FIG Therapeutics, Inc.
Senior Scientist (In Vitro/In Vivo)
FIG Therapeutics, Inc., Valhalla, New York, United States, 10595
Overview
FIG Therapeutics, Inc.
is a preclinical biotech company developing the Symphony platform, a proprietary intratumorally-delivered multimodal gene immunotherapy. The role is a lab-forward Senior Scientist position based in Valhalla, NY (onsite, 5 days/week with occasional weekends). Report directly to the founder and CEO. Exceptional candidates may advance toward co-founder if aligned with the vision. Role summary
We are hiring a hands-on Senior Scientist to lead and execute the majority of pre-IND in vitro and in vivo work, designing, developing, running, qualifying, documenting, and presenting assays and preclinical studies that support IND filing and early CRO/GLP programs. Must-have qualifications
Must have been performed within the last 18 months (non-negotiable): Hands-on generation of CD34⁺ humanized mice and direct experience implanting/maintaining prostate PDX tumors Intratumoral injection and in vivo transfection optimization of PDX tumors Surgical tumor resection/necropsy with downstream tissue processing (IHC/IF and flow) Rational design of lipid nanoparticles for plasmid DNA delivery Viral vector (adenovirus and HSV), RNA, and polycistronic DNA plasmid design Cell culture and transfection/transduction of primary tumor cells, T cells, and cancer cell lines Development of cancer and immune cell co-culture assays Establishment of 3D organoid models of solid tumor TME Assay development for multicolor flow cytometry panels, ELISA, Luminex, ELISPOT, RT-qPCR, and digital PCR (dPCR) Ability to independently design experiments, troubleshoot complex failures, and author SOPs and study reports used to inform CRO/IND decisions Experience coordinating with CROs on GLP-style biodistribution/toxicity/TK studies and contributing to study plans Previous track record of IND support (authoring preclinical sections) and interactions with regulatory consultants Key responsibilities
Design, optimize, and run in-vitro potency & functional assays for multi-domain immune effectors Develop and validate quantitative assays: RT-qPCR, digital PCR (dPCR), ELISA, Luminex multiplex cytokine panels, ELISPOT, Western blot Build, optimize and analyze multicolor flow cytometry panels and perform data analysis (FlowJo/Cytobank) Run in-vitro immune function assays: PBMC cytotoxicity, NK/ADCC, DC activation, antigen-presentation readouts Establish and run tumor microenvironment (TME) models: 2D, 3D spheroids/organoids, tumor:immune co-cultures; provide assay qualification Lead in vivo programs: generation and management of CD34⁺ humanized mice, engraftment of patient-derived prostate PDX, tumor implantation, intratumoral dosing, surgical resection, necropsy, tissue processing for flow/IHC/IF and molecular readouts Design and execute GLP-style biodistribution, PK/PD, and toxicology study plans with CROs; write and review study protocols and reports for IND packages Author SOPs, experimental design docs, technical reports, and contribute to IND-enabling documentation Maintain data integrity, sample tracking, reagent QC; assist with reagent sourcing and basic CMC input Mentor and coordinate work with junior scientists/technicians and external CRO teams Role details
Salary Range: $50,000-$70,000/year + Equity (salary may increase with fundraising). Competitive benefits: health, dental, and vision. Application instructions & required verification materials
All of the following are required to be considered for the role. Email Cover Letter and CV to ariel@figtherapeutics.com. Do not use AI for the cover letter, as it would disqualify the application. Curriculum vitae (with dates and affiliations). Cover letter demonstrating understanding of the responsibilities as the first non-founder scientist hire in a small biotech, explicitly mapping how you meet each Must-Have item with dates (month/year) and employer/lab. Three professional references (name, title, phone, e-mail) to verify required experiences; include these references at the end of the CV. Permission to perform background check and employment verification. Willingness to sign a declaration that information provided is true and accurate. Applications not including the above materials will be rejected. Compliance & policy
Strict verification and disqualification policy: must have performed each Must-Have activity within the past 18 months and provide documentary evidence and references. Offers contingent on verification of employment, education, references, and background checks. State compliance and notices for criminal-history information where applicable. New York Clean Slate Act considerations apply as required. Equal Employment Opportunity & Workplace Policy: FIG Therapeutics is an equal opportunity employer. Decisions made without regard to race, color, religion, sex, gender, gender identity or expression, sexual orientation, national origin, ancestry, citizenship status, age, marital status, pregnancy, disability, or any other status protected by law. Reasonable accommodations available upon request during application/interview process. Seniority level
Mid-Senior level Employment type
Full-time Job function
Research and Development
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FIG Therapeutics, Inc.
is a preclinical biotech company developing the Symphony platform, a proprietary intratumorally-delivered multimodal gene immunotherapy. The role is a lab-forward Senior Scientist position based in Valhalla, NY (onsite, 5 days/week with occasional weekends). Report directly to the founder and CEO. Exceptional candidates may advance toward co-founder if aligned with the vision. Role summary
We are hiring a hands-on Senior Scientist to lead and execute the majority of pre-IND in vitro and in vivo work, designing, developing, running, qualifying, documenting, and presenting assays and preclinical studies that support IND filing and early CRO/GLP programs. Must-have qualifications
Must have been performed within the last 18 months (non-negotiable): Hands-on generation of CD34⁺ humanized mice and direct experience implanting/maintaining prostate PDX tumors Intratumoral injection and in vivo transfection optimization of PDX tumors Surgical tumor resection/necropsy with downstream tissue processing (IHC/IF and flow) Rational design of lipid nanoparticles for plasmid DNA delivery Viral vector (adenovirus and HSV), RNA, and polycistronic DNA plasmid design Cell culture and transfection/transduction of primary tumor cells, T cells, and cancer cell lines Development of cancer and immune cell co-culture assays Establishment of 3D organoid models of solid tumor TME Assay development for multicolor flow cytometry panels, ELISA, Luminex, ELISPOT, RT-qPCR, and digital PCR (dPCR) Ability to independently design experiments, troubleshoot complex failures, and author SOPs and study reports used to inform CRO/IND decisions Experience coordinating with CROs on GLP-style biodistribution/toxicity/TK studies and contributing to study plans Previous track record of IND support (authoring preclinical sections) and interactions with regulatory consultants Key responsibilities
Design, optimize, and run in-vitro potency & functional assays for multi-domain immune effectors Develop and validate quantitative assays: RT-qPCR, digital PCR (dPCR), ELISA, Luminex multiplex cytokine panels, ELISPOT, Western blot Build, optimize and analyze multicolor flow cytometry panels and perform data analysis (FlowJo/Cytobank) Run in-vitro immune function assays: PBMC cytotoxicity, NK/ADCC, DC activation, antigen-presentation readouts Establish and run tumor microenvironment (TME) models: 2D, 3D spheroids/organoids, tumor:immune co-cultures; provide assay qualification Lead in vivo programs: generation and management of CD34⁺ humanized mice, engraftment of patient-derived prostate PDX, tumor implantation, intratumoral dosing, surgical resection, necropsy, tissue processing for flow/IHC/IF and molecular readouts Design and execute GLP-style biodistribution, PK/PD, and toxicology study plans with CROs; write and review study protocols and reports for IND packages Author SOPs, experimental design docs, technical reports, and contribute to IND-enabling documentation Maintain data integrity, sample tracking, reagent QC; assist with reagent sourcing and basic CMC input Mentor and coordinate work with junior scientists/technicians and external CRO teams Role details
Salary Range: $50,000-$70,000/year + Equity (salary may increase with fundraising). Competitive benefits: health, dental, and vision. Application instructions & required verification materials
All of the following are required to be considered for the role. Email Cover Letter and CV to ariel@figtherapeutics.com. Do not use AI for the cover letter, as it would disqualify the application. Curriculum vitae (with dates and affiliations). Cover letter demonstrating understanding of the responsibilities as the first non-founder scientist hire in a small biotech, explicitly mapping how you meet each Must-Have item with dates (month/year) and employer/lab. Three professional references (name, title, phone, e-mail) to verify required experiences; include these references at the end of the CV. Permission to perform background check and employment verification. Willingness to sign a declaration that information provided is true and accurate. Applications not including the above materials will be rejected. Compliance & policy
Strict verification and disqualification policy: must have performed each Must-Have activity within the past 18 months and provide documentary evidence and references. Offers contingent on verification of employment, education, references, and background checks. State compliance and notices for criminal-history information where applicable. New York Clean Slate Act considerations apply as required. Equal Employment Opportunity & Workplace Policy: FIG Therapeutics is an equal opportunity employer. Decisions made without regard to race, color, religion, sex, gender, gender identity or expression, sexual orientation, national origin, ancestry, citizenship status, age, marital status, pregnancy, disability, or any other status protected by law. Reasonable accommodations available upon request during application/interview process. Seniority level
Mid-Senior level Employment type
Full-time Job function
Research and Development
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