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Dovetail Therapeutics

Senior/Principal Scientist, Protein Engineering

Dovetail Therapeutics, Seattle, Washington, us, 98127

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Dovetail Therapeutics is seeking a talented and motivated Senior/Principal Scientist to join our growing and dynamic team. If you are passionate about developing new technologies and contributing to the next generation of biotherapeutics in a collaborative and fast-paced environment where your contributions will make a real difference, this role is for you.

Key Duties and Responsibilities

Lead and contribute to discovery and optimization efforts for antibody candidates

Work with internal cross-functional teams and CROs to design and advance novel biotherapeutics

Develop and implement innovative strategies and methodologies to accelerate antibody discovery and engineering workflows

Analyze and effectively communicate ideas and findings to internal stakeholders

Knowledge and Skills

Expertise in antibody and protein science, molecular biology, and biotherapeutic discovery

Hands‑on experience in therapeutic protein and antibody engineering, particularly with optimization of molecular properties, affinity maturation, and/or antibody humanization

Proven ability in applying state‑of‑the‑art antibody engineering approaches and computational tools to shape design strategy and optimize workflows

Skilled in sequence analysis and structural modeling for protein design

Ability to synthesize functional and biophysical data and integrate high‑throughput datasets to guide selection and engineering strategies

Stay current on emerging trends in protein design and introduce innovative techniques to expand team capabilities

Qualifications

Ph.D. degree in structural biology, molecular biology, biochemistry or a related field

5+ years of experience in antibody discovery and protein engineering in an academic or industry setting; 2+ years of industry experience strongly preferred

Excellent organizational and communication skills with attention to detail

Ability to work in a fast‑paced, interdisciplinary environment

About Dovetail Therapeutics Dovetail Therapeutics is bringing life‑changing therapies to patients through its novel, next‑generation technologies. We are located at 1616 Eastlake Ave East in the vibrant South Lake Union area of Seattle. We foster a culture of collaboration and innovation in which every employee plays a critical role in shaping our success. Dovetail offers a competitive total compensation and benefits package. Benefits include medical, dental and vision coverage, paid parking or transit, a 401(k) plan, and paid time off, among other components.

Seniority level Mid‑Senior level

Employment type Full‑time

Job function Research, Analyst, and Information Technology

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