Takeda
Sr. Scientist, Computational Chemistry
Join to apply for the Sr. Scientist, Computational Chemistry role at Takeda.
Base pay range $137,000.00/yr - $215,270.00/yr
Location Boston, MA
Job Type Full time, Employee
Job Description Objective / Purpose
Work as part of a multidisciplinary team of medicinal chemists, structural biologists, data scientists and biologists and provide computational expertise to advance drug discovery projects
Contribute to drug discovery efforts across various modalities including small molecules, PROTACs, RNA inhibitors, peptides, and more
Implement and execute innovative computational methodologies and tools such as AI, free energy, and cheminformatics approaches to support drug discovery efforts
Accountabilities
Demonstrate an understanding of computational chemistry principles and their application within a multidisciplinary drug discovery environment.
Independently design, develop and execute research assignments, contributing to multiple projects
Identify, develop, validate, and implement innovative computational approaches that enhance research productivity and success
Provide key technical knowledge and input to project teams to drive decision‑making in drug discovery projects
Education & Competencies (Technical and Behavioral) Technical/Functional (Line) Expertise
Experience with a variety of computational tools and methodology including large‑scale virtual screening, ligandability analyses, homology modeling, quantum mechanics, pharmacophore elucidation, machine learning and more against common drug discovery targets (GPCRs, Kinases, etc.)
Comprehensive experience in data mining and data analysis.
Familiarity with organic and synthetic chemistry concepts
Demonstrated ability to provide project teams with computational strategies to inform, influence, and prioritize designs for potency/selectivity and improve ADME/Tox endpoints
Experience developing and deploying design and/or AI platforms to impact drug discovery
Familiarity with standard computational chemistry software including Schrodinger Suites, KNIME, and more
Proficiency in scientific scripting and programming languages including Python
Experience with operations in Linux and/or cloud environments
Leadership
Identifies, plans and executes novel scientific projects and leads platform initiatives.
Decision‑making and Autonomy
Independently manages workload and expectations
Scientifically independent
Influence decision‑making within the department
Lead a computational chemistry initiative such as holo‑structure prediction, ligandability analyses, and large‑scale virtual screening workflows
Interaction
Conduct scientific presentations to internal audiences
Collaborate with cross‑functional scientists and across geographic areas
Innovation
Maintain an interest in cutting‑edge science and act proactively to acquire technologies that match the needs of the team
Receive high‑level instructions on all work, determine methods on new assignments, and work closely with manager
Education, Behavioral Competencies and Skills
PhD degree in Chemistry or equivalent
Expected 2+ years of experience in industry
Compensation and Benefits Summary We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.
U.S. based employees may be eligible for short‑term and/or long‑term incentives. U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short‑term and long‑term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well‑being benefits, among others. U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation.
EEO Statement Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.
Legal Notice It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.
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Base pay range $137,000.00/yr - $215,270.00/yr
Location Boston, MA
Job Type Full time, Employee
Job Description Objective / Purpose
Work as part of a multidisciplinary team of medicinal chemists, structural biologists, data scientists and biologists and provide computational expertise to advance drug discovery projects
Contribute to drug discovery efforts across various modalities including small molecules, PROTACs, RNA inhibitors, peptides, and more
Implement and execute innovative computational methodologies and tools such as AI, free energy, and cheminformatics approaches to support drug discovery efforts
Accountabilities
Demonstrate an understanding of computational chemistry principles and their application within a multidisciplinary drug discovery environment.
Independently design, develop and execute research assignments, contributing to multiple projects
Identify, develop, validate, and implement innovative computational approaches that enhance research productivity and success
Provide key technical knowledge and input to project teams to drive decision‑making in drug discovery projects
Education & Competencies (Technical and Behavioral) Technical/Functional (Line) Expertise
Experience with a variety of computational tools and methodology including large‑scale virtual screening, ligandability analyses, homology modeling, quantum mechanics, pharmacophore elucidation, machine learning and more against common drug discovery targets (GPCRs, Kinases, etc.)
Comprehensive experience in data mining and data analysis.
Familiarity with organic and synthetic chemistry concepts
Demonstrated ability to provide project teams with computational strategies to inform, influence, and prioritize designs for potency/selectivity and improve ADME/Tox endpoints
Experience developing and deploying design and/or AI platforms to impact drug discovery
Familiarity with standard computational chemistry software including Schrodinger Suites, KNIME, and more
Proficiency in scientific scripting and programming languages including Python
Experience with operations in Linux and/or cloud environments
Leadership
Identifies, plans and executes novel scientific projects and leads platform initiatives.
Decision‑making and Autonomy
Independently manages workload and expectations
Scientifically independent
Influence decision‑making within the department
Lead a computational chemistry initiative such as holo‑structure prediction, ligandability analyses, and large‑scale virtual screening workflows
Interaction
Conduct scientific presentations to internal audiences
Collaborate with cross‑functional scientists and across geographic areas
Innovation
Maintain an interest in cutting‑edge science and act proactively to acquire technologies that match the needs of the team
Receive high‑level instructions on all work, determine methods on new assignments, and work closely with manager
Education, Behavioral Competencies and Skills
PhD degree in Chemistry or equivalent
Expected 2+ years of experience in industry
Compensation and Benefits Summary We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.
U.S. based employees may be eligible for short‑term and/or long‑term incentives. U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short‑term and long‑term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well‑being benefits, among others. U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation.
EEO Statement Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.
Legal Notice It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.
#J-18808-Ljbffr