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Position Senior Research Scientist, Cell Engagers
Location Cambridge, MA
Job Overview Pursuant to Section 20 C.F.R. 656.10, you are hereby notified that an application for Alien Employment Certification will be filed by Takeda Development Center Americas, Inc. for the following job opportunity:
Contribute to discovery projects by independently designing and developing well‑defined mechanistic experiments in vitro and ex vivo for projects within oncology cell engager research to identify mechanisms of action (MoA).
Lead from the lab to advance novel and differentiated products in collaboration with cell therapy oncology toward clinical milestones, working collaboratively with internal cross‑functional teams and external partners to incorporate new Vδ1 isolation strategies for use in cell engager programs in vitro.
Propose novel projects based on internal results, external partners, and published reports and demonstrate leadership through effective communication of study plans/value and research results.
Actively participate with the team to isolate and phenotype Vδ1 cells from blood and skin and collaborate with the Cell Therapy team to incorporate new Vδ1 isolation strategies for use in cell engager programs in vitro.
Use immune cell characterization and function assessment—such as multi‑color flow immunophenotyping, multiplex cytokine measurement, cytotoxicity assay, and other molecular‑based assays—to perform analysis, interpret results, and determine appropriate action.
Prepare and present comprehensive technical or project reports, formal presentations, and posters to full range of internal and external audiences, and contribute to IND reports and other regulatory filings.
Maintain laboratory notebooks and keep them in compliance with Takeda policies.
Independently design cytokine fusion strategy to enhance Vδ1 biology for solid tumors.
Help with external collaborations or CROs and establish new protocols.
Up to 20% remote work allowed.
Requirements
Master’s degree in Cancer Immunology and Immunotherapy, Cancer Sciences, or related field plus five years of related experience.
Prior experience must include isolation of Gamma‑Delta T cells from blood and tissue and research on Gamma‑Delta T cell culture and expansion methodology to improve yield and cytotoxicity.
Develop functional and characterization experiments via flow cytometry, spectrometry, and chemiluminescence of isolated Vδ1 cells and analyze experimental data to determine the relevance of results based on background knowledge of Vδ1 gamma‑delta cell biology.
Contribute to evaluation of novel immunotherapy products based on Vδ1 gamma‑delta cell biology.
Experience with gene engineering of Vδ1 cells.
Compensation Full time. $137,000 – $234,800 per year.
Application Qualified applicants can apply at https://jobs.takeda.com. Please reference job #R0168852. EOE
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Position Senior Research Scientist, Cell Engagers
Location Cambridge, MA
Job Overview Pursuant to Section 20 C.F.R. 656.10, you are hereby notified that an application for Alien Employment Certification will be filed by Takeda Development Center Americas, Inc. for the following job opportunity:
Contribute to discovery projects by independently designing and developing well‑defined mechanistic experiments in vitro and ex vivo for projects within oncology cell engager research to identify mechanisms of action (MoA).
Lead from the lab to advance novel and differentiated products in collaboration with cell therapy oncology toward clinical milestones, working collaboratively with internal cross‑functional teams and external partners to incorporate new Vδ1 isolation strategies for use in cell engager programs in vitro.
Propose novel projects based on internal results, external partners, and published reports and demonstrate leadership through effective communication of study plans/value and research results.
Actively participate with the team to isolate and phenotype Vδ1 cells from blood and skin and collaborate with the Cell Therapy team to incorporate new Vδ1 isolation strategies for use in cell engager programs in vitro.
Use immune cell characterization and function assessment—such as multi‑color flow immunophenotyping, multiplex cytokine measurement, cytotoxicity assay, and other molecular‑based assays—to perform analysis, interpret results, and determine appropriate action.
Prepare and present comprehensive technical or project reports, formal presentations, and posters to full range of internal and external audiences, and contribute to IND reports and other regulatory filings.
Maintain laboratory notebooks and keep them in compliance with Takeda policies.
Independently design cytokine fusion strategy to enhance Vδ1 biology for solid tumors.
Help with external collaborations or CROs and establish new protocols.
Up to 20% remote work allowed.
Requirements
Master’s degree in Cancer Immunology and Immunotherapy, Cancer Sciences, or related field plus five years of related experience.
Prior experience must include isolation of Gamma‑Delta T cells from blood and tissue and research on Gamma‑Delta T cell culture and expansion methodology to improve yield and cytotoxicity.
Develop functional and characterization experiments via flow cytometry, spectrometry, and chemiluminescence of isolated Vδ1 cells and analyze experimental data to determine the relevance of results based on background knowledge of Vδ1 gamma‑delta cell biology.
Contribute to evaluation of novel immunotherapy products based on Vδ1 gamma‑delta cell biology.
Experience with gene engineering of Vδ1 cells.
Compensation Full time. $137,000 – $234,800 per year.
Application Qualified applicants can apply at https://jobs.takeda.com. Please reference job #R0168852. EOE
#J-18808-Ljbffr