.
#J-18808-Ljbffr