BioSpace
Sr. Principal Process Scientist - TS/MS Lab - Lebanon API Manufacturing
BioSpace, Lebanon, Indiana, United States, 46052
Job Summary
Eli Lilly and Company is seeking a highly motivated and skilled TS/MS Lab Sr. Principal Process Scientist to join our dynamic team. This role focuses on the development, optimization, and scale‑up of peptide synthesis and/or purification processes. Additionally, the Sr. Principal Process Scientist will be critical in advancing our peptide‑based therapeutic pipeline through commercialization, ensuring robust, efficient, and scalable manufacturing processes. Job Responsibilities
Lead and execute laboratory‑based research and development activities for the synthesis and/or purification of complex peptides, including solid‑phase peptide synthesis (SPPS) and solution‑phase peptide synthesis (LPPS). Design and perform experiments for process optimization, including reaction conditions, reagent selection, purification strategies (e.g., HPLC, preparative chromatography), and yield improvement. Troubleshoot and resolve technical challenges related to peptide synthesis and/or purification, applying a deep understanding of organic chemistry and peptide chemistry principles. Collaborate cross‑functionally with medicinal chemists, analytical chemists, process engineers, and manufacturing teams to ensure seamless technology transfer and scale‑up of peptide processes. Document experimental procedures, results, and conclusions thoroughly in laboratory notebooks and technical reports. Present findings and recommendations to project teams and senior management. Stay abreast of the latest scientific advancements in peptide chemistry, synthesis technologies, and purification techniques. Contribute to the development of intellectual property and patent applications. Adhere to all safety regulations and good laboratory practices (GLP). Minimum Requirements
Ph.D. in Organic Chemistry, Medicinal Chemistry, Chemical Engineering, or a related scientific discipline with a strong emphasis on peptide synthesis and purification. Minimum of 3 years of relevant experience in peptide process development within a pharmaceutical or biotechnology setting (post‑doctoral experience will be considered). Demonstrated expertise in both solid‑phase and solution‑phase peptide synthesis techniques. Proficiency in various preparative chromatography techniques, particularly HPLC and MPLC for peptide purification. Strong understanding of analytical techniques used for peptide characterization (LC‑MS, NMR, UV‑Vis, AAA, etc.). Additional Preferences
Experience with process scale‑up and technology transfer to manufacturing is highly desirable. Excellent problem‑solving skills and a strong ability to work independently and as part of a team. Outstanding written and verbal communication skills, with the ability to present complex scientific information clearly and concisely. Familiarity with cGMP principles and quality systems is a plus. EEO Statement
Lilly is proud to be an EEO employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status. Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form at
https://careers.lilly.com/us/en/workplace-accommodation
for further assistance. Compensation for this position ranges from $66,000 to $171,600 annually, depending on experience and qualifications. Eligible employees may also receive a company bonus and participate in our comprehensive benefits program, including 401(k), health, dental, vision, and other benefits.
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Eli Lilly and Company is seeking a highly motivated and skilled TS/MS Lab Sr. Principal Process Scientist to join our dynamic team. This role focuses on the development, optimization, and scale‑up of peptide synthesis and/or purification processes. Additionally, the Sr. Principal Process Scientist will be critical in advancing our peptide‑based therapeutic pipeline through commercialization, ensuring robust, efficient, and scalable manufacturing processes. Job Responsibilities
Lead and execute laboratory‑based research and development activities for the synthesis and/or purification of complex peptides, including solid‑phase peptide synthesis (SPPS) and solution‑phase peptide synthesis (LPPS). Design and perform experiments for process optimization, including reaction conditions, reagent selection, purification strategies (e.g., HPLC, preparative chromatography), and yield improvement. Troubleshoot and resolve technical challenges related to peptide synthesis and/or purification, applying a deep understanding of organic chemistry and peptide chemistry principles. Collaborate cross‑functionally with medicinal chemists, analytical chemists, process engineers, and manufacturing teams to ensure seamless technology transfer and scale‑up of peptide processes. Document experimental procedures, results, and conclusions thoroughly in laboratory notebooks and technical reports. Present findings and recommendations to project teams and senior management. Stay abreast of the latest scientific advancements in peptide chemistry, synthesis technologies, and purification techniques. Contribute to the development of intellectual property and patent applications. Adhere to all safety regulations and good laboratory practices (GLP). Minimum Requirements
Ph.D. in Organic Chemistry, Medicinal Chemistry, Chemical Engineering, or a related scientific discipline with a strong emphasis on peptide synthesis and purification. Minimum of 3 years of relevant experience in peptide process development within a pharmaceutical or biotechnology setting (post‑doctoral experience will be considered). Demonstrated expertise in both solid‑phase and solution‑phase peptide synthesis techniques. Proficiency in various preparative chromatography techniques, particularly HPLC and MPLC for peptide purification. Strong understanding of analytical techniques used for peptide characterization (LC‑MS, NMR, UV‑Vis, AAA, etc.). Additional Preferences
Experience with process scale‑up and technology transfer to manufacturing is highly desirable. Excellent problem‑solving skills and a strong ability to work independently and as part of a team. Outstanding written and verbal communication skills, with the ability to present complex scientific information clearly and concisely. Familiarity with cGMP principles and quality systems is a plus. EEO Statement
Lilly is proud to be an EEO employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status. Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form at
https://careers.lilly.com/us/en/workplace-accommodation
for further assistance. Compensation for this position ranges from $66,000 to $171,600 annually, depending on experience and qualifications. Eligible employees may also receive a company bonus and participate in our comprehensive benefits program, including 401(k), health, dental, vision, and other benefits.
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