Merck
Associate Principal Scientist, Analytical R&D
Merck, South San Francisco, California, us, 94083
Associate Principal Scientist, Analytical R&D
Join our Discovery Analytical Research group to drive innovation in analytical measurement technologies, enabling the discovery of new drug candidates across diverse modalities. The Discovery Analytical Research group within Analytical Enabling Capabilities (Analytical R&D) is seeking applicants for an Associate Principal Scientist position available at our research laboratories located in South San Francisco, California.
The successful candidate must be able to collaborate in a dynamic, integrated, and multidisciplinary team environment. A broad range of tools (e.g. high-resolution mass spectrometry, chromatography, spectroscopy) are leveraged, and new technologies are developed to influence selection of new drug candidates and enhance scalability and robustness.
Primary Responsibilities
Enable discovery partner groups with advanced analytical methods
Represent the discovery analytical research group in project teams, provide technical guidance, and drive scientific strategy
Develop, implement, and troubleshoot advanced analytical methods (e.g., high-resolution mass spectrometry, liquid chromatography, capillary electrophoresis, ion chromatography, size exclusion chromatography, and two-dimensional techniques)
Solve complex problems and explore new measurement technologies
Collaborate in multidisciplinary teams, foster partnerships with discovery groups, and contribute to organizational goals
Support junior scientists and promote a culture of learning and innovation
Ensure high standards of data integrity and documentation
Qualifications Education
Bachelor's (with 12 years), Master’s (with 8 years) or Ph.D. (with 4 years) in Analytical Chemistry or related field and relevant experience
Required Experience and Skills
Strong background and extensive hands‑on experience in high‑resolution mass spectrometry of large molecules (proteins, monoclonal antibodies, ADC, etc.) and separation science techniques
Demonstrated scientific ability through publications in peer‑reviewed journals and presentations at scientific conferences
Excellent verbal and written communication skills, demonstrated creativity, and strong interpersonal skills
Ability to deliver complex objectives under challenging timelines in a rapidly changing environment
Ability to work in a team environment with cross‑functional interactions
Preferred Experience and Skills
Knowledge of biochemistry and organic chemistry
Experience with electronic laboratory notebook applications and good documentation practices
Equal Employment Opportunity As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit EEOC Know Your Rights, EEOC GINA Supplement, and learn more about your rights, including under California, Colorado and other U.S. State Acts.
Job Posting End Date: 12/15/2025
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The successful candidate must be able to collaborate in a dynamic, integrated, and multidisciplinary team environment. A broad range of tools (e.g. high-resolution mass spectrometry, chromatography, spectroscopy) are leveraged, and new technologies are developed to influence selection of new drug candidates and enhance scalability and robustness.
Primary Responsibilities
Enable discovery partner groups with advanced analytical methods
Represent the discovery analytical research group in project teams, provide technical guidance, and drive scientific strategy
Develop, implement, and troubleshoot advanced analytical methods (e.g., high-resolution mass spectrometry, liquid chromatography, capillary electrophoresis, ion chromatography, size exclusion chromatography, and two-dimensional techniques)
Solve complex problems and explore new measurement technologies
Collaborate in multidisciplinary teams, foster partnerships with discovery groups, and contribute to organizational goals
Support junior scientists and promote a culture of learning and innovation
Ensure high standards of data integrity and documentation
Qualifications Education
Bachelor's (with 12 years), Master’s (with 8 years) or Ph.D. (with 4 years) in Analytical Chemistry or related field and relevant experience
Required Experience and Skills
Strong background and extensive hands‑on experience in high‑resolution mass spectrometry of large molecules (proteins, monoclonal antibodies, ADC, etc.) and separation science techniques
Demonstrated scientific ability through publications in peer‑reviewed journals and presentations at scientific conferences
Excellent verbal and written communication skills, demonstrated creativity, and strong interpersonal skills
Ability to deliver complex objectives under challenging timelines in a rapidly changing environment
Ability to work in a team environment with cross‑functional interactions
Preferred Experience and Skills
Knowledge of biochemistry and organic chemistry
Experience with electronic laboratory notebook applications and good documentation practices
Equal Employment Opportunity As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit EEOC Know Your Rights, EEOC GINA Supplement, and learn more about your rights, including under California, Colorado and other U.S. State Acts.
Job Posting End Date: 12/15/2025
#J-18808-Ljbffr