Associate Scientist, Cell Based Assays

We’re seeking a hands‑on scientist to execute high‑throughput cell‑based assays in 384‑well format. You will culture and plate cells, dispense compounds using the Echo, run diverse detection readouts, and analyze dose–response data to deliver high‑quality EC50 results for discovery programs.

Key Responsibilities

Maintain, expand, and plate mammalian cell lines for 384‑well assays

Set up and execute assays with compound dispensing via Labcyte/Beckman Echo

Run and optimize detection formats (e.g., luminescence, cAMP, HTRF/TR‑FRET, fluorescence)

Generate dose–response curves (4‑parameter logistic fits) and report EC50/IC50 with QC

Troubleshoot assay performance, optimize Z’ factors, and document SOPs/results

Collaborate with discovery teams to prioritize studies and timelines

Requirements

BS/MS in Biology, Pharmacology, Biochemistry, or related field; 2+ years industry or equivalent lab experience

Proficiency in mammalian cell culture and 384‑well assay workflows

Hands‑on experience with Echo acoustic dispensing

Experience with plate readers and assay platforms (e.g., cAMP, HTRF, luminescent assays)

Strong data analysis skills: 4PL curve fitting, EC50/IC50 determination, and curve QC (e.g., R², top/bottom constraints)

Detail‑oriented, organized, and comfortable in a fast‑paced, high‑throughput environment

Nice to Have

Experience with automation/LIQ handlers, LIMS/ELN, and statistical QC (Z’, CV, S/B)

Familiarity with GraphPad Prism, ActivityBase, or equivalent analysis tools

Hands‑on experience with Echo acoustic dispensing

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