Allen Spolden
Director or Associate Director, Medicinal Chemistry
Allen Spolden, San Diego, California, United States, 92189
Director or Associate Director, Medicinal Chemistry
La Jolla, United States | Posted on 09/19/2024
Industry Pharma/Biotech/Clinical Research
Work Experience 5+ years
State/Province California
Country United States
Job Description We seek an experienced and creative medicinal chemist with a proven track record of success in drug discovery. Candidates should be motivated to work in an intensely collaborative, multidisciplinary, team-based setting. The role will entail coordinating a medicinal chemistry team with internal and external experimental capabilities, as well as proactively interfacing with diverse teams working on automated experimentation, AI-driven molecular generation, property predictions, and bioassay data generation.
KEY RESPONSIBILITIES
Lead a group of medicinal chemists and drive molecular discovery efforts to deliver development and clinical candidates
Devise strategies to identify lead molecules and optimize them for potency, selectivity, and ADME properties using multivariant SAR analysis and hypothesis driven design principles
Work closely with molecular and cellular biology, pharmacology, computational chemistry, ADME, and other key functions
Act as liaison between Entos, CROs, and other external partners
Influence the prospective use of computational methods and leverage automated synthesis and high-throughput experimentation capabilities
Work closely with AI/ML teams to develop and implement relevant predictive models to aid in the design of new molecules
Communicate project updates clearly and effectively to the broader team and key stakeholders
Work as a senior member of the Chemistry research group and foster a culture of scientific excellence, innovation, and teamwork
PREFERRED QUALIFICATIONS
A Ph.D./Postdoc in organic chemistry with 8 or more years of experience in Pharma/Bio-tech drug discovery
Expert in modern synthetic organic chemistry approaches and principles demonstrated through publications in journals and patents
Ability to integrate multiple R&D disciplines into a successful strategic project plan
Experience in leading projects and driving programs through the preclinical development process
Experience working with computational chemists as part of project team in design of drug targets is required
Strong interpersonal, communication, time management, and leadership skills
Experience mentoring or leading junior chemists
Creative problem solving and management of relationships with several stakeholders within and beyond the company
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Industry Pharma/Biotech/Clinical Research
Work Experience 5+ years
State/Province California
Country United States
Job Description We seek an experienced and creative medicinal chemist with a proven track record of success in drug discovery. Candidates should be motivated to work in an intensely collaborative, multidisciplinary, team-based setting. The role will entail coordinating a medicinal chemistry team with internal and external experimental capabilities, as well as proactively interfacing with diverse teams working on automated experimentation, AI-driven molecular generation, property predictions, and bioassay data generation.
KEY RESPONSIBILITIES
Lead a group of medicinal chemists and drive molecular discovery efforts to deliver development and clinical candidates
Devise strategies to identify lead molecules and optimize them for potency, selectivity, and ADME properties using multivariant SAR analysis and hypothesis driven design principles
Work closely with molecular and cellular biology, pharmacology, computational chemistry, ADME, and other key functions
Act as liaison between Entos, CROs, and other external partners
Influence the prospective use of computational methods and leverage automated synthesis and high-throughput experimentation capabilities
Work closely with AI/ML teams to develop and implement relevant predictive models to aid in the design of new molecules
Communicate project updates clearly and effectively to the broader team and key stakeholders
Work as a senior member of the Chemistry research group and foster a culture of scientific excellence, innovation, and teamwork
PREFERRED QUALIFICATIONS
A Ph.D./Postdoc in organic chemistry with 8 or more years of experience in Pharma/Bio-tech drug discovery
Expert in modern synthetic organic chemistry approaches and principles demonstrated through publications in journals and patents
Ability to integrate multiple R&D disciplines into a successful strategic project plan
Experience in leading projects and driving programs through the preclinical development process
Experience working with computational chemists as part of project team in design of drug targets is required
Strong interpersonal, communication, time management, and leadership skills
Experience mentoring or leading junior chemists
Creative problem solving and management of relationships with several stakeholders within and beyond the company
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