BioSpace
Senior Principal Engineer - Automation Engineering – Projects and Portfolio Mana
BioSpace, Lebanon, Indiana, United States, 46052
Senior Principal Engineer – Automation Engineering (Projects & Portfolio Manager)
At Eli Lilly, we unite caring with discovery to make life better for people around the world. Our employees around the world work to discover and bring life‑changing medicines to those who need them, improving the understanding and management of disease, and giving back to communities through philanthropy and volunteerism.
We are looking for a Senior Principal Engineer to provide automation support for one or more operating areas and capital projects within the Lilly Medicine Foundry, a new center for advanced manufacturing and drug development. The role focuses on delivering a right‑first‑time facility start‑up, supporting ongoing manufacturing operations, and driving process automation to optimize manufacturing processes, increase clinical trial medicine capacity, and reduce cost and environmental impact. The engineer will lead, mentor, and influence cross‑functional teams to ensure reliable, compliant control applications and systems are used throughout the Foundry.
Responsibilities
Technical Leadership – work with the process control team, including project execution, budgeting, Agile methodology, implementation, and commissioning.
Process control work implementation and coordination.
Develop and implement the Automation Engineering Project Plan and manage the Automation Engineering Portfolio.
Lead/Support project management for the construction and commissioning of the Foundry site.
Work with Automation Leadership for project implementation, from tech transfer to design through validation and production launch.
Track facility construction activities, coordinating with contractors, architects, engineers, and internal stakeholders.
Serve as a liaison between construction teams, manufacturing operations, engineering, and regulatory affairs to ensure alignment and timely decision‑making.
Develop and manage detailed project timelines, budgets and resource allocations; proactively identify and mitigate risks.
Ensure all facility design and construction activities adhere to Good Manufacturing Practices (GMP) and regulatory requirements for radiopharmaceutical production.
Manage internal and external project teams, providing clear direction, accountability, and communication.
Prepare and deliver regular updates and presentations to the Automation Engineering Leadership, Foundry Leadership, cross‑functional teams and external partners as required.
Support the planning and facilitate the transition from construction to operational readiness, including facility qualification, equipment validation, and staff training.
Implement project management tools and best practices for tracking progress, reporting, and documentation.
Support and maintain the validated state of the site control systems in line with Lilly quality standards during the development and execution of validation strategies and associated documentation.
Automation support for capital projects including new product introductions.
Promote the use of automation to improve productivity, operational efficiency and compliance.
Develop a network of corporate contacts and leverage corporate expertise when needed.
Foster a culture of safety and compliance, ensuring all personnel follow HSE protocols.
In coordination with automation and compliance consultants, set and reinforce standards for appropriate rigor in automation work products.
Demonstrated initiative, good planning and organizational skills, ability to prioritize tasks, commitment to task completion and timelines.
Possess a keen technical curiosity and has demonstrated strong problem‑solving skills and a desire for continuous improvement.
Demonstrated ability to influence peers and business partners.
Good written and verbal communication skills for both technical and non‑technical audiences.
Knowledge of GMP, regulatory requirements, computer system validation.
Basic Requirements
Minimum B.S. in Engineering with a minimum of 8+ years working experience in biopharma engineering, operations, or manufacturing.
Experience in project management preferably in the field of automation engineering, in major pharmaceutical companies and in manufacturing operations with extensive system integration of applications, systems and platforms.
Additional Preferences
Experience in leading commissioning, qualifying and supporting systems between SCADA, DCS, MES, LIMS, Historian and other applications for interconnectivity.
Experience in implementing project management and portfolio tools for optimization.
Experience in managing assets in CMMS particularly budgets, purchase orders, contracts and portfolio.
Experience in implementing Agile methodology, Scrum and Kanban.
Experience in facilitating and driving decision‑making at an organizational level.
Experience in project management during tech transfer, design, development, commissioning and qualification of highly automated greenfield manufacturing sites utilizing SCADA, DCS, MES, LIMS, site historian systems, middleware applications (DeltaV, Rockwell, Building Management Systems, MES, LIMS, OSI‑PI, OPC).
Other Information
Initial location: Lilly Technology Center, Indianapolis.
Permanent location: Lilly Medicines Foundry, Lebanon, Indiana.
Compensation & Benefits Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is $66,000 - $171,600. Full‑time employees will also be eligible for a company bonus. In addition, Lilly offers a comprehensive benefit program to eligible employees, including a 401(k) plan, pension, vacation benefits, medical, dental, vision and prescription drug benefits, flexible benefits, life insurance, time‑off and leave policies, and well‑being benefits.
Equal Opportunity Statement Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status. Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace‑accommodation) for further assistance. Our employee resource groups (ERGs) offer strong support networks to all employees and include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.
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We are looking for a Senior Principal Engineer to provide automation support for one or more operating areas and capital projects within the Lilly Medicine Foundry, a new center for advanced manufacturing and drug development. The role focuses on delivering a right‑first‑time facility start‑up, supporting ongoing manufacturing operations, and driving process automation to optimize manufacturing processes, increase clinical trial medicine capacity, and reduce cost and environmental impact. The engineer will lead, mentor, and influence cross‑functional teams to ensure reliable, compliant control applications and systems are used throughout the Foundry.
Responsibilities
Technical Leadership – work with the process control team, including project execution, budgeting, Agile methodology, implementation, and commissioning.
Process control work implementation and coordination.
Develop and implement the Automation Engineering Project Plan and manage the Automation Engineering Portfolio.
Lead/Support project management for the construction and commissioning of the Foundry site.
Work with Automation Leadership for project implementation, from tech transfer to design through validation and production launch.
Track facility construction activities, coordinating with contractors, architects, engineers, and internal stakeholders.
Serve as a liaison between construction teams, manufacturing operations, engineering, and regulatory affairs to ensure alignment and timely decision‑making.
Develop and manage detailed project timelines, budgets and resource allocations; proactively identify and mitigate risks.
Ensure all facility design and construction activities adhere to Good Manufacturing Practices (GMP) and regulatory requirements for radiopharmaceutical production.
Manage internal and external project teams, providing clear direction, accountability, and communication.
Prepare and deliver regular updates and presentations to the Automation Engineering Leadership, Foundry Leadership, cross‑functional teams and external partners as required.
Support the planning and facilitate the transition from construction to operational readiness, including facility qualification, equipment validation, and staff training.
Implement project management tools and best practices for tracking progress, reporting, and documentation.
Support and maintain the validated state of the site control systems in line with Lilly quality standards during the development and execution of validation strategies and associated documentation.
Automation support for capital projects including new product introductions.
Promote the use of automation to improve productivity, operational efficiency and compliance.
Develop a network of corporate contacts and leverage corporate expertise when needed.
Foster a culture of safety and compliance, ensuring all personnel follow HSE protocols.
In coordination with automation and compliance consultants, set and reinforce standards for appropriate rigor in automation work products.
Demonstrated initiative, good planning and organizational skills, ability to prioritize tasks, commitment to task completion and timelines.
Possess a keen technical curiosity and has demonstrated strong problem‑solving skills and a desire for continuous improvement.
Demonstrated ability to influence peers and business partners.
Good written and verbal communication skills for both technical and non‑technical audiences.
Knowledge of GMP, regulatory requirements, computer system validation.
Basic Requirements
Minimum B.S. in Engineering with a minimum of 8+ years working experience in biopharma engineering, operations, or manufacturing.
Experience in project management preferably in the field of automation engineering, in major pharmaceutical companies and in manufacturing operations with extensive system integration of applications, systems and platforms.
Additional Preferences
Experience in leading commissioning, qualifying and supporting systems between SCADA, DCS, MES, LIMS, Historian and other applications for interconnectivity.
Experience in implementing project management and portfolio tools for optimization.
Experience in managing assets in CMMS particularly budgets, purchase orders, contracts and portfolio.
Experience in implementing Agile methodology, Scrum and Kanban.
Experience in facilitating and driving decision‑making at an organizational level.
Experience in project management during tech transfer, design, development, commissioning and qualification of highly automated greenfield manufacturing sites utilizing SCADA, DCS, MES, LIMS, site historian systems, middleware applications (DeltaV, Rockwell, Building Management Systems, MES, LIMS, OSI‑PI, OPC).
Other Information
Initial location: Lilly Technology Center, Indianapolis.
Permanent location: Lilly Medicines Foundry, Lebanon, Indiana.
Compensation & Benefits Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is $66,000 - $171,600. Full‑time employees will also be eligible for a company bonus. In addition, Lilly offers a comprehensive benefit program to eligible employees, including a 401(k) plan, pension, vacation benefits, medical, dental, vision and prescription drug benefits, flexible benefits, life insurance, time‑off and leave policies, and well‑being benefits.
Equal Opportunity Statement Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status. Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace‑accommodation) for further assistance. Our employee resource groups (ERGs) offer strong support networks to all employees and include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.
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