BioSpace
Senior Medical Director – Maze Therapeutics
Maze Therapeutics is seeking a Senior Medical Director to lead the clinical development strategy for our APOL1 program, an innovative approach targeting a key genetic driver of chronic kidney disease. In this highly visible leadership role, you will design and oversee early‑stage trials, guide cross‑functional teams, and ensure alignment with Maze’s mission to deliver transformative medicines.
You’ll engage with scientific thought leaders, patient advocacy groups, and global stakeholders to shape development plans and accelerate progress. This is an opportunity to combine your medical expertise with strategic vision to make a lasting impact on patients living with kidney disease.
In addition to the APOL1 program, Maze Therapeutics has an exciting pipeline focused on renal, cardiac, and metabolic diseases, including a second precision medicine for kidney disease following closely behind APOL1. This role offers the opportunity to play a fundamental part in advancing medical breakthroughs that have the potential to transform many lives.
This position reports to the Head of Clinical Development.
Key Impact
Lead the design, execution, and analysis of clinical trials for the APOL1 program and other early‑stage clinical assets at Maze.
Author and review clinical‑regulatory documents, including protocols and amendments, informed consents, study reports, and SAPs.
Prepare and deliver scientific presentations and other communication materials for internal and external stakeholders, including investigators and other Maze collaborators.
Engage with scientific thought leaders and patient advocacy groups to gain insights that inform clinical development plans and build awareness and enthusiasm for the Maze pipeline assets.
Partner with Clinical Development Operations to identify and select study investigators and sites, building strong professional relationships with study investigators.
Partner with Clinical Development Operations to identify, select, and oversee vendors and CROs to support program needs.
Develop and integrate timelines and budgets for clinical activities with overall company timelines and goals, in close coordination with project management, CMC, nonclinical development, regulatory affairs, and other stakeholders.
Leadership Competencies
Communication and Influence
Role models clear communication and open two‑way conversations.
Reinforces an environment where people feel heard and their opinions are valued.
Inspires followership despite differing initial opinions.
Teamwork and Collaboration
Champions collaboration and connection across Maze.
Establishes team norms and expectations.
Seeks opportunities to spotlight team and individual contributions in public forums.
Execution and Results
Develops recommendations to seize on opportunities and mitigate obstacles that could impact long‑term success.
Coaches others on resource management and work distribution/delegation.Aligns work to Maze’s strategy, mission, and vision.
Develop Others and Self
Develops staff capabilities to handle delegation of responsibilities.
Encourages staff to develop and execute personal stretch goals.
Identifies and recommends ways to increase inclusive leadership.
What We’re Looking For
MD with 6+ years of drug development industry experience.
Board eligibility/certification and clinical experience in internal medicine and/or pediatrics. Additional clinical or research experience in nephrology or cardiometabolic diseases is preferred.
Experience as a clinical study medical monitor.
Experience with the preparation and submission of scientific publications, study protocols, Investigator Brochures, and other clinical‑regulatory documents.
Experience in the planning and oversight of early‑stage and/or registration‑enabling clinical development programs including CRO and site selection and relationship building with investigators/site study staff, patient advocacy groups, and other third parties.
Demonstrated knowledge and experience in the design and conduct of clinical trials and clinical data analysis and interpretation, particularly Phase 2 trials.
Experience leading a cross‑functional study team.
Committed to nurturing relationships with investigators, site study staff, patient advocacy groups, and other third parties to support the clinical programs and broader Maze objectives.
Exceptional organizational, analytical, and communication skills, enabling you to translate corporate objectives into actionable plans that consistently deliver high‑quality data on time and within budget.
A positive and enthusiastic disposition, adaptability to changing environments, and unwavering personal and ethical standards in pursuit of corporate goals.
Willingness to travel domestically and internationally (up to 20%) for vendor visits, industry conferences, regulatory meetings, advisory boards, and other essential gatherings.
About Maze Therapeutics Maze Therapeutics is a clinical‑stage biopharmaceutical company harnessing the power of human genetics to develop novel, small‑molecule precision medicines for patients living with renal, cardiovascular, and related metabolic diseases, including obesity. The company’s pipeline uses its Compass platform to identify and characterize genetic variants in disease and link those variants to biological pathways that drive disease in specific patient groups through a process it calls variant functionalization. The company’s pipeline is led by two wholly owned lead programs, MZE829 and MZE782, each of which represents a novel precision‑medicine–based approach for chronic kidney disease. Maze is based in South San Francisco.
Location & Compensation Location: South San Francisco, CA.
Expected annual salary range: $338,000 – $412,000. This position is also eligible for an annual performance bonus.
Maze offers a robust benefits package to eligible employees, including competitive medical, dental, and vision insurance, mental health offerings, equity incentive plan, 401(k) program with employer match, and a generous holiday and PTO policy.
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You’ll engage with scientific thought leaders, patient advocacy groups, and global stakeholders to shape development plans and accelerate progress. This is an opportunity to combine your medical expertise with strategic vision to make a lasting impact on patients living with kidney disease.
In addition to the APOL1 program, Maze Therapeutics has an exciting pipeline focused on renal, cardiac, and metabolic diseases, including a second precision medicine for kidney disease following closely behind APOL1. This role offers the opportunity to play a fundamental part in advancing medical breakthroughs that have the potential to transform many lives.
This position reports to the Head of Clinical Development.
Key Impact
Lead the design, execution, and analysis of clinical trials for the APOL1 program and other early‑stage clinical assets at Maze.
Author and review clinical‑regulatory documents, including protocols and amendments, informed consents, study reports, and SAPs.
Prepare and deliver scientific presentations and other communication materials for internal and external stakeholders, including investigators and other Maze collaborators.
Engage with scientific thought leaders and patient advocacy groups to gain insights that inform clinical development plans and build awareness and enthusiasm for the Maze pipeline assets.
Partner with Clinical Development Operations to identify and select study investigators and sites, building strong professional relationships with study investigators.
Partner with Clinical Development Operations to identify, select, and oversee vendors and CROs to support program needs.
Develop and integrate timelines and budgets for clinical activities with overall company timelines and goals, in close coordination with project management, CMC, nonclinical development, regulatory affairs, and other stakeholders.
Leadership Competencies
Communication and Influence
Role models clear communication and open two‑way conversations.
Reinforces an environment where people feel heard and their opinions are valued.
Inspires followership despite differing initial opinions.
Teamwork and Collaboration
Champions collaboration and connection across Maze.
Establishes team norms and expectations.
Seeks opportunities to spotlight team and individual contributions in public forums.
Execution and Results
Develops recommendations to seize on opportunities and mitigate obstacles that could impact long‑term success.
Coaches others on resource management and work distribution/delegation.Aligns work to Maze’s strategy, mission, and vision.
Develop Others and Self
Develops staff capabilities to handle delegation of responsibilities.
Encourages staff to develop and execute personal stretch goals.
Identifies and recommends ways to increase inclusive leadership.
What We’re Looking For
MD with 6+ years of drug development industry experience.
Board eligibility/certification and clinical experience in internal medicine and/or pediatrics. Additional clinical or research experience in nephrology or cardiometabolic diseases is preferred.
Experience as a clinical study medical monitor.
Experience with the preparation and submission of scientific publications, study protocols, Investigator Brochures, and other clinical‑regulatory documents.
Experience in the planning and oversight of early‑stage and/or registration‑enabling clinical development programs including CRO and site selection and relationship building with investigators/site study staff, patient advocacy groups, and other third parties.
Demonstrated knowledge and experience in the design and conduct of clinical trials and clinical data analysis and interpretation, particularly Phase 2 trials.
Experience leading a cross‑functional study team.
Committed to nurturing relationships with investigators, site study staff, patient advocacy groups, and other third parties to support the clinical programs and broader Maze objectives.
Exceptional organizational, analytical, and communication skills, enabling you to translate corporate objectives into actionable plans that consistently deliver high‑quality data on time and within budget.
A positive and enthusiastic disposition, adaptability to changing environments, and unwavering personal and ethical standards in pursuit of corporate goals.
Willingness to travel domestically and internationally (up to 20%) for vendor visits, industry conferences, regulatory meetings, advisory boards, and other essential gatherings.
About Maze Therapeutics Maze Therapeutics is a clinical‑stage biopharmaceutical company harnessing the power of human genetics to develop novel, small‑molecule precision medicines for patients living with renal, cardiovascular, and related metabolic diseases, including obesity. The company’s pipeline uses its Compass platform to identify and characterize genetic variants in disease and link those variants to biological pathways that drive disease in specific patient groups through a process it calls variant functionalization. The company’s pipeline is led by two wholly owned lead programs, MZE829 and MZE782, each of which represents a novel precision‑medicine–based approach for chronic kidney disease. Maze is based in South San Francisco.
Location & Compensation Location: South San Francisco, CA.
Expected annual salary range: $338,000 – $412,000. This position is also eligible for an annual performance bonus.
Maze offers a robust benefits package to eligible employees, including competitive medical, dental, and vision insurance, mental health offerings, equity incentive plan, 401(k) program with employer match, and a generous holiday and PTO policy.
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