10x Genomics
Sr. Manager, Clinical Bioinformatics
10x Genomics, California, Missouri, United States, 65018
About The Role
The Sr. Manager of Clinical Bioinformatics, reporting to the VP, Clinical Applications, will lead the design, development, and implementation of computational pipelines and analytical frameworks supporting 10x Genomics clinical diagnostics. This role bridges advanced single‑cell and spatial genomics with clinical assay development and CLIA operations, ensuring analytical rigor, reproducibility, and compliance.
What You Will Be Doing Scientific and Translational Excellence
Partner with the Diagnostic Assay Development team to integrate informatics approaches into assay design, validation, and performance optimization.
Drive biomarker discovery and translational analyses in large‑scale clinical research studies, including partnerships with leading academic centers processing thousands of tumor and blood samples.
Work with external collaborators to generate and interpret data that demonstrate clinical validity and utility.
Implement robust statistical and computational frameworks to address batch effects, confounding variables, and data harmonization across studies.
Serve as the bioinformatics representative in external 10xDx translational and clinical collaborations.
Maintain deep familiarity with emerging bioinformatics methodologies and clinical genomics standards.
Computational and Analytical Leadership
Lead the design, implementation, and optimization of bioinformatics pipelines for single‑cell and spatial genomics data, from raw data to clinical interpretation.
Establish, maintain, and operate CLIA‑compliant computational workflows, documentation, and quality systems in collaboration with the CLIA Laboratory Director.
Be responsible for data quality control and patient data reporting.
Develop and validate algorithms, statistical models, and quality metrics for clinical assay performance.
Direct analytical validation of bioinformatics components in support of LDT assays.
Ensure computational reproducibility, version control, and auditability aligned with CLIA and CAP standards.
Operational Leadership
Build and lead a high‑performing team of bioinformaticians, fostering technical excellence and accountability.
Partner with broader R&D computational biology team for method development and platform improvements.
Define team goals, deliverables, and metrics supporting diagnostic R&D milestones.
Establish data management and computational infrastructure in collaboration with IT, Quality, and CLIA lab teams.
Support publication‑quality analyses and contribute to scientific manuscripts and presentations at major conferences.
Collaboration and Strategic Integration
Work closely with clinical, laboratory, and assay development teams to design studies, interpret results, and implement findings into diagnostic workflows.
Collaborate with regulatory and quality leaders to ensure data integrity and compliance in all analytical systems.
Serve as the bioinformatics representative during audits, partner reviews, and cross‑functional readiness assessments.
Contribute to defining the broader clinical bioinformatics strategy and diagnostic roadmap for 10xDx.
To Be Successful In This Role You Will Need
Ph.D. in Bioinformatics, Computational Biology, Genomics, or a related field.
Minimum 10 years of experience in bioinformatics for clinical or diagnostic applications, including leadership of high‑impact computational teams.
Deep expertise in NGS, single‑cell, and/or spatial data analysis, from primary data processing through interpretation.
Proficiency in R, Python, and major bioinformatics toolkits; familiarity with cloud or high‑performance computing.
Demonstrated success collaborating with experimental scientists and clinicians on translational and diagnostic projects.
Strong publication record in computational biology, genomics, or diagnostics.
Additionally, You Are
Detail‑oriented and quality‑driven, with a deep respect for validation and rigor.
Strategic thinker who also thrives in hands‑on analytical and computational work.
Effective communicator and collaborator across scientific, operational, and executive teams.
Motivated by building new capabilities at the intersection of genomics, computation, and clinical medicine.
Pay Range $213,900—$289,500 USD
About 10x Genomics At 10x Genomics, accelerating our understanding of biology is more than a mission for us. It is a commitment. We enable scientists to advance their research, allowing them to address scientific questions they did not even know they could ask. Our tools have enabled fundamental discoveries across biology including cancer, immunology, and neuroscience. Our teams are empowered and encouraged to follow their passions, pursue new ideas, and perform at their best in an inclusive and dynamic environment.
Individuals seeking employment at 10x Genomics are considered without regards to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation, or any other characteristic protected by applicable law.
10x does not accept unsolicited applicants submitted by third‑party recruiters or agencies. Any resume or application submitted to 10x without a vendor agreement in place will be considered unsolicited and property of 10x, and 10x will not pay a placement fee.
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What You Will Be Doing Scientific and Translational Excellence
Partner with the Diagnostic Assay Development team to integrate informatics approaches into assay design, validation, and performance optimization.
Drive biomarker discovery and translational analyses in large‑scale clinical research studies, including partnerships with leading academic centers processing thousands of tumor and blood samples.
Work with external collaborators to generate and interpret data that demonstrate clinical validity and utility.
Implement robust statistical and computational frameworks to address batch effects, confounding variables, and data harmonization across studies.
Serve as the bioinformatics representative in external 10xDx translational and clinical collaborations.
Maintain deep familiarity with emerging bioinformatics methodologies and clinical genomics standards.
Computational and Analytical Leadership
Lead the design, implementation, and optimization of bioinformatics pipelines for single‑cell and spatial genomics data, from raw data to clinical interpretation.
Establish, maintain, and operate CLIA‑compliant computational workflows, documentation, and quality systems in collaboration with the CLIA Laboratory Director.
Be responsible for data quality control and patient data reporting.
Develop and validate algorithms, statistical models, and quality metrics for clinical assay performance.
Direct analytical validation of bioinformatics components in support of LDT assays.
Ensure computational reproducibility, version control, and auditability aligned with CLIA and CAP standards.
Operational Leadership
Build and lead a high‑performing team of bioinformaticians, fostering technical excellence and accountability.
Partner with broader R&D computational biology team for method development and platform improvements.
Define team goals, deliverables, and metrics supporting diagnostic R&D milestones.
Establish data management and computational infrastructure in collaboration with IT, Quality, and CLIA lab teams.
Support publication‑quality analyses and contribute to scientific manuscripts and presentations at major conferences.
Collaboration and Strategic Integration
Work closely with clinical, laboratory, and assay development teams to design studies, interpret results, and implement findings into diagnostic workflows.
Collaborate with regulatory and quality leaders to ensure data integrity and compliance in all analytical systems.
Serve as the bioinformatics representative during audits, partner reviews, and cross‑functional readiness assessments.
Contribute to defining the broader clinical bioinformatics strategy and diagnostic roadmap for 10xDx.
To Be Successful In This Role You Will Need
Ph.D. in Bioinformatics, Computational Biology, Genomics, or a related field.
Minimum 10 years of experience in bioinformatics for clinical or diagnostic applications, including leadership of high‑impact computational teams.
Deep expertise in NGS, single‑cell, and/or spatial data analysis, from primary data processing through interpretation.
Proficiency in R, Python, and major bioinformatics toolkits; familiarity with cloud or high‑performance computing.
Demonstrated success collaborating with experimental scientists and clinicians on translational and diagnostic projects.
Strong publication record in computational biology, genomics, or diagnostics.
Additionally, You Are
Detail‑oriented and quality‑driven, with a deep respect for validation and rigor.
Strategic thinker who also thrives in hands‑on analytical and computational work.
Effective communicator and collaborator across scientific, operational, and executive teams.
Motivated by building new capabilities at the intersection of genomics, computation, and clinical medicine.
Pay Range $213,900—$289,500 USD
About 10x Genomics At 10x Genomics, accelerating our understanding of biology is more than a mission for us. It is a commitment. We enable scientists to advance their research, allowing them to address scientific questions they did not even know they could ask. Our tools have enabled fundamental discoveries across biology including cancer, immunology, and neuroscience. Our teams are empowered and encouraged to follow their passions, pursue new ideas, and perform at their best in an inclusive and dynamic environment.
Individuals seeking employment at 10x Genomics are considered without regards to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation, or any other characteristic protected by applicable law.
10x does not accept unsolicited applicants submitted by third‑party recruiters or agencies. Any resume or application submitted to 10x without a vendor agreement in place will be considered unsolicited and property of 10x, and 10x will not pay a placement fee.
#J-18808-Ljbffr