Scorpion Therapeutics
Senior Director, CVRM Genomics Therapeutic Area Lead
Scorpion Therapeutics, Boston, Massachusetts, us, 02298
Role Summary
Senior Director, CVRM Genomics Therapeutic Area Lead. Lead the CVRM Genomic strategy within CGR, shaping how human genetic and multi-omic evidence informs AstraZeneca’s strategy and pipeline in cardiovascular, renal, and metabolic diseases. Drive target selection, trial design, patient stratification, and biomarker strategy to improve patient outcomes, collaborating across a 60+ partner network and reporting to the VP, CGR Head. Responsibilities
Define and lead the CVRM Genomic strategy for CGR, ensuring alignment to unmet patient needs and therapeutic area priorities. Bring clinical reasoning and genetic insight to identify disease mechanisms, prioritize targets, and develop biomarker and patient identification strategies. Integrate genomic, multi-omic, clinical, biomarker, and real-world evidence to evaluate disease heterogeneity and causal pathways, support mechanism-based development, and inform lifecycle management. Collaborate with CVRM TA leadership to apply population genomic insight for patient selection and disease subtyping, and identify biomarkers for stratification to enhance trial interpretability and success. Lead scientific collaboration across AstraZeneca and the global research community to prioritize high‑value partnerships and investments. Mentor and inspire cross‑functional teams toward shared goals. Qualifications
MD (or international equivalent) and/or relevant PhD with deep CVRM disease biology understanding. 3+ years of experience in clinical research and/or drug development in pharmaceutical or academic environments. Demonstrated ability to apply human genetics or multi‑omics to inform disease mechanisms, patient stratification, therapeutic hypotheses, or clinical trial strategy. Experience in genetic epidemiology and/or rare variant interpretation, including evaluating pathogenicity, penetrance, and clinical relevance. Proven track record leading complex, cross‑functional scientific or clinical research across matrixed teams and external partners. Collaborative, patient‑centered leader who thrives cross‑disciplinarily to solve translational challenges. Experience contributing to clinical trial design, patient enrichment strategies, or biomarker‑driven study planning. Excellent communicator able to convey clinical reasoning and genomic insights to diverse audiences. Ability to influence portfolio and investment decisions through scientific and clinical reasoning. Experience mentoring and developing scientific talent. Desirable Criteria
Recognized scientific contributions (publications, conference presentations, guidelines). Experience leveraging human genomics to inform clinical development, biomarker strategy, or real‑world evidence studies. Familiarity with regulatory, ethical, or privacy considerations for genomic research. Clinical experience.
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Senior Director, CVRM Genomics Therapeutic Area Lead. Lead the CVRM Genomic strategy within CGR, shaping how human genetic and multi-omic evidence informs AstraZeneca’s strategy and pipeline in cardiovascular, renal, and metabolic diseases. Drive target selection, trial design, patient stratification, and biomarker strategy to improve patient outcomes, collaborating across a 60+ partner network and reporting to the VP, CGR Head. Responsibilities
Define and lead the CVRM Genomic strategy for CGR, ensuring alignment to unmet patient needs and therapeutic area priorities. Bring clinical reasoning and genetic insight to identify disease mechanisms, prioritize targets, and develop biomarker and patient identification strategies. Integrate genomic, multi-omic, clinical, biomarker, and real-world evidence to evaluate disease heterogeneity and causal pathways, support mechanism-based development, and inform lifecycle management. Collaborate with CVRM TA leadership to apply population genomic insight for patient selection and disease subtyping, and identify biomarkers for stratification to enhance trial interpretability and success. Lead scientific collaboration across AstraZeneca and the global research community to prioritize high‑value partnerships and investments. Mentor and inspire cross‑functional teams toward shared goals. Qualifications
MD (or international equivalent) and/or relevant PhD with deep CVRM disease biology understanding. 3+ years of experience in clinical research and/or drug development in pharmaceutical or academic environments. Demonstrated ability to apply human genetics or multi‑omics to inform disease mechanisms, patient stratification, therapeutic hypotheses, or clinical trial strategy. Experience in genetic epidemiology and/or rare variant interpretation, including evaluating pathogenicity, penetrance, and clinical relevance. Proven track record leading complex, cross‑functional scientific or clinical research across matrixed teams and external partners. Collaborative, patient‑centered leader who thrives cross‑disciplinarily to solve translational challenges. Experience contributing to clinical trial design, patient enrichment strategies, or biomarker‑driven study planning. Excellent communicator able to convey clinical reasoning and genomic insights to diverse audiences. Ability to influence portfolio and investment decisions through scientific and clinical reasoning. Experience mentoring and developing scientific talent. Desirable Criteria
Recognized scientific contributions (publications, conference presentations, guidelines). Experience leveraging human genomics to inform clinical development, biomarker strategy, or real‑world evidence studies. Familiarity with regulatory, ethical, or privacy considerations for genomic research. Clinical experience.
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