Prellis Biologics
Sr. Associate Scientitst -Cell Culture and Reagent Development
Prellis Biologics, Berkeley, California, United States, 94709
Sr. Associate Scientist - Cell Culture and Reagent Development
Position Overview
Prellis Biologics uses proprietary technology to 3D print lymph node organoids, which we use for generating antigen‑specific B‑cells and ultimately in‑vitro antibody libraries for multiple targets. We are seeking a highly motivated Senior Associate Scientist with a strong background in cellular biology to join our team on a contract basis. In this role the individual will support our ex‑vivo antibody production efforts and develop detection reagents for flow cytometry. The ideal candidate will have a strong background in cell biology, biomolecular techniques, and experience in flow cytometry and production environments.
Primary Responsibilities
Routinely utilize standardized cell culture methods to elicit antigen‑specific B cells.
Independently perform single‑cell sorting for downstream analysis following detailed work instructions.
Routinely synthesize flow cytometry detection reagents, including but not limited to biotinylated proteins, streptavidin tetramers, and fluorescently labeled proteins.
Utilize a broad suite of biomolecular and biochemical assays including flow cytometry, SDS‑PAGE, mass spectrometry, and UV‑Vis to characterize reagents.
Troubleshoot biotinylation or tetramer generation as needed, optimize workflow for degree of labeling and on‑cell detection using flow cytometry.
Maintain detailed, accurate, and timely documentation of all experiments in electronic lab notebooks (ELN).
Collaborate closely with cross‑functional teams to support project goals.
Contribute to data interpretation and troubleshooting efforts as needed.
Required Qualifications
B.S. or M.S. in Cell Biology, Molecular Biology, Biochemistry, Chemistry, Biomedical Engineering, or a related field with 3+ years of hands‑on laboratory work (industry experience strongly preferred).
Demonstrated experience in mammalian cell culture, flow cytometry, and bioanalytical assays such as SDS‑PAGE, UV‑Vis.
Comfortable working with LIMS/ELN systems such as Benchling.
Demonstrated ability to work independently in a laboratory setting.
Strong organizational skills and excellent attention to detail.
Effective written and verbal communication skills.
Ability to work well both independently and in a collaborative, team‑oriented environment.
Proactive, collaborative, and adaptable in a dynamic research setting.
Preferred Experience
Working knowledge of immunology and biochemistry.
Flow cytometry techniques and bead‑based assays for reagent QC.
About Prellis Biologics At Prellis we integrate human biology with machine learning. We aim to revolutionize drug discovery by harnessing the power of the human immune system with tightly integrated machine learning to develop next‑generation antibody therapeutics with unparalleled speed, precision, and safety. We are committed to empowering our pharmaceutical partners with access to the most promising fully human candidates rapidly identified from the human immune repertoire, enabling them to bring life‑changing treatments to patients faster than ever before. Prellis Biologics is a pre‑IPO biotech located in Berkeley, CA with a team‑oriented, inclusive, and family‑friendly culture. Our growing pipeline targets high unmet patient needs across therapeutics including metabolic, inflammation, and oncology diseases. Prellis has raised funding from top investors, including Celesta, Khosla Ventures, SOSV, and Avidity Partners.
What You Can Expect Of Us We work to develop treatments that take care of others, and we also care for your professional and personal growth and well‑being. From competitive benefits to a collaborative culture, we’ll support your journey every step of the way.
Application Deadline Prellis does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.
Equal Employment Opportunity Statement Prellis Biologics is an equal‑opportunity employer. All applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status. We believe diversity, equity, and inclusion need to be at the foundation of our culture. We work hard to bring together diverse teams—grounded in a wide range of expertise and life experiences—and work even harder to ensure those teams thrive in inclusive, growth‑oriented environments supported by equitable company and team practices. All candidates can expect equitable treatment, respect, and fairness throughout the interview process.
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Primary Responsibilities
Routinely utilize standardized cell culture methods to elicit antigen‑specific B cells.
Independently perform single‑cell sorting for downstream analysis following detailed work instructions.
Routinely synthesize flow cytometry detection reagents, including but not limited to biotinylated proteins, streptavidin tetramers, and fluorescently labeled proteins.
Utilize a broad suite of biomolecular and biochemical assays including flow cytometry, SDS‑PAGE, mass spectrometry, and UV‑Vis to characterize reagents.
Troubleshoot biotinylation or tetramer generation as needed, optimize workflow for degree of labeling and on‑cell detection using flow cytometry.
Maintain detailed, accurate, and timely documentation of all experiments in electronic lab notebooks (ELN).
Collaborate closely with cross‑functional teams to support project goals.
Contribute to data interpretation and troubleshooting efforts as needed.
Required Qualifications
B.S. or M.S. in Cell Biology, Molecular Biology, Biochemistry, Chemistry, Biomedical Engineering, or a related field with 3+ years of hands‑on laboratory work (industry experience strongly preferred).
Demonstrated experience in mammalian cell culture, flow cytometry, and bioanalytical assays such as SDS‑PAGE, UV‑Vis.
Comfortable working with LIMS/ELN systems such as Benchling.
Demonstrated ability to work independently in a laboratory setting.
Strong organizational skills and excellent attention to detail.
Effective written and verbal communication skills.
Ability to work well both independently and in a collaborative, team‑oriented environment.
Proactive, collaborative, and adaptable in a dynamic research setting.
Preferred Experience
Working knowledge of immunology and biochemistry.
Flow cytometry techniques and bead‑based assays for reagent QC.
About Prellis Biologics At Prellis we integrate human biology with machine learning. We aim to revolutionize drug discovery by harnessing the power of the human immune system with tightly integrated machine learning to develop next‑generation antibody therapeutics with unparalleled speed, precision, and safety. We are committed to empowering our pharmaceutical partners with access to the most promising fully human candidates rapidly identified from the human immune repertoire, enabling them to bring life‑changing treatments to patients faster than ever before. Prellis Biologics is a pre‑IPO biotech located in Berkeley, CA with a team‑oriented, inclusive, and family‑friendly culture. Our growing pipeline targets high unmet patient needs across therapeutics including metabolic, inflammation, and oncology diseases. Prellis has raised funding from top investors, including Celesta, Khosla Ventures, SOSV, and Avidity Partners.
What You Can Expect Of Us We work to develop treatments that take care of others, and we also care for your professional and personal growth and well‑being. From competitive benefits to a collaborative culture, we’ll support your journey every step of the way.
Application Deadline Prellis does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.
Equal Employment Opportunity Statement Prellis Biologics is an equal‑opportunity employer. All applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status. We believe diversity, equity, and inclusion need to be at the foundation of our culture. We work hard to bring together diverse teams—grounded in a wide range of expertise and life experiences—and work even harder to ensure those teams thrive in inclusive, growth‑oriented environments supported by equitable company and team practices. All candidates can expect equitable treatment, respect, and fairness throughout the interview process.
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