Tango Therapeutics
Vice President, Safety and Pharmacovigilance
Tango Therapeutics, Boston, Massachusetts, us, 02298
Vice President, Safety and Pharmacovigilance
Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer. Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer. This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing. The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts.
Tango Therapeutics is seeking an innovative and collaborative leader to serve as Vice President, Safety and Pharmacovigilance. Reporting to the SVP, Head of Clinical Development this individual will provide strategic direction and day-to-day leadership for the Medical Safety Science function. This individual will manage the Pharmacovigilance team and play an important role in guiding the company’s safety strategy, supporting global regulatory interactions, contributing to portfolio governance, and informing long-term planning. The ideal candidate brings strong clinical knowledge, broad pharmacovigilance expertise, and the ability to work effectively across teams and with external stakeholders.
Your Role
Lead and oversee all pharmacovigilance and risk management activities for Tango’s clinical programs
Develop and execute comprehensive safety science strategies for oncology drug development programs from preclinical through post-market surveillance
Provide safety expertise and risk-benefit assessments to support go/no-go decisions for oncology programs
Represent Tango in interactions with health authorities, including preparing and presenting safety data in regulatory meetings
Provide medical safety expertise and leadership across all clinical development activities, including protocols, CSRs, IBs, ICFs, and regulatory briefing books
Oversee signal detection, safety surveillance, and benefit-risk assessments, implementing risk mitigation strategies as needed
Direct the preparation and review of key safety documents, including DSURs, SUSARs, periodic and annual safety reports, and regulatory communications
Develop and manage PV budgets, ensuring alignment with corporate objectives
Oversee the development and execution of safety processes, standards, and technologies to improve efficiency, scalability, and scientific quality
Direct the preparation of safety sections for regulatory submissions including INDs, NDAs, BLAs, and periodic safety reports
Oversee the development of safety monitoring plans and data safety monitoring boards for clinical trials
Build and lead a high-performing global safety science organization
Lead cross-functional safety teams and collaborate with clinical development, regulatory affairs, medical affairs, and commercial teams
Mentor and develop safety professionals, fostering a culture of scientific rigor and patient focus
Represent the company at regulatory meetings, scientific conferences, and industry forums
Collaborate with external partners including CROs, academic institutions, and regulatory consultants
Champion patient safety as a core organizational value
What Bring
MD and 10+ years of experience in pharmacovigilance, safety science, or related roles within the pharmaceutical/biotech industry
Deep understanding of oncology drug development, including novel therapies (immunotherapy, targeted therapy, cell therapy)
Strong strategic thinking and business acumen
Excellent communication skills with ability to present complex safety data to various stakeholders
Expertise in global pharmacovigilance regulations, safety surveillance, reporting, and risk management strategies
Experience with regulatory authority interactions, safety database applications, and safety signal detection methodologies
Strong leadership skills with a proven track record of building and managing safety teams
Effective communicator with excellent written, verbal, and presentation skills
Ability to thrive in a fast-paced, high-growth environment, balancing multiple priorities while maintaining a strong commitment to ethical standards
We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.
Salary range: $311,200 - $466,800 USD
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Tango Therapeutics is seeking an innovative and collaborative leader to serve as Vice President, Safety and Pharmacovigilance. Reporting to the SVP, Head of Clinical Development this individual will provide strategic direction and day-to-day leadership for the Medical Safety Science function. This individual will manage the Pharmacovigilance team and play an important role in guiding the company’s safety strategy, supporting global regulatory interactions, contributing to portfolio governance, and informing long-term planning. The ideal candidate brings strong clinical knowledge, broad pharmacovigilance expertise, and the ability to work effectively across teams and with external stakeholders.
Your Role
Lead and oversee all pharmacovigilance and risk management activities for Tango’s clinical programs
Develop and execute comprehensive safety science strategies for oncology drug development programs from preclinical through post-market surveillance
Provide safety expertise and risk-benefit assessments to support go/no-go decisions for oncology programs
Represent Tango in interactions with health authorities, including preparing and presenting safety data in regulatory meetings
Provide medical safety expertise and leadership across all clinical development activities, including protocols, CSRs, IBs, ICFs, and regulatory briefing books
Oversee signal detection, safety surveillance, and benefit-risk assessments, implementing risk mitigation strategies as needed
Direct the preparation and review of key safety documents, including DSURs, SUSARs, periodic and annual safety reports, and regulatory communications
Develop and manage PV budgets, ensuring alignment with corporate objectives
Oversee the development and execution of safety processes, standards, and technologies to improve efficiency, scalability, and scientific quality
Direct the preparation of safety sections for regulatory submissions including INDs, NDAs, BLAs, and periodic safety reports
Oversee the development of safety monitoring plans and data safety monitoring boards for clinical trials
Build and lead a high-performing global safety science organization
Lead cross-functional safety teams and collaborate with clinical development, regulatory affairs, medical affairs, and commercial teams
Mentor and develop safety professionals, fostering a culture of scientific rigor and patient focus
Represent the company at regulatory meetings, scientific conferences, and industry forums
Collaborate with external partners including CROs, academic institutions, and regulatory consultants
Champion patient safety as a core organizational value
What Bring
MD and 10+ years of experience in pharmacovigilance, safety science, or related roles within the pharmaceutical/biotech industry
Deep understanding of oncology drug development, including novel therapies (immunotherapy, targeted therapy, cell therapy)
Strong strategic thinking and business acumen
Excellent communication skills with ability to present complex safety data to various stakeholders
Expertise in global pharmacovigilance regulations, safety surveillance, reporting, and risk management strategies
Experience with regulatory authority interactions, safety database applications, and safety signal detection methodologies
Strong leadership skills with a proven track record of building and managing safety teams
Effective communicator with excellent written, verbal, and presentation skills
Ability to thrive in a fast-paced, high-growth environment, balancing multiple priorities while maintaining a strong commitment to ethical standards
We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.
Salary range: $311,200 - $466,800 USD
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